Juncusol

CAS# 62023-90-9

Juncusol

Catalog No. BCN2926----Order now to get a substantial discount!

Product Name & Size Price Stock
Juncusol: 5mg $322 In Stock
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Quality Control of Juncusol

Number of papers citing our products

Chemical structure

Juncusol

3D structure

Chemical Properties of Juncusol

Cas No. 62023-90-9 SDF Download SDF
PubChem ID 72740 Appearance Powder
Formula C18H18O2 M.Wt 266.3
Type of Compound Phenols Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 5-ethenyl-1,6-dimethyl-9,10-dihydrophenanthrene-2,7-diol
SMILES CC1=C(C=CC2=C1CCC3=CC(=C(C(=C32)C=C)C)O)O
Standard InChIKey XNVMKPYDOHZJLR-UHFFFAOYSA-N
Standard InChI InChI=1S/C18H18O2/c1-4-13-10(2)17(20)9-12-5-6-14-11(3)16(19)8-7-15(14)18(12)13/h4,7-9,19-20H,1,5-6H2,2-3H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Juncusol

The stem of Juncus effusus L.

Biological Activity of Juncusol

Description1. Juncusol shows significant activity against MRSA strains. 2. Juncusol can induce caspase-3-mediated cytotoxicity in HT22 cells. 3. Juncusol shows anxiolytic and sedative activities, it shows anxiolytic activity at dosages of 10 mg/kg.
TargetsCaspase | Antifection

Juncusol Dilution Calculator

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Juncusol Molarity Calculator

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Preparing Stock Solutions of Juncusol

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.7552 mL 18.7758 mL 37.5516 mL 75.1033 mL 93.8791 mL
5 mM 0.751 mL 3.7552 mL 7.5103 mL 15.0207 mL 18.7758 mL
10 mM 0.3755 mL 1.8776 mL 3.7552 mL 7.5103 mL 9.3879 mL
50 mM 0.0751 mL 0.3755 mL 0.751 mL 1.5021 mL 1.8776 mL
100 mM 0.0376 mL 0.1878 mL 0.3755 mL 0.751 mL 0.9388 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Juncusol

Phenanthrenes from Juncus inflexus with Antimicrobial Activity against Methicillin-Resistant Staphylococcus aureus.[Pubmed:27808510]

J Nat Prod. 2016 Nov 23;79(11):2814-2823.

The present study has focused on an investigation of the antibacterial effects of Juncus inflexus and the isolation and identification of its active compounds. Eleven phenanthrenes were isolated from a methanolic extract of the roots. Four compounds (jinflexins A-D, 1-4) are new natural products, while seven phenanthrenes [juncuenins A (5), B (6), and D (8), Juncusol (7), dehydrojuncuenins A (9) and B (11), and dehydroJuncusol (10)] were isolated for the first time from the plant. Jinflexin D (4) is a dimer with an unprecedented heptacyclic ring system. The absolute configurations of the new compounds were determined by TDDFT-ECD calculations, and their enantiomeric purity was checked by chiral HPLC analysis. Extracts of different polarity (n-hexane, dichloromethane, and ethyl acetate) were evaluated for their antimicrobial effects against methicillin-resistant Staphylococcus aureus, extended-spectrum beta-lactamase (ESBL)-producing Citrobacter freundii, Escherichia coli, Enterobacter cloacae, Klebsiella pneumoniae, multiresistant Acinetobacter baumannii, and Pseudomonas aeruginosa. The MIC values of the isolated compounds were determined by a microdilution method. Jinflexin B (2), Juncusol (7), juncuenin D (8), and dehydrojuncuenin B (11) showed significant activity (MIC value range 12.5-100 mug/mL) against MRSA strains.

Phenanthrenes from Juncus effusus with anxiolytic and sedative activities.[Pubmed:22017742]

Nat Prod Res. 2012;26(13):1234-9.

Eight phenanthrenes, 7-carboxy-2-hydroxy-1-methyl-5-vinyl-phenanthrene (1); 2,7-dihydroxy-1-methyl-5-aldehyde-9,10-dihydrophenanthrene (2); dehydroeffusol (3); dehydroJuncusol (4); 7-carboxy-2-hydroxy-1-methyl-5-vinyl-9,10-dihydrophenanthrene (5); 8-carboxy-2-hydroxy-1-methyl-5-vinyl-9,10-dihydrophenanthrene (6); effusol (7) and Juncusol (8), were isolated from the aerial part of Juncus effusus. Compounds 1 and 2 were identified as new constituents. Compounds 7 and 8 showed anxiolytic and sedative activities.

Chemical constituents isolated from Juncus effusus induce cytotoxicity in HT22 cells.[Pubmed:25794817]

J Nat Med. 2015 Jul;69(3):421-6.

Effususol A (1), a new 9,10-dihydrophenanthrene, has been isolated from the medullae of Juncus effusus along with ten known compounds, effusol (2), dehydroeffusol (3), Juncusol (4), dehydroJuncusol (5), juncuenin B (6), dehydrojuncuenin B (7), juncuenin D (8), luteolin (9), luteolin 5-methyl ether (10), and 4-hydroxy-2,3-dimethyl-2-nonen-4-olide (11). The structure of 1 was elucidated on the basis of spectroscopic data. 2, 4, 6, 7, and 8 have induced caspase-3-mediated cytotoxicity in HT22 cells.

Two new anxiolytic phenanthrenes found in the medullae of Juncus effusus.[Pubmed:25233602]

Nat Prod Commun. 2014 Aug;9(8):1177-8.

Six phenanthrenes, 2-methoxy-7-hydroxy-1-methyl-5-vinyl phenanthrene (1), juncusin (2), dehydroeffusol (3), Juncusol (4), effusol (5), and dehydroeffusal (6), were isolated from the medullae of Juncus effusus L. Compounds 1 and 2 were identified as being new structures, and both of them showed anxiolytic activity at dosages of 10 and 2.5 mg/kg, respectively.

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