JuncusolCAS# 62023-90-9 |
Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 62023-90-9 | SDF | Download SDF |
| PubChem ID | 72740 | Appearance | Powder |
| Formula | C18H18O2 | M.Wt | 266.3 |
| Type of Compound | Phenols | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 5-ethenyl-1,6-dimethyl-9,10-dihydrophenanthrene-2,7-diol | ||
| SMILES | CC1=C(C=CC2=C1CCC3=CC(=C(C(=C32)C=C)C)O)O | ||
| Standard InChIKey | XNVMKPYDOHZJLR-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C18H18O2/c1-4-13-10(2)17(20)9-12-5-6-14-11(3)16(19)8-7-15(14)18(12)13/h4,7-9,19-20H,1,5-6H2,2-3H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Juncusol shows significant activity against MRSA strains. 2. Juncusol can induce caspase-3-mediated cytotoxicity in HT22 cells. 3. Juncusol shows anxiolytic and sedative activities, it shows anxiolytic activity at dosages of 10 mg/kg. |
| Targets | Caspase | Antifection |
Juncusol Dilution Calculator
Juncusol Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.7552 mL | 18.7758 mL | 37.5516 mL | 75.1033 mL | 93.8791 mL |
| 5 mM | 0.751 mL | 3.7552 mL | 7.5103 mL | 15.0207 mL | 18.7758 mL |
| 10 mM | 0.3755 mL | 1.8776 mL | 3.7552 mL | 7.5103 mL | 9.3879 mL |
| 50 mM | 0.0751 mL | 0.3755 mL | 0.751 mL | 1.5021 mL | 1.8776 mL |
| 100 mM | 0.0376 mL | 0.1878 mL | 0.3755 mL | 0.751 mL | 0.9388 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- Cyclobenzaprine HCl
Catalog No.:BCC6496
CAS No.:6202-23-9
- Bulgarsenine
Catalog No.:BCN2065
CAS No.:62018-77-3
- Helichrysetin
Catalog No.:BCN4149
CAS No.:62014-87-3
- p-Menthane-1,2,8-triol
Catalog No.:BCN4148
CAS No.:62014-81-7
- Dirithromycin
Catalog No.:BCC4656
CAS No.:62013-04-1
- CCG-63808
Catalog No.:BCC1461
CAS No.:620113-73-7
- CCG-63802
Catalog No.:BCC1460
CAS No.:620112-78-9
- Senkyunolide A
Catalog No.:BCN6351
CAS No.:62006-39-7
- 4,4'-Methylenediphenol
Catalog No.:BCN2690
CAS No.:620-92-8
- Hyoscyamine sulfate hydrate
Catalog No.:BCN2846
CAS No.:620-61-1
- Tribenzylamine
Catalog No.:BCN1817
CAS No.:620-40-6
- 5-Methyl-2-furaldehyde
Catalog No.:BCN3801
CAS No.:620-02-0
- Ginsenoside F2
Catalog No.:BCN1245
CAS No.:62025-49-4
- Ginsenoside F3
Catalog No.:BCN1077
CAS No.:62025-50-7
- 4-(Dimethylamino)cinnamaldehyde
Catalog No.:BCN4968
CAS No.:6203-18-5
- Onitisin 2'-O-glucoside
Catalog No.:BCN4150
CAS No.:62043-53-2
- Hydroxycitric acid
Catalog No.:BCN2912
CAS No.:6205-14-7
- Nudiposide
Catalog No.:BCN7437
CAS No.:62058-46-2
- Heliotrine N-oxide
Catalog No.:BCN1983
CAS No.:6209-65-0
- 3-Nitro-L-tyrosine
Catalog No.:BCN2213
CAS No.:621-44-3
- Isovanillin
Catalog No.:BCN2502
CAS No.:621-59-0
- Scutebarbatine E
Catalog No.:BCN8396
CAS No.:910099-77-3
- Benzyl carbamate
Catalog No.:BCC8871
CAS No.:621-84-1
- Rauwolscine hydrochloride
Catalog No.:BCC6834
CAS No.:6211-32-1
Phenanthrenes from Juncus inflexus with Antimicrobial Activity against Methicillin-Resistant Staphylococcus aureus.[Pubmed:27808510]
J Nat Prod. 2016 Nov 23;79(11):2814-2823.
The present study has focused on an investigation of the antibacterial effects of Juncus inflexus and the isolation and identification of its active compounds. Eleven phenanthrenes were isolated from a methanolic extract of the roots. Four compounds (jinflexins A-D, 1-4) are new natural products, while seven phenanthrenes [juncuenins A (5), B (6), and D (8), Juncusol (7), dehydrojuncuenins A (9) and B (11), and dehydroJuncusol (10)] were isolated for the first time from the plant. Jinflexin D (4) is a dimer with an unprecedented heptacyclic ring system. The absolute configurations of the new compounds were determined by TDDFT-ECD calculations, and their enantiomeric purity was checked by chiral HPLC analysis. Extracts of different polarity (n-hexane, dichloromethane, and ethyl acetate) were evaluated for their antimicrobial effects against methicillin-resistant Staphylococcus aureus, extended-spectrum beta-lactamase (ESBL)-producing Citrobacter freundii, Escherichia coli, Enterobacter cloacae, Klebsiella pneumoniae, multiresistant Acinetobacter baumannii, and Pseudomonas aeruginosa. The MIC values of the isolated compounds were determined by a microdilution method. Jinflexin B (2), Juncusol (7), juncuenin D (8), and dehydrojuncuenin B (11) showed significant activity (MIC value range 12.5-100 mug/mL) against MRSA strains.
Phenanthrenes from Juncus effusus with anxiolytic and sedative activities.[Pubmed:22017742]
Nat Prod Res. 2012;26(13):1234-9.
Eight phenanthrenes, 7-carboxy-2-hydroxy-1-methyl-5-vinyl-phenanthrene (1); 2,7-dihydroxy-1-methyl-5-aldehyde-9,10-dihydrophenanthrene (2); dehydroeffusol (3); dehydroJuncusol (4); 7-carboxy-2-hydroxy-1-methyl-5-vinyl-9,10-dihydrophenanthrene (5); 8-carboxy-2-hydroxy-1-methyl-5-vinyl-9,10-dihydrophenanthrene (6); effusol (7) and Juncusol (8), were isolated from the aerial part of Juncus effusus. Compounds 1 and 2 were identified as new constituents. Compounds 7 and 8 showed anxiolytic and sedative activities.
Chemical constituents isolated from Juncus effusus induce cytotoxicity in HT22 cells.[Pubmed:25794817]
J Nat Med. 2015 Jul;69(3):421-6.
Effususol A (1), a new 9,10-dihydrophenanthrene, has been isolated from the medullae of Juncus effusus along with ten known compounds, effusol (2), dehydroeffusol (3), Juncusol (4), dehydroJuncusol (5), juncuenin B (6), dehydrojuncuenin B (7), juncuenin D (8), luteolin (9), luteolin 5-methyl ether (10), and 4-hydroxy-2,3-dimethyl-2-nonen-4-olide (11). The structure of 1 was elucidated on the basis of spectroscopic data. 2, 4, 6, 7, and 8 have induced caspase-3-mediated cytotoxicity in HT22 cells.
Two new anxiolytic phenanthrenes found in the medullae of Juncus effusus.[Pubmed:25233602]
Nat Prod Commun. 2014 Aug;9(8):1177-8.
Six phenanthrenes, 2-methoxy-7-hydroxy-1-methyl-5-vinyl phenanthrene (1), juncusin (2), dehydroeffusol (3), Juncusol (4), effusol (5), and dehydroeffusal (6), were isolated from the medullae of Juncus effusus L. Compounds 1 and 2 were identified as being new structures, and both of them showed anxiolytic activity at dosages of 10 and 2.5 mg/kg, respectively.
