NudiposideCAS# 62058-46-2 |
- Lyoniside
Catalog No.:BCN5277
CAS No.:34425-25-7
Quality Control & MSDS
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| Cas No. | 62058-46-2 | SDF | Download SDF |
| PubChem ID | 14521040 | Appearance | Powder |
| Formula | C27H36O12 | M.Wt | 552.57 |
| Type of Compound | Lignans | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (2R,3R,4S,5R)-2-[[(1R,2S,3S)-7-hydroxy-1-(4-hydroxy-3,5-dimethoxyphenyl)-3-(hydroxymethyl)-6,8-dimethoxy-1,2,3,4-tetrahydronaphthalen-2-yl]methoxy]oxane-3,4,5-triol | ||
| SMILES | COC1=CC(=CC(=C1O)OC)C2C(C(CC3=CC(=C(C(=C23)OC)O)OC)CO)COC4C(C(C(CO4)O)O)O | ||
| Standard InChIKey | GWDZRGQRNHELQM-NHJKQUFYSA-N | ||
| Standard InChI | InChI=1S/C27H36O12/c1-34-17-7-13(8-18(35-2)23(17)31)20-15(10-38-27-25(33)22(30)16(29)11-39-27)14(9-28)5-12-6-19(36-3)24(32)26(37-4)21(12)20/h6-8,14-16,20,22,25,27-33H,5,9-11H2,1-4H3/t14-,15-,16-,20+,22+,25-,27-/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Nudiposide has significant neuroprotective activities against glutamate-injured neurotoxicity in HT22 cells. 2. Nudiposide exhibits protective effect against sepsis in a mouse model and can decrease the plasma levels of TNF-α, IL-10 and ALT activity. |
| Targets | TNF-α | IL Receptor |
Nudiposide Dilution Calculator
Nudiposide Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.8097 mL | 9.0486 mL | 18.0973 mL | 36.1945 mL | 45.2431 mL |
| 5 mM | 0.3619 mL | 1.8097 mL | 3.6195 mL | 7.2389 mL | 9.0486 mL |
| 10 mM | 0.181 mL | 0.9049 mL | 1.8097 mL | 3.6195 mL | 4.5243 mL |
| 50 mM | 0.0362 mL | 0.181 mL | 0.3619 mL | 0.7239 mL | 0.9049 mL |
| 100 mM | 0.0181 mL | 0.0905 mL | 0.181 mL | 0.3619 mL | 0.4524 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Protective constituents against sepsis in mice from the root barks of Ulmus davidiana var. japonica.[Pubmed:21975805]
Arch Pharm Res. 2011 Sep;34(9):1443-50.
In the course of isolating preventive agents against sepsis based on the in vivo assay model, eleven known compounds, (-)-catechin (1), catechin-7-O-beta-apiofuranoside (2), catechin-7-O-alpha-Lrhamnopyranoside (3), catechin-3-O-alpha-L-rhamnopyranoside (4), catechin-7-O-beta-D-glucopyranoside (5), butyl (+)-5'-methoxyisolariciresinol-9'-O-beta-D-xylopyranoside (6), lyoniside (7), Nudiposide (8), alpha-nigerose (9), butyl alpha-D-fructofuranoside (10), and procyanidin B(3) (11) were isolated from the root barks of Ulmus davidiana var. japonica. Compounds 2, 6, and 8 significantly protected against sepsis in a mouse model with survival rates of mice exposed to 10 mg/kg of LPS/D-GalN ranged from 80%-100%. Among them, 8 exhibited the most potent protective effect and decreased the plasma levels of TNF-alpha, IL-10 and ALT activity.
Neuroprotective compounds of Tilia amurensis.[Pubmed:26664019]
Pharmacogn Mag. 2015 Oct;11(Suppl 2):S303-7.
BACKGROUND: Tilia amurensis (Tiliacese) has been used for anti-tumor and anti-inflammatory in Korea, China, and Japan. OBJECTIVE: In this study, we isolated five compounds from T. amurensis and determined whether protected neuronal cells against glutamate-induced oxidative stress in HT22 cells. MATERIALS AND METHODS: Compounds were isolated using chromatographic techniques including silica gel, Sephadex LH-20 open column and high performance liquid chromatography analysis, and evaluated neuroprotective effect in HT22 cells by 3-(4,5-dimethythiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay. RESULTS: beta-D-fructofuranosyl alpha-D-glucopyranoside (1), (-)-epicatechin (2), Nudiposide (3), lyoniside (4), and scopoletin (5) were isolated by bioactivity-guided fractionation from the ethyl acetate fraction of T. amurensis. Among them, (-)-epicatechin, Nudiposide, lyoniside, and scopoletin had significant neuroprotective activities against glutamate-injured neurotoxicity in HT22 cells. CONCLUSION: These results demonstrated that compound two, three, four, and five have a pronounced protective effect against glutamate-induced neurotoxicity in HT22 cells.
