7-Acetylintermedine N-oxide

CAS# 685132-59-6

7-Acetylintermedine N-oxide

Catalog No. BCN0353----Order now to get a substantial discount!

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Quality Control of 7-Acetylintermedine N-oxide

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Chemical structure

7-Acetylintermedine N-oxide

Chemical Properties of 7-Acetylintermedine N-oxide

Cas No. 685132-59-6 SDF Download SDF
PubChem ID N/A Appearance White powder
Formula C17H27NO7 M.Wt 357.4
Type of Compound Nitrogen-containing Compounds Storage Desiccate at -20°C
Synonyms Intermedine 1-acetate N-oxide
Solubility Soluble in methanol and water
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 7-Acetylintermedine N-oxide

1 Symphytum sp.

7-Acetylintermedine N-oxide Dilution Calculator

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7-Acetylintermedine N-oxide Molarity Calculator

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Preparing Stock Solutions of 7-Acetylintermedine N-oxide

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.798 mL 13.9899 mL 27.9799 mL 55.9597 mL 69.9496 mL
5 mM 0.5596 mL 2.798 mL 5.596 mL 11.1919 mL 13.9899 mL
10 mM 0.2798 mL 1.399 mL 2.798 mL 5.596 mL 6.995 mL
50 mM 0.056 mL 0.2798 mL 0.5596 mL 1.1192 mL 1.399 mL
100 mM 0.028 mL 0.1399 mL 0.2798 mL 0.5596 mL 0.6995 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 7-Acetylintermedine N-oxide

Analysis of pyrrolizidine alkaloids in Eupatorium fortunei Turcz. and their in vitro neurotoxicity.[Pubmed:33774095]

Food Chem Toxicol. 2021 May;151:112151.

This study was to analyze the pyrrolizidine alkaloids (PAs) in Eupatorium fortunei herbs and its derived finished products with a view to evaluating their effects on the proliferation and oligodendrogenesis of neural progenitor cells (NPCs). Using a LC-MS/MS method with 32 PAs reference standards, 8 PAs including intermedine, intermedine N-oxide, lycopsamine, lycopsamine N-oxide, retronecine, seneciphylline and senkirkine and 7-Acetylintermedine N-oxide were identified with intermedine N-oxide and lycopsamine N-oxide being most abundant. The total PA amounts were found to vary from 0.18 to 61.81 mug/g in 30 batches of herbs and from 0.86 to 36.96 mug/g in 4 commercial finished products, respectively. Risk assessments indicated that the short-term intake seemed unlikely lead to acute toxic effects but the chronic use warranted cautions. Using NPCs derived from mouse induced pluripotent stem cells as an in vitro testing model, intermedine, intermedine N-oxide and lycopsamine N-oxide appeared to decrease cell viability at 30 muM whereas intermedine N-oxide inhibited oligodendrogenesis of NPCs at 10 muM. The present results suggested that the PAs in the majority of E. fortunei herbs and the derived products not only resulted in their exposure far exceeding the acceptable intake limit (i. e. 1.0 mug PA per day for adults) in herbal medicinal products recommended by the European Medicines Agency but also induced neurotoxicity to NPCs in vitro.

Reduction of Pyrrolizidine Alkaloid Levels in Comfrey (Symphytum officinale) Hairy Roots by RNAi Silencing of Homospermidine Synthase.[Pubmed:31450245]

Planta Med. 2019 Oct;85(14-15):1177-1186.

Comfrey is a medicinal plant, extracts of which are traditionally used for the treatment of painful inflammatory muscle and joint problems, because the plant contains allantoin and rosmarinic acid. However, its medicinal use is limited because of its toxic pyrrolizidine alkaloid (PA) content. PAs encompass more than 400 different compounds that have been identified from various plant lineages. To date, only the first pathway-specific enzyme, homospermidine synthase (HSS), has been characterized. HSS catalyzes the formation of homospermidine, which is exclusively incorporated into PAs. HSS has been recruited several times independently in various plant lineages during evolution by duplication of the gene encoding deoxyhypusine synthase (DHS), an enzyme of primary metabolism. Here, we describe the establishment of RNAi knockdown hairy root mutants of HSS in Symphytum officinale. A knockdown of HSS by 60 - 80% resulted in a significant reduction of homospermidine by ~ 86% and of the major PA components 7-Acetylintermedine N-oxide and 3-acetylmyoscorpine N-oxide by approximately 60%. The correlation of reduced transcript levels of HSS with reduced levels of homospermidine and PAs provides in planta support for HSS being the central enzyme in PA biosynthesis. Furthermore, the generation of PA-depleted hairy roots might be a cost-efficient way for reducing toxic by-products that limit the medicinal applicability of S. officinale extracts.

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