Home >> Research Area >>Others>>RAR/RXR>> Acitretin sodium

Acitretin sodium

CAS# 925701-88-8

Acitretin sodium

Catalog No. BCC4299----Order now to get a substantial discount!

Product Name & Size Price Stock
Acitretin sodium: 5mg $12 In Stock
Acitretin sodium: 10mg Please Inquire In Stock
Acitretin sodium: 20mg Please Inquire Please Inquire
Acitretin sodium: 50mg Please Inquire Please Inquire
Acitretin sodium: 100mg Please Inquire Please Inquire
Acitretin sodium: 200mg Please Inquire Please Inquire
Acitretin sodium: 500mg Please Inquire Please Inquire
Acitretin sodium: 1000mg Please Inquire Please Inquire
Related Products

Quality Control of Acitretin sodium

Number of papers citing our products

Chemical structure

Acitretin sodium

3D structure

Chemical Properties of Acitretin sodium

Cas No. 925701-88-8 SDF Download SDF
PubChem ID 87670907 Appearance Powder
Formula C21H25NaO3 M.Wt 348.41
Type of Compound N/A Storage Desiccate at -20°C
Synonyms Ro 10-1670 sodium
Solubility Soluble in DMSO
Chemical Name (2E,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid;sodium
SMILES CC1=CC(=C(C(=C1C=CC(=CC=CC(=CC(=O)O)C)C)C)C)OC.[Na]
Standard InChIKey QTGFSGVSWOBQLB-WMOHYEITSA-N
Standard InChI InChI=1S/C21H26O3.Na/c1-14(8-7-9-15(2)12-21(22)23)10-11-19-16(3)13-20(24-6)18(5)17(19)4;/h7-13H,1-6H3,(H,22,23);/b9-7+,11-10+,14-8+,15-12+;
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of Acitretin sodium

DescriptionAcitretin sodium(Ro 10-1670) is a second-generation, systemic retinoid that has been used in the treatment of psoriasis. Target: RAR/RXR Acitretin sodium is a second-generation, systemic retinoid that has been approved for the treatment of psoriasis since 1997. It can be considered one of the treatments of choice for pustular and erythrodermic psoriasis. However, the efficacy of acitretin sodium as a monotherapy for plaque psoriasis is less, although it is often used in combination therapy with other systemic psoriasis therapies, especially ultraviolet B or psoralen plus ultraviolet A phototherapy, to increase efficacy. Such combination treatments may potentially minimise toxicity by using lower doses of each of the two agent [1]. Thirty-nine male adult Wistar albino rats were divided into 3 groups as two experimental groups and one control group. The first group consisting 14 rats were applied orally standard dose (0.75 mg/kg/day) acitretin sodium and the second group consisting 16 rats were applied high dose (1.5 mg/kg/day) acitretin sodium. Acitretin sodium was given within dimetil sulphoxide (DMSO), which was diluted with saline solution as a ratio of 1/10, in order to increase its solubility. The control group consisting 9 rats were given only saline solution including DMSO for 8 weeks. After 8 weeks of the administration, half of the rats in the first and second groups and the entire control group were sacrificed under deep ether anaesthesia and bilateral orchiectomy was made. The remainingrats were compared with the control group using a similar method at the end of 8 weeks of wash-off period. The orchiectomy materials were histopathologically evaluated under the light microscope for spermatogenesis according to parameters including spermatogenetic activity, spermatogenetic organization, seminiferous tubular diameter, interstitial Leydig cells and fibroblasts. In our study it was concluded that the standard and high doses of acitretin sodium do not have any effect on the spermatogenesis of threats [2]. Clinical indications: Psoriasis FDA Approved Date: Toxicity: nausea; headache; itching; red or flaky skin; dry or red eyes; dry mouth; depression; hair loss

References:
[1]. Lee CS, et al. A review of acitretin, a systemic retinoid for the treatment of psoriasis. Expert Opin Pharmacother. 2005 Aug;6(10):1725-34. [2]. Seng?r B, et al. Effects of acitretin on spermatogenesis of rats. J Eur Acad Dermatol Venereol. 2006 Jul;20(6):689-92.

Acitretin sodium Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

Acitretin sodium Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of Acitretin sodium

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.8702 mL 14.3509 mL 28.7018 mL 57.4036 mL 71.7545 mL
5 mM 0.574 mL 2.8702 mL 5.7404 mL 11.4807 mL 14.3509 mL
10 mM 0.287 mL 1.4351 mL 2.8702 mL 5.7404 mL 7.1755 mL
50 mM 0.0574 mL 0.287 mL 0.574 mL 1.1481 mL 1.4351 mL
100 mM 0.0287 mL 0.1435 mL 0.287 mL 0.574 mL 0.7175 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University

Background on Acitretin sodium

Acitretin sodium is a second-generation, systemic retinoid that has been used in the treatment of psoriasis.

Featured Products
New Products
 

Description

Acitretin sodium(Ro 10-1670) is a second-generation, systemic retinoid that has been used in the treatment of psoriasis.

Keywords:

Acitretin sodium,925701-88-8,Ro 10-1670 sodium,Natural Products,RAR/RXR, buy Acitretin sodium , Acitretin sodium supplier , purchase Acitretin sodium , Acitretin sodium cost , Acitretin sodium manufacturer , order Acitretin sodium , high purity Acitretin sodium

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: