Acitretin sodiumCAS# 925701-88-8 |
Related Products
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
Cas No. | 925701-88-8 | SDF | Download SDF |
PubChem ID | 87670907 | Appearance | Powder |
Formula | C21H25NaO3 | M.Wt | 348.41 |
Type of Compound | N/A | Storage | Desiccate at -20°C |
Synonyms | Ro 10-1670 sodium | ||
Solubility | Soluble in DMSO | ||
Chemical Name | (2E,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid;sodium | ||
SMILES | CC1=CC(=C(C(=C1C=CC(=CC=CC(=CC(=O)O)C)C)C)C)OC.[Na] | ||
Standard InChIKey | QTGFSGVSWOBQLB-WMOHYEITSA-N | ||
Standard InChI | InChI=1S/C21H26O3.Na/c1-14(8-7-9-15(2)12-21(22)23)10-11-19-16(3)13-20(24-6)18(5)17(19)4;/h7-13H,1-6H3,(H,22,23);/b9-7+,11-10+,14-8+,15-12+; | ||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. |
Description | Acitretin sodium(Ro 10-1670) is a second-generation, systemic retinoid that has been used in the treatment of psoriasis.
Target: RAR/RXR
Acitretin sodium is a second-generation, systemic retinoid that has been approved for the treatment of psoriasis since 1997. It can be considered one of the treatments of choice for pustular and erythrodermic psoriasis. However, the efficacy of acitretin sodium as a monotherapy for plaque psoriasis is less, although it is often used in combination therapy with other systemic psoriasis therapies, especially ultraviolet B or psoralen plus ultraviolet A phototherapy, to increase efficacy. Such combination treatments may potentially minimise toxicity by using lower doses of each of the two agent [1].
Thirty-nine male adult Wistar albino rats were divided into 3 groups as two experimental groups and one control group. The first group consisting 14 rats were applied orally standard dose (0.75 mg/kg/day) acitretin sodium and the second group consisting 16 rats were applied high dose (1.5 mg/kg/day) acitretin sodium. Acitretin sodium was given within dimetil sulphoxide (DMSO), which was diluted with saline solution as a ratio of 1/10, in order to increase its solubility. The control group consisting 9 rats were given only saline solution including DMSO for 8 weeks. After 8 weeks of the administration, half of the rats in the first and second groups and the entire control group were sacrificed under deep ether anaesthesia and bilateral orchiectomy was made. The remainingrats were compared with the control group using a similar method at the end of 8 weeks of wash-off period. The orchiectomy materials were histopathologically evaluated under the light microscope for spermatogenesis according to parameters including spermatogenetic activity, spermatogenetic organization, seminiferous tubular diameter, interstitial Leydig cells and fibroblasts. In our study it was concluded that the standard and high doses of acitretin sodium do not have any effect on the spermatogenesis of threats [2].
Clinical indications: Psoriasis
FDA Approved Date:
Toxicity: nausea; headache; itching; red or flaky skin; dry or red eyes; dry mouth; depression; hair loss References: |
Acitretin sodium Dilution Calculator
Acitretin sodium Molarity Calculator
1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
1 mM | 2.8702 mL | 14.3509 mL | 28.7018 mL | 57.4036 mL | 71.7545 mL |
5 mM | 0.574 mL | 2.8702 mL | 5.7404 mL | 11.4807 mL | 14.3509 mL |
10 mM | 0.287 mL | 1.4351 mL | 2.8702 mL | 5.7404 mL | 7.1755 mL |
50 mM | 0.0574 mL | 0.287 mL | 0.574 mL | 1.1481 mL | 1.4351 mL |
100 mM | 0.0287 mL | 0.1435 mL | 0.287 mL | 0.574 mL | 0.7175 mL |
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. |
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
Acitretin sodium is a second-generation, systemic retinoid that has been used in the treatment of psoriasis.
Featured Products
- KU-60019
Catalog No.:BCC3699
CAS No.:925701-49-1
- 10-DEBC hydrochloride
Catalog No.:BCC7409
CAS No.:925681-41-0
- Jingzhaotoxin III
Catalog No.:BCC6327
CAS No.:925463-91-8
- Viscidulin I
Catalog No.:BCN4465
CAS No.:92519-95-4
- Viscidulin II
Catalog No.:BCN3187
CAS No.:92519-93-2
- Viscidulin III
Catalog No.:BCN4464
CAS No.:92519-91-0
- 21-Deoxyneridienone B
Catalog No.:BCN4463
CAS No.:924910-83-8
- Rupesin E
Catalog No.:BCN7009
CAS No.:924901-58-6
- 4,5-Epoxyartemisinic acid
Catalog No.:BCN4462
CAS No.:92466-31-4
- AZD-5597
Catalog No.:BCC6453
CAS No.:924641-59-8
- T 5601640
Catalog No.:BCC5617
CAS No.:924473-59-6
- AdipoRon
Catalog No.:BCC4756
CAS No.:924416-43-3
New Products
- 3-Isomangostin hydrate formate
Catalog No.:BCN4466
CAS No.:925705-36-8
- TG100713
Catalog No.:BCC4985
CAS No.:925705-73-3
- Secaubryenol
Catalog No.:BCN4467
CAS No.:925932-08-7
- Secaubrytriol
Catalog No.:BCN4468
CAS No.:925932-10-1
- Dayecrystal A
Catalog No.:BCN4859
CAS No.:926010-24-4
- AMTB hydrochloride
Catalog No.:BCC7834
CAS No.:926023-82-7
- Radotinib(IY-5511)
Catalog No.:BCC6398
CAS No.:926037-48-1
- O-Demethylforbexanthone
Catalog No.:BCN4469
CAS No.:92609-77-3
- Milnacipran
Catalog No.:BCC4194
CAS No.:92623-85-3
- BG45
Catalog No.:BCC6469
CAS No.:926259-99-6
- GGsTop
Catalog No.:BCC6187
CAS No.:926281-37-0
- Deltatsine
Catalog No.:BCN8106
CAS No.:92631-66-8
Acitretin sodium(Ro 10-1670) is a second-generation, systemic retinoid that has been used in the treatment of psoriasis.
Acitretin sodium,925701-88-8,Ro 10-1670 sodium,Natural Products,RAR/RXR, buy Acitretin sodium , Acitretin sodium supplier , purchase Acitretin sodium , Acitretin sodium cost , Acitretin sodium manufacturer , order Acitretin sodium , high purity Acitretin sodium