Viscidulin IICAS# 92519-93-2 |
2D Structure
Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
Cas No. | 92519-93-2 | SDF | Download SDF |
PubChem ID | 5322059 | Appearance | Yellow powder |
Formula | C17H14O7 | M.Wt | 330.3 |
Type of Compound | Flavonoids | Storage | Desiccate at -20°C |
Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
Chemical Name | 2-(2,6-dihydroxyphenyl)-5-hydroxy-7,8-dimethoxychromen-4-one | ||
SMILES | COC1=C(C2=C(C(=C1)O)C(=O)C=C(O2)C3=C(C=CC=C3O)O)OC | ||
Standard InChIKey | GWRFNPJGKCUUSJ-UHFFFAOYSA-N | ||
Standard InChI | InChI=1S/C17H14O7/c1-22-13-7-11(21)15-10(20)6-12(24-17(15)16(13)23-2)14-8(18)4-3-5-9(14)19/h3-7,18-19,21H,1-2H3 | ||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. |
Description | 1. Viscidulin II can significantly suppress P. acnes-induced IL-8 and IL-1β production in THP-1 cells, concomitant intradermal injection of viscidulin II with P. acnes can effectively attenuate P. acnes-induced ear swelling, and decrease the production of IL-6 and tumor necrosis factor-α in ear homogenates; suggests that it can be potential therapeutic agents against P. acnes-induced skin inflammation. |
Targets | IL Receptor |
Viscidulin II Dilution Calculator
Viscidulin II Molarity Calculator
1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
1 mM | 3.0276 mL | 15.1378 mL | 30.2755 mL | 60.551 mL | 75.6888 mL |
5 mM | 0.6055 mL | 3.0276 mL | 6.0551 mL | 12.1102 mL | 15.1378 mL |
10 mM | 0.3028 mL | 1.5138 mL | 3.0276 mL | 6.0551 mL | 7.5689 mL |
50 mM | 0.0606 mL | 0.3028 mL | 0.6055 mL | 1.211 mL | 1.5138 mL |
100 mM | 0.0303 mL | 0.1514 mL | 0.3028 mL | 0.6055 mL | 0.7569 mL |
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. |
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- Viscidulin III
Catalog No.:BCN4464
CAS No.:92519-91-0
- 21-Deoxyneridienone B
Catalog No.:BCN4463
CAS No.:924910-83-8
- Rupesin E
Catalog No.:BCN7009
CAS No.:924901-58-6
- 4,5-Epoxyartemisinic acid
Catalog No.:BCN4462
CAS No.:92466-31-4
- AZD-5597
Catalog No.:BCC6453
CAS No.:924641-59-8
- T 5601640
Catalog No.:BCC5617
CAS No.:924473-59-6
- AdipoRon
Catalog No.:BCC4756
CAS No.:924416-43-3
- HBX 41108
Catalog No.:BCC6137
CAS No.:924296-39-9
- DUBs-IN-2
Catalog No.:BCC5257
CAS No.:924296-19-5
- DUBs-IN-1
Catalog No.:BCC5256
CAS No.:924296-18-4
- DUBs-IN-3
Catalog No.:BCC5258
CAS No.:924296-17-3
- 3-Acetoxy-4-cadinen-8-one
Catalog No.:BCN4461
CAS No.:923950-05-4
- Viscidulin I
Catalog No.:BCN4465
CAS No.:92519-95-4
- Jingzhaotoxin III
Catalog No.:BCC6327
CAS No.:925463-91-8
- 10-DEBC hydrochloride
Catalog No.:BCC7409
CAS No.:925681-41-0
- KU-60019
Catalog No.:BCC3699
CAS No.:925701-49-1
- Acitretin sodium
Catalog No.:BCC4299
CAS No.:925701-88-8
- 3-Isomangostin hydrate formate
Catalog No.:BCN4466
CAS No.:925705-36-8
- TG100713
Catalog No.:BCC4985
CAS No.:925705-73-3
- Secaubryenol
Catalog No.:BCN4467
CAS No.:925932-08-7
- Secaubrytriol
Catalog No.:BCN4468
CAS No.:925932-10-1
- Dayecrystal A
Catalog No.:BCN4859
CAS No.:926010-24-4
- AMTB hydrochloride
Catalog No.:BCC7834
CAS No.:926023-82-7
- Radotinib(IY-5511)
Catalog No.:BCC6398
CAS No.:926037-48-1
Flavones Isolated from Scutellariae radix Suppress Propionibacterium Acnes-Induced Cytokine Production In Vitro and In Vivo.[Pubmed:26712724]
Molecules. 2015 Dec 24;21(1):E15.
Scutellariae radix, the root of Scutellaria baicalensis, has long been applied in traditional formulations and modern herbal medications. Propionibacterium acnes (P. acnes) in follicles can trigger inflammation and lead to the symptom of inflammatory acnes vulgaris. This study was aimed at evaluating the effect of Scutellariae radix extract and purified components isolated from it on inflammation induced by P. acnes in vitro and in vivo. The results showed the ethyl acetate (EA) soluble fraction from the partition of crude ethanolic extract from Scutellariae radix inhibited P. acnes-induced interleukin IL-8 and IL-1beta production in human monocytic THP-1 cells. Seven flavones were isolated from the EA fraction by repeated chromatographies, and identified as 5,7-dihydroxy-6-methoxyflavone (FL1, oroxylin), 5,7-dihydroxy-8-methoxyflavone (FL2, wogonin), 5-hydroxy-7,8-dimethoxyflavone (FL3, 7-O-methylwogonin), 5,6'-dihydroxy-6,7,8,2'-tetramethoxy flavone (FL4, skullcapflavone II), 5,7,4'-trihydroxy-8-methoxyflavone (FL5), 5,2',6'-trihydroxy-7,8-dimethoxyflavone (FL6, Viscidulin II), and 5,7,2',5'-tetrahydroxy-8,6'-dimethoxyflavone (FL7, ganhuangenin). They all significantly suppressed P. acnes-induced IL-8 and IL-1beta production in THP-1 cells, and FL2 exerted the strongest effect with half maximal inhibition (IC50) values of 8.7 and 4.9 muM, respectively. Concomitant intradermal injection of each of the seven flavones (20 mug) with P. acnes effectively attenuated P. acnes-induced ear swelling, and decreased the production of IL-6 and tumor necrosis factor-alpha in ear homogenates. Our results suggested that all the seven flavones can be potential therapeutic agents against P. acnes-induced skin inflammation.