DUBs-IN-3CAS# 924296-17-3 |
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Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 924296-17-3 | SDF | Download SDF |
| PubChem ID | 16065489 | Appearance | Powder |
| Formula | C16H9N5O | M.Wt | 287.28 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | DMSO : 25 mg/mL (87.02 mM; Need ultrasonic) | ||
| Chemical Name | (9E)-9-prop-2-enoxyiminoindeno[1,2-b]pyrazine-2,3-dicarbonitrile | ||
| SMILES | C=CCON=C1C2=CC=CC=C2C3=NC(=C(N=C31)C#N)C#N | ||
| Standard InChIKey | XLOXSIKLUAMDGU-RCCKNPSSSA-N | ||
| Standard InChI | InChI=1S/C16H9N5O/c1-2-7-22-21-15-11-6-4-3-5-10(11)14-16(15)20-13(9-18)12(8-17)19-14/h2-6H,1,7H2/b21-15+ | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
DUBs-IN-3 Dilution Calculator
DUBs-IN-3 Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.4809 mL | 17.4046 mL | 34.8092 mL | 69.6185 mL | 87.0231 mL |
| 5 mM | 0.6962 mL | 3.4809 mL | 6.9618 mL | 13.9237 mL | 17.4046 mL |
| 10 mM | 0.3481 mL | 1.7405 mL | 3.4809 mL | 6.9618 mL | 8.7023 mL |
| 50 mM | 0.0696 mL | 0.3481 mL | 0.6962 mL | 1.3924 mL | 1.7405 mL |
| 100 mM | 0.0348 mL | 0.174 mL | 0.3481 mL | 0.6962 mL | 0.8702 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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DUBs-IN-3 is a potent deubiquitinase (USP) enzyme inhibitor extracted from reference compound 22c with an IC50 of 0.56 μM for USP8.
References:
[1]. Colombo M, et al. Synthesis and biological evaluation of 9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile analogues as potential inhibitors of deubiquitinating enzymes. ChemMedChem. 2010 Apr 6;5(4):552-8.
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DUB-IN-3 is a potent deubiquitinase (USP) enzyme inhibitor extracted from reference compound 22c with an IC50 of 0.56 μM for USP8.
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