Acrofolione ACAS# 820975-61-9 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
| Cas No. | 820975-61-9 | SDF | Download SDF |
| PubChem ID | N/A | Appearance | Powder |
| Formula | C32H42O9 | M.Wt | 570.7 |
| Type of Compound | Phenols | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Acrofolione A Dilution Calculator
Acrofolione A Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.7522 mL | 8.7612 mL | 17.5223 mL | 35.0447 mL | 43.8059 mL |
| 5 mM | 0.3504 mL | 1.7522 mL | 3.5045 mL | 7.0089 mL | 8.7612 mL |
| 10 mM | 0.1752 mL | 0.8761 mL | 1.7522 mL | 3.5045 mL | 4.3806 mL |
| 50 mM | 0.035 mL | 0.1752 mL | 0.3504 mL | 0.7009 mL | 0.8761 mL |
| 100 mM | 0.0175 mL | 0.0876 mL | 0.1752 mL | 0.3504 mL | 0.4381 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Acrofolione A and B, acetophenone dimers from Acronychia pendunculata, induce an apoptotic effect on human NALM-6 pre-B cell leukaemia cells.[Pubmed:30362134]
J Pharm Pharmacol. 2019 Mar;71(3):348-361.
OBJECTIVES: We investigated the apoptotic activities of Acrofolione A (1) and B (2) isolated from Acronychia pedunculata against a human pre-B cell leukaemia cell line (NALM-6) to explore the apoptosis-related signalling molecules targeted by 1 and 2. METHODS: The apoptosis effects of 1 and 2 in NALM-6 cells were investigated by TUNEL staining, annexin V, mitochondria membrane potential and caspase 3/7 activity. We carried out a protein array to explore the signalling molecules involved in apoptosis comprehensively. KEY FINDINGS: Acrofolione A (1) suppressed the growth of NALM-6, K562 and HPB-ALL cells (IC50 16.7 +/- 1.9, 17.9 +/- 0.3 and 10.1 +/- 0.2 mum, respectively) more effectively than acrofolione B (2). Both compounds time-dependently increased the number of NALM-6 cells with abnormal nuclei, and increased the number of annexin V-positive cells and decreased the mitochondrial membrane potential of NALM-6 cells. Acrofolione A (1) markedly elevated caspase 3/7 activity and increased the number of TUNEL-positive cells. Cells treated with either compound showed enhanced expression of cleaved PARP and cleaved caspase 3 and 7, and reduced survivin protein levels. CONCLUSIONS: Acrofolione A (1) and B (2) may be useful in the treatment of various types of leukaemia.
Cytotoxic prenylated acetophenone dimers from Acronychia pedunculata.[Pubmed:22708987]
J Nat Prod. 2012 Jul 27;75(7):1270-6.
Three new acetophenone dimers or Acronychia-type acetophenones, acropyrone (1), acropyranol A (2), and acropyranol B (3), were isolated from the trunk bark of Acronychia pedunculata and structurally characterized, together with four known acetophenone dimers, acrovestone (4), acrovestenol (5), Acrofolione A (6), and acrofolione B (7), the acetophenone monomer acronyline (8), and four furoquinoline alkaloids. The chemical structures of the new isolated compounds were elucidated unambiguously by spectroscopic data analysis. The cytotoxic activities of the isolated acetophenone dimers were evaluated against the DU145 prostate and A2058 melanoma human cancer cell lines as well as the NHDF normal cell line. Acrovestone (4) and acrovestenol (5) exhibited substantial cytotoxicity, with IC(50) values of 0.38 and 2.8 muM against A2058 melanoma cells as well as 0.93 and 2.7 muM against DU145 prostate cancer cells, respectively.
