Bisandrographolide GCAS# 2699680-69-6 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
| Cas No. | 2699680-69-6 | SDF | Download SDF |
| PubChem ID | N/A | Appearance | Powder |
| Formula | C40H58O9 | M.Wt | 682.98 |
| Type of Compound | Diterpenoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Bisandrographolide G Dilution Calculator
Bisandrographolide G Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.4642 mL | 7.3209 mL | 14.6417 mL | 29.2834 mL | 36.6043 mL |
| 5 mM | 0.2928 mL | 1.4642 mL | 2.9283 mL | 5.8567 mL | 7.3209 mL |
| 10 mM | 0.1464 mL | 0.7321 mL | 1.4642 mL | 2.9283 mL | 3.6604 mL |
| 50 mM | 0.0293 mL | 0.1464 mL | 0.2928 mL | 0.5857 mL | 0.7321 mL |
| 100 mM | 0.0146 mL | 0.0732 mL | 0.1464 mL | 0.2928 mL | 0.366 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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A novel 15-spiro diterpenoid dimer from Andrographis paniculata with inhibitory potential against human carboxylesterase 2.[Pubmed:32120078]
Bioorg Chem. 2020 Apr;97:103680.
The phytochemical investigation of Andrographis paniculata resulted in the isolation of a novel 15-spiro diterpenoid dimer Bisandrographolide G (1). Its structure was determined by 1D and 2D NMR, HRESIMS, electronic circular dichroism (ECD), and TD DFT calculations of ECD spectra. It showed potent inhibitory activity against human carboxylesterase 2 (CES 2) with an IC(50) value of 4.61 +/- 0.23 muM, and it was defined as a mixed-competitive type inhibitor with a Ki value of 8.88 muM based on the inhibition kinetics result. This finding gave us a hit to develop new generation of human CES 2 inhibitors.
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