Carpachromene

CAS# 57498-96-1

Carpachromene

2D Structure

Catalog No. BCN5779----Order now to get a substantial discount!

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Quality Control of Carpachromene

3D structure

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Carpachromene

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Chemical Properties of Carpachromene

Cas No. 57498-96-1 SDF Download SDF
PubChem ID 10449654 Appearance Yellow powder
Formula C20H16O5 M.Wt 336.3
Type of Compound Flavonoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 5-hydroxy-8-(4-hydroxyphenyl)-2,2-dimethylpyrano[3,2-g]chromen-6-one
SMILES CC1(C=CC2=C(O1)C=C3C(=C2O)C(=O)C=C(O3)C4=CC=C(C=C4)O)C
Standard InChIKey YXOATFKTEDZPFL-UHFFFAOYSA-N
Standard InChI InChI=1S/C20H16O5/c1-20(2)8-7-13-16(25-20)10-17-18(19(13)23)14(22)9-15(24-17)11-3-5-12(21)6-4-11/h3-10,21,23H,1-2H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Carpachromene

The herbs of Garcinia xanthochymus

Biological Activity of Carpachromene

Description1. Carpachromene blocks protein expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in LPS-stimulated macrophages, it could be a potential anti-inflammatory agent. 2. Carpachromene exhibits significant cytotoxicity against HepG2, PLC/PRF/5 and Raji cancer cell lines in vitro. 3. Carpachromene shows significant α-glucosidase inhibitory activity.
TargetsNO | TNF-α | NOS | COX

Carpachromene Dilution Calculator

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Carpachromene Molarity Calculator

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Preparing Stock Solutions of Carpachromene

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.9735 mL 14.8677 mL 29.7354 mL 59.4707 mL 74.3384 mL
5 mM 0.5947 mL 2.9735 mL 5.9471 mL 11.8941 mL 14.8677 mL
10 mM 0.2974 mL 1.4868 mL 2.9735 mL 5.9471 mL 7.4338 mL
50 mM 0.0595 mL 0.2974 mL 0.5947 mL 1.1894 mL 1.4868 mL
100 mM 0.0297 mL 0.1487 mL 0.2974 mL 0.5947 mL 0.7434 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Carpachromene

Isolation of tyrosinase inhibitors from Artocarpus heterophyllus and use of its extract as antibrowning agent.[Pubmed:18683821]

Mol Nutr Food Res. 2008 Dec;52(12):1530-8.

A new furanoflavone, 7-(2,4-dihydroxyphenyl)-4-hydroxy-2-(2-hydroxy propan-2-yl)-2, 3-dihydrofuro(3, 2-g)chromen-5-one (artocarpfuranol, 1), together with 14 known compounds, dihydromorin (2), steppogenin (3), norartocarpetin (4), artocarpanone (5), artocarpesin (6), artocarpin (7), cycloartocarpin (8), cycloartocarpesin (9), artocarpetin (10), brosimone I (11), cudraflavone B (12), Carpachromene (13), isoartocarpesin (14), and cyanomaclurin (15) were isolated from the wood of Artocarpus heterophyllus. Their structures were identified by interpretation of MS,( 1)H-NMR,( 13)C-NMR, HMQC, and HMBC spectroscopic data. Among them, compounds 1-6 and 14 showed strong mushroom tyrosinase inhibitory activity with IC(50) values lower than 50 microM, more potent than kojic acid (IC(50) = 71.6 microM), a well-known tyrosinase inhibitor. In addition, extract of A. heterophyllus was evaluated for its antibrowning effect on fresh-cut apple slices. It was discovered that fresh-cut apple slices treated by dipping in solution of 0.03 or 0.05% of A. heterophyllus extract with 0.5% ascorbic acid did not undergo any substantial browning reaction after storage at room temperature for 24 h. The antibrowning effect was significantly better than samples treated with the extract (0.03 or 0.05%) or ascorbic acid (0.5%) alone. The results provide preliminary evidence supporting the potential of this natural extract as antibrowning agent in food systems.

alpha-Glucosidase and 15-Lipoxygenase Inhibitory Activities of Phytochemicals from Calophyllum symingtonianum.[Pubmed:26594765]

Nat Prod Commun. 2015 Sep;10(9):1585-7.

A phytochemical investigation of the crude extracts of the bark and leaves of Calophyllum symingtonianum has resulted in the isolation of inophyllum D, inophyllum H, calanone, isocordato-oblongic acid, amentoflavone, Carpachromene and lupenone. Their chemical structures were elucidated and confirmed by spectroscopic analysis. All flavonoids and coumarins showed significant alpha-glucosidase inhibitory activity, while amentoflavone gave a positive result against 15-lipoxygenase inhibition.

Cytotoxic flavonoids and new chromenes from Ficus formosana f. formosana.[Pubmed:16395655]

Planta Med. 2005 Dec;71(12):1165-7.

Two new chromenes, ficuformodiol A and ficuformodiol B, and nine known compounds including one chromene, spatheliachromen, six flavonoids, obovatin, Carpachromene ( 5), apigenin ( 6), norartocarpetin ( 7), steppogenin, 6-prenylpinocembrin, one benzopyran, chromenylacrylic acid, and one isocoumarin, ( R)-(-)-mellein, were obtained from the cytotoxic chloroform-soluble fraction of the stems of Ficus formosana f. formosana (Moraceae). Their structures were determined by means of spectroscopic analyses. Compounds 5, 6 and 7 exhibited significant cytotoxicity against HepG2, PLC/PRF/5 and Raji cancer cell lines in vitro.

Bioassay guided isolation and identification of anti-inflammatory active compounds from the root of Ficus formosana.[Pubmed:24200240]

J Agric Food Chem. 2013 Nov 20;61(46):11008-15.

Activity-directed fractionation and purification processes were employed to identify the anti-inflammatory active compounds using lipopolysaccharide (LPS)-stimulated mouse macrophage (RAW264.7) in vitro. Air-dried roots of Ficus formosana were extracted with methanol and separated into n-hexane, chloroform, ethyl acetate, n-butanol, and water layers. Among them, the chloroform layer showed strong activity and was subjected to separation and purification by using various chromatographic techniques. Five compounds showing potent activity were identified by comparing spectral data to be beta-sitosterol, stigmasterol, psoralen, kaempferol, Carpachromene, and syringic aldehyde. When macrophages were treated with psoralen and kaempferol together with LPS, a concentration-dependent inhibition of nitric oxide (NO) and tumor necrosis factor (TNF-alpha) productions were detected. Western blotting revealed that kaempferol, psoralen, and Carpachromene blocked protein expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in LPS-stimulated macrophages. The results confirmed that the traditional use of F. formosana could be a potential anti-inflammatory agent.

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