(3beta,24xi)-Cycloartane-3,24,25-triolCAS# 57576-29-1 |
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- Cycloartane-3,24,25-triol
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| Cas No. | 57576-29-1 | SDF | Download SDF |
| PubChem ID | 14314549 | Appearance | Powder |
| Formula | C30H52O3 | M.Wt | 460.7 |
| Type of Compound | Triterpenoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (3S,6R)-6-[(1S,3R,6S,8R,11S,12S,15R,16R)-6-hydroxy-7,7,12,16-tetramethyl-15-pentacyclo[9.7.0.01,3.03,8.012,16]octadecanyl]-2-methylheptane-2,3-diol | ||
| SMILES | CC(CCC(C(C)(C)O)O)C1CCC2(C1(CCC34C2CCC5C3(C4)CCC(C5(C)C)O)C)C | ||
| Standard InChIKey | BKRIPHYESIGPJC-FACDIJBUSA-N | ||
| Standard InChI | InChI=1S/C30H52O3/c1-19(8-11-24(32)26(4,5)33)20-12-14-28(7)22-10-9-21-25(2,3)23(31)13-15-29(21)18-30(22,29)17-16-27(20,28)6/h19-24,31-33H,8-18H2,1-7H3/t19-,20-,21+,22+,23+,24+,27-,28+,29-,30+/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The barks of Aphanamixis polystachya
| Description | 1. Cycloartane-3,24,25-triol has potential for development as an anti-cancer agent against prostate cancer. 2. Cycloartane-3,24,25-triol reduces the viability of PC-3 and DU145 cell lines with IC50 values of 2.226 ± 0.28 μM and 1.67 ± 0.18 μM respectively. |
| Targets | ATPase |
(3beta,24xi)-Cycloartane-3,24,25-triol Dilution Calculator
(3beta,24xi)-Cycloartane-3,24,25-triol Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.1706 mL | 10.853 mL | 21.7061 mL | 43.4122 mL | 54.2652 mL |
| 5 mM | 0.4341 mL | 2.1706 mL | 4.3412 mL | 8.6824 mL | 10.853 mL |
| 10 mM | 0.2171 mL | 1.0853 mL | 2.1706 mL | 4.3412 mL | 5.4265 mL |
| 50 mM | 0.0434 mL | 0.2171 mL | 0.4341 mL | 0.8682 mL | 1.0853 mL |
| 100 mM | 0.0217 mL | 0.1085 mL | 0.2171 mL | 0.4341 mL | 0.5427 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Cycloartane-3,24,25-triol inhibits MRCKalpha kinase and demonstrates promising anti prostate cancer activity in vitro.[Pubmed:23151005]
Cancer Cell Int. 2012 Nov 14;12(1):46.
UNLABELLED: BACKGROUND: Given the high occurrence of prostate cancer worldwide and one of the major sources of the discovery of new lead molecules being medicinal plants, this research undertook to investigate the possible anti-cancer activity of two natural cycloartanes; cycloartane-3,24,25-diol (extracted in our lab from Tillandsia recurvata) and cycloartane-3,24,25-triol (purchased). The inhibition of MRCKalpha kinase has emerged as a potential solution to restoring the tight regulation of normal cellular growth, the loss of which leads to cancer cell formation. METHODS: Kinase inhibition was investigated using competition binding (to the ATP sites) assays which have been previously established and authenticated and cell proliferation was measured using the WST-1 assay. RESULTS: Cycloartane-3,24,25-triol demonstrated strong selectivity towards the MRCKalpha kinase with a Kd50 of 0.26 muM from a total of 451 kinases investigated. Cycloartane-3,24,25-triol reduced the viability of PC-3 and DU145 cell lines with IC50 values of 2.226 +/- 0.28 muM and 1.67 +/- 0.18 muM respectively. CONCLUSIONS: These results will prove useful in drug discovery as Cycloartane-3,24,25-triol has shown potential for development as an anti-cancer agent against prostate cancer.
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