Baccatin IV

CAS# 57672-77-2

Baccatin IV

Catalog No. BCN5785----Order now to get a substantial discount!

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Quality Control of Baccatin IV

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Chemical structure

Baccatin IV

3D structure

Chemical Properties of Baccatin IV

Cas No. 57672-77-2 SDF Download SDF
PubChem ID 15275710 Appearance Powder
Formula C32H44O14 M.Wt 652.7
Type of Compound Diterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name [(1S,2S,3R,4S,7R,9S,10S,11R,12R,15S)-2,4,11,12,15-pentaacetyloxy-1-hydroxy-10,14,17,17-tetramethyl-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-9-yl] acetate
SMILES CC1=C2C(C(C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C)O)OC(=O)C)(CO4)OC(=O)C)OC(=O)C)C)OC(=O)C)OC(=O)C
Standard InChIKey CCJGGIKEFAWREN-WBPIOOJSSA-N
Standard InChI InChI=1S/C32H44O14/c1-14-21(41-15(2)33)12-32(39)28(45-19(6)37)26-30(10,22(42-16(3)34)11-23-31(26,13-40-23)46-20(7)38)27(44-18(5)36)25(43-17(4)35)24(14)29(32,8)9/h21-23,25-28,39H,11-13H2,1-10H3/t21-,22-,23+,25+,26-,27-,28-,30+,31-,32+/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Baccatin IV

The barks of Taxus chinensis

Biological Activity of Baccatin IV

DescriptionBaccatin IV is a natural product from Taxus chinensis.

Protocol of Baccatin IV

Structure Identification
Journal of the Chinese Chemical Society , 2013 , 47 (5) :1125-30.

Taxane Diterpenoids from the Root Bark of Taiwanese Yew[Reference: WebLink]


METHODS AND RESULTS:
Nineteen compounds including taxumairol R (1), taxinine M (2), taxacin (3), paclitaxel (4), 10‐deacetyltaxol A (5), 10‐deacetyl‐7‐epi‐taxol (6), 7‐epi‐taxol (7), taxol C, 10‐deacetyltaxol C, 7β‐xylosyl‐10‐deacetyltaxol (8), taxamairin A (9), taxinine A, 14β‐hydroxytaxusin (10), 5α‐hydroxy‐7β,9α,10β, 13α‐tetraacetoxy‐4(20), 11‐taxadiene, 1‐dehydroxybaccatin‐VI, 1β‐dehydroxybaccatin‐IV, Baccatin IV, baccatin VI and ponasterone A have been isolated and identified from the root bark of Taxus mairei. Among them, compound 1 was a new taxoid and compounds 11 and 7β‐xylosyl‐10‐deacetyltaxol pentaacetate were new derivatives prepared from 14β‐hydroxytaxusin (10) and 8, respectively.
CONCLUSIONS:
Their structures and assignment were established on the basis of 2D‐NMR analysis and chemical methods.

Baccatin IV Dilution Calculator

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Baccatin IV Molarity Calculator

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Preparing Stock Solutions of Baccatin IV

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.5321 mL 7.6605 mL 15.321 mL 30.6419 mL 38.3024 mL
5 mM 0.3064 mL 1.5321 mL 3.0642 mL 6.1284 mL 7.6605 mL
10 mM 0.1532 mL 0.766 mL 1.5321 mL 3.0642 mL 3.8302 mL
50 mM 0.0306 mL 0.1532 mL 0.3064 mL 0.6128 mL 0.766 mL
100 mM 0.0153 mL 0.0766 mL 0.1532 mL 0.3064 mL 0.383 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Baccatin IV

Taxoids from the needles of the Canadian yew.[Pubmed:10872214]

Phytochemistry. 2000 May;54(2):221-30.

Systematic characterization of the taxoids in the needles of Taxus canadensis led to the discovery of seven taxanes along with three known congeners. Their structures were rigorously established by spectroscopic methods as 15-benzoyl-10-deacetyl-2-debenzoyl-10-dehydro-abeo-baccat in III; 15-benzoyl-2-debenzoyl-7, 9-dideacetyl-abeo-baccatin VI; N-acetyl-N-debenzoyltaxol; 7,9,13-trideacetylbaccatin VI; 10-deacetyl-10-glycolylBaccatin IV; 1 beta-hydroxy-10-deacetyl-10-glycolylbaccatin I; and 7-deacetyltaxuspine L. These taxanes, specific to the Canadian yew, were co-isolated with taxacustin, taxagifine and 2-deacetyl-7,10-diacetyl-5-deaminoacyl taxine A previously found in Taxus cuspidata, baccata, and yunnanensis, respectively.

Analysis of taxol and major taxoids in Himalayan yew, Taxus wallichiana.[Pubmed:10551356]

J Chromatogr A. 1999 Oct 15;858(2):239-44.

A reversed-phase column liquid chromatography method for the analysis of taxol, 10-deacetylbaccatin III, Baccatin IV, 1-hydroxybaccatin I, 2-acetoxybrevifoliol, brevifoliol, 2'-deacetoxydecinnamoyltaxinine J and 2'-deacetoxytaxinine J in yew needles has been developed using a Nova-Pak Phenyl column and a binary gradient profile. The various aspects of analysis such as extraction efficiency, detection limits, reproducibility and peak purity were validated using UV-Vis as well as photodiode array detection.

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