Kansuinine BCAS# 57685-46-8 |
Quality Control & MSDS
3D structure
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| Cas No. | 57685-46-8 | SDF | Download SDF |
| PubChem ID | 442050 | Appearance | Powder |
| Formula | C38H42O14 | M.Wt | 722.7 |
| Type of Compound | Diterpenoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| SMILES | CC1C2C(O2)C(C(=O)C(C(C(=C)C(C3C(C(C(C3(C1=O)OC(=O)C)O)(C)O)OC(=O)C)OC(=O)C4=CC=CC=C4)OC(=O)C5=CC=CC=C5)O)(C)C | ||
| Standard InChIKey | JFOILMZFESGPDU-GXRLDEOZSA-N | ||
| Standard InChI | InChI=1S/C38H42O14/c1-18-26(50-33(44)22-14-10-8-11-15-22)24-31(48-20(3)39)37(7,47)35(46)38(24,52-21(4)40)29(42)19(2)28-32(49-28)36(5,6)30(43)25(41)27(18)51-34(45)23-16-12-9-13-17-23/h8-17,19,24-28,31-32,35,41,46-47H,1H2,2-7H3/t19-,24-,25+,26-,27-,28-,31+,32+,35-,37-,38+/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The roots of Euphorbia kansui
| Description | 1. Kansuinine B shows cytotoxic activity. 2. Kansuinine B shows analgesic activity. 3. Treatment with kansuinine B and kansuinine A represents a novel method to block the IL-6-induced effects. |
| Targets | IL Receptor | STAT | ERK | MEK |
Kansuinine B Dilution Calculator
Kansuinine B Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.3837 mL | 6.9185 mL | 13.837 mL | 27.674 mL | 34.5925 mL |
| 5 mM | 0.2767 mL | 1.3837 mL | 2.7674 mL | 5.5348 mL | 6.9185 mL |
| 10 mM | 0.1384 mL | 0.6919 mL | 1.3837 mL | 2.7674 mL | 3.4593 mL |
| 50 mM | 0.0277 mL | 0.1384 mL | 0.2767 mL | 0.5535 mL | 0.6919 mL |
| 100 mM | 0.0138 mL | 0.0692 mL | 0.1384 mL | 0.2767 mL | 0.3459 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Kansuinine A and Kansuinine B from Euphorbia kansui L. inhibit IL-6-induced Stat3 activation.[Pubmed:20379953]
Planta Med. 2010 Oct;76(14):1544-9.
The current study was performed to examine the mechanisms underlying the potential effects of E. KANSUI on IL-6-induced cellular signaling in human hepatoma cells. We found that two diterpenoids, kansuinine A and B, from E. KANSUI have an inhibitory effect on IL-6-induced Stat3 activation by activating ERK1/2. Inhibition of MEK significantly blocked the effects of kansuinine A and B on IL-6-induced Stat3 activation and tyrosine phosphorylation. These results suggest that blocking of IL-6-induced signal transduction is partially due to the sustained activation of ERK1/2 by kansuinine A and B, which in turn results in an increase of Stat3 serine phosphorylation and SOCS-3 expression. Treatment with kansuinine A and B represents a novel method to block these IL-6-induced effects.
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