WAY 629 hydrochlorideSelective 5-HT2C agonist CAS# 57756-44-2 |
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| Cas No. | 57756-44-2 | SDF | Download SDF |
| PubChem ID | 12259556 | Appearance | Powder |
| Formula | C15H19ClN2 | M.Wt | 262.78 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble to 100 mM in DMSO | ||
| SMILES | C1CCC2=C(C1)C3=C4N2CCNCC4=CC=C3.Cl | ||
| Standard InChIKey | PZXUJERSOFOWES-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C15H18N2.ClH/c1-2-7-14-12(5-1)13-6-3-4-11-10-16-8-9-17(14)15(11)13;/h3-4,6,16H,1-2,5,7-10H2;1H | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Selective 5-HT2C agonist. Ki values are 56, 2350, 1575 and 815 nM for human recombinant 5-HT2C, 5-HT2A, 5-HT6 and 5-HT7 receptors respectively. Stimulates intracellular Ca2+ mobilization in CHO cells expressing human 5-HT2C receptors (EC50 = 72 nM). Reduces food intake in rats. |
WAY 629 hydrochloride Dilution Calculator
WAY 629 hydrochloride Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.8055 mL | 19.0273 mL | 38.0546 mL | 76.1093 mL | 95.1366 mL |
| 5 mM | 0.7611 mL | 3.8055 mL | 7.6109 mL | 15.2219 mL | 19.0273 mL |
| 10 mM | 0.3805 mL | 1.9027 mL | 3.8055 mL | 7.6109 mL | 9.5137 mL |
| 50 mM | 0.0761 mL | 0.3805 mL | 0.7611 mL | 1.5222 mL | 1.9027 mL |
| 100 mM | 0.0381 mL | 0.1903 mL | 0.3805 mL | 0.7611 mL | 0.9514 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Cycloalkyl[b][1,4]benzodiazepinoindoles are agonists at the human 5-HT2C receptor.[Pubmed:15109661]
Bioorg Med Chem Lett. 2004 May 17;14(10):2603-7.
Evaluation of selected compounds from our Corporate Compound Library in a human 5-HT(2C) receptor binding assay led to the discovery of WAY-629, a cyclohexyl[b][1,4]benzodiazepinoindole (K(i) 56 nM, E(max) 90%), which is selective for the 5-HT(2C) receptor versus other serotonin receptor subtypes, and dopamine, histamine, adrenergic, and muscarinic receptors. In addition, WAY-629 was active in vivo in a rat model of feeding behavior. An SAR study based on WAY-629 led to compound 11 (K(i) 13 nM, E(max) 102%).
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