Cyclo(Pro-Val)CAS# 5654-87-5 |
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Quality Control & MSDS
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| Cas No. | 5654-87-5 | SDF | Download SDF |
| PubChem ID | 98951 | Appearance | Powder |
| Formula | C10H16N2O2 | M.Wt | 196.25 |
| Type of Compound | Miscellaneous | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 3-propan-2-yl-2,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione | ||
| SMILES | CC(C)C1C(=O)N2CCCC2C(=O)N1 | ||
| Standard InChIKey | XLUAWXQORJEMBD-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C10H16N2O2/c1-6(2)8-10(14)12-5-3-4-7(12)9(13)11-8/h6-8H,3-5H2,1-2H3,(H,11,13) | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Cyclo(Pro-Val) shows cyctoxic, moderate antifungal and weak antitumor activities in vitro, it can inhibit the growth of Bacillus subtilis with the minimal inhibitory concentration (MIC) value of 0.8 g/L. Cyclo(Pro-Val) and cyclo(Pro-Tyr) are toxic to both suspension cells and seedlings of Pinus thunbergii, which may offer some clues to research the mechanism of pine wilt disease caused by pine wood nematode. |
| Targets | Antifection |
| In vitro | Cyclic dipeptide constituents from the mangrove fungus Penicillium oxalicum(No.092007).[Reference: WebLink]Journal of Shenyang Pharmaceutical University, 2007,24(8) :474-8.To study the metabolites of mangrove fungus Penicillium oxalicum from the south China sea and search for new anti-tumor compounds. Antifungal cyclopeptides from Halobacillus litoralis YS3106 of marine origin.[Reference: WebLink]Tetrahedron Lett.,2002, 33(51):6545-8.
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| Structure Identification | J Nematol. 2007 Sep;39(3):243-7.Two Cyclic Dipeptides from Pseudomonas fluorescens GcM5-1A Carried by the Pine Wood Nematode and Their Toxicities to Japanese Black Pine Suspension Cells and Seedlings in vitro.[Pubmed: 19259494]Pseudomonas fluorescens GcM5-1A, isolated from the pine wood nematode (PWN), Bursaphelenchus xylophilus, was cultured in Luria Broth medium (LB). |
Cyclo(Pro-Val) Dilution Calculator
Cyclo(Pro-Val) Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 5.0955 mL | 25.4777 mL | 50.9554 mL | 101.9108 mL | 127.3885 mL |
| 5 mM | 1.0191 mL | 5.0955 mL | 10.1911 mL | 20.3822 mL | 25.4777 mL |
| 10 mM | 0.5096 mL | 2.5478 mL | 5.0955 mL | 10.1911 mL | 12.7389 mL |
| 50 mM | 0.1019 mL | 0.5096 mL | 1.0191 mL | 2.0382 mL | 2.5478 mL |
| 100 mM | 0.051 mL | 0.2548 mL | 0.5096 mL | 1.0191 mL | 1.2739 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Two Cyclic Dipeptides from Pseudomonas fluorescens GcM5-1A Carried by the Pine Wood Nematode and Their Toxicities to Japanese Black Pine Suspension Cells and Seedlings in vitro.[Pubmed:19259494]
J Nematol. 2007 Sep;39(3):243-7.
Pseudomonas fluorescens GcM5-1A, isolated from the pine wood nematode (PWN), Bursaphelenchus xylophilus, was cultured in Luria Broth medium (LB). The clarified culture was extracted with ethyl acetate, and two dipeptides were purified from the extract. The chemical structures of 1 and 2 were identified as cyclo(-Pro-Val-)and cyclo(-Pro-Tyr-), respectively, by MS, (1)H NMR, (13)C NMR,(1)H-(1)H COSY, 1H -(13)C COSY spectra. Bioassay results showed that the two compounds were toxic to both suspension cells and seedlings of Pinus thunbergii, which may offer some clues to research the mechanism of pine wilt disease caused by PWN.
