Hinokiol

CAS# 564-73-8

Hinokiol

Catalog No. BCN5759----Order now to get a substantial discount!

Product Name & Size Price Stock
Hinokiol: 5mg Please Inquire In Stock
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Quality Control of Hinokiol

Number of papers citing our products

Chemical structure

Hinokiol

3D structure

Chemical Properties of Hinokiol

Cas No. 564-73-8 SDF Download SDF
PubChem ID 12310492 Appearance Powder
Formula C20H30O2 M.Wt 302.5
Type of Compound Diterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (2S,4aS,10aR)-1,1,4a-trimethyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthrene-2,6-diol
SMILES CC(C)C1=C(C=C2C(=C1)CCC3C2(CCC(C3(C)C)O)C)O
Standard InChIKey ODFCWXVQZAQDSO-CMKODMSKSA-N
Standard InChI InChI=1S/C20H30O2/c1-12(2)14-10-13-6-7-17-19(3,4)18(22)8-9-20(17,5)15(13)11-16(14)21/h10-12,17-18,21-22H,6-9H2,1-5H3/t17-,18-,20+/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Hinokiol

The barks of Cephalotaxus fortunei Hook. f.

Biological Activity of Hinokiol

Description1. Hinokiol demonstrates potent activity against clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA). 2. Hinokiol has significant inhibitory effects on 5-hydroxy-eicosa-tetra-enoic acid (5-HETE) and leukotriene B(4) (LTB4) formations, suggests that it has anti-inflammatory activity.
TargetsLOX | NO | TNF-α | COX | Antifection

Hinokiol Dilution Calculator

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Hinokiol Molarity Calculator

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Preparing Stock Solutions of Hinokiol

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.3058 mL 16.5289 mL 33.0579 mL 66.1157 mL 82.6446 mL
5 mM 0.6612 mL 3.3058 mL 6.6116 mL 13.2231 mL 16.5289 mL
10 mM 0.3306 mL 1.6529 mL 3.3058 mL 6.6116 mL 8.2645 mL
50 mM 0.0661 mL 0.3306 mL 0.6612 mL 1.3223 mL 1.6529 mL
100 mM 0.0331 mL 0.1653 mL 0.3306 mL 0.6612 mL 0.8264 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Hinokiol

Antibacterial activity of Taxodium ascendens diterpenes against methicillin-resistant Staphylococcus aureus.[Pubmed:25233589]

Nat Prod Commun. 2014 Aug;9(8):1129-30.

One new and seven known diterpenes were identified from an antibacterial chromatographic fraction of Taxodium ascendens. Of these, demethylcryptojaponol (2), 6-hydroxysalvinolone (3), hydroxyferruginol (4), and Hinokiol (5) demonstrated potent activity against clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA). These compounds represent a class of synthetically accessible compounds that could be further developed for treatment of drug-resistant bacterial infections.

The anti-inflammatory activities of an extract and compounds isolated from Platycladus orientalis (Linnaeus) Franco in vitro and ex vivo.[Pubmed:21619922]

J Ethnopharmacol. 2012 Jun 1;141(2):647-52.

ETHNOPHARMACOLOGICAL RELEVANCE: As a Chinese traditional herbal medicine, leaves of Platycladus orientalis (Linnaeus) Franco (LPO) are used to treat coughs, excessive mucus secretion, chronic bronchitis, bronchiectasis, and asthma, etc. The experiments were carried out to investigate their anti-inflammatory properties and mechanisms, which could support the Chinese traditional uses of treating inflammatory airway diseases. MATERIALS AND METHODS: The anti-inflammatory activities of the chloroform fraction (CHL) and pure compounds of LPO were evaluated for their abilities to inhibit pro-inflammatory enzymes in vitro, and production of tumor necrosis factor-alpha (TNF-alpha) and nitric oxide in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. Furthermore, the arachidonic acid metabolites, stimulated by calcium ionophore A23187, were also determined by HPLC. RESULTS: For the first time, the assays of eicosanoids in intact cells showed that the CHL, Hinokiol, and acacetin had significant inhibitory effects on 5-hydroxy-eicosa-tetra-enoic acid (5-HETE) and leukotriene B(4) (LTB4) formations. And cell-free enzyme assays (5-lipoxygenase, leukotriene A(4)-hydrolase, cyclooxgenase-2) demonstrated the potent inhibitory effects of the CHL, Hinokiol and acacetin on 5-lipoxygenase (5-LOX). Then, the inhibitions of the CHL, Hinokiol on NO biosynthesis and the inhibitions of the CHL, 8(14),15-pimaradien-3beta,18-diol, and Hinokiol on TNF-alpha release were also confirmed in the RAW264.7 murine macrophages. CONCLUSION: The data indicate that the inhibitory effects of the CHL and its components (Hinokiol and acacetin) on 5-LOX contribute to the anti-inflammatory activity of LPO. Moreover, the CHL and its components also show beneficial effects on NO and TNF-alpha production. Consequently, these results provide a rationale for LPO's traditional applications in the treatment of inflammatory airway diseases.

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