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11α-Hydroxyandrost-4-ene-3,17-dione

CAS# 564-33-0

11α-Hydroxyandrost-4-ene-3,17-dione

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11α-Hydroxyandrost-4-ene-3,17-dione: 5mg $17 In Stock
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11α-Hydroxyandrost-4-ene-3,17-dione

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Chemical Properties of 11α-Hydroxyandrost-4-ene-3,17-dione

Cas No. 564-33-0 SDF Download SDF
PubChem ID 108106 Appearance Powder
Formula C19H26O3 M.Wt 302.4
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (8S,9S,10R,13S,14S)-11-hydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17-dione
SMILES CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4=O)C)O
Standard InChIKey WSCUHXPGYUMQEX-CRIVMUBDSA-N
Standard InChI InChI=1S/C19H26O3/c1-18-8-7-12(20)9-11(18)3-4-13-14-5-6-16(22)19(14,2)10-15(21)17(13)18/h9,13-15,17,21H,3-8,10H2,1-2H3/t13-,14-,15?,17+,18-,19-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

11α-Hydroxyandrost-4-ene-3,17-dione Dilution Calculator

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Preparing Stock Solutions of 11α-Hydroxyandrost-4-ene-3,17-dione

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.3069 mL 16.5344 mL 33.0688 mL 66.1376 mL 82.672 mL
5 mM 0.6614 mL 3.3069 mL 6.6138 mL 13.2275 mL 16.5344 mL
10 mM 0.3307 mL 1.6534 mL 3.3069 mL 6.6138 mL 8.2672 mL
50 mM 0.0661 mL 0.3307 mL 0.6614 mL 1.3228 mL 1.6534 mL
100 mM 0.0331 mL 0.1653 mL 0.3307 mL 0.6614 mL 0.8267 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 11α-Hydroxyandrost-4-ene-3,17-dione

Obtaining of 11alpha-Hydroxyandrost-4-ene-3,17-dione from Natural Sterols.[Pubmed:28710634]

Methods Mol Biol. 2017;1645:259-269.

Two-step one-pot microbial transformation enables obtaining of valuable steroids that are difficult to produce chemically. Here we describe a method for obtaining 11alpha-hydroxyandrost-4-ene-3,17-dione (11alpha-HAD) from cheap and available natural sterols (phytosterols or cholesterol).11alpha-HAD is a primary adrenal steroid in mammals and also a key precursor in the syntheses of halogenated corticoids. Conventional routes for its obtaining are based on chemical synthesis, or microbial hydroxylation of androst-4-ene-3,17-dione (AD). AD in turn is produced primarily with microbial biotransformation of natural sterols by some actinobacteria.Consequent bioconversions of sterols using two microbial strains in one bioreactor vessel without separation and purification of AD provides high yield of 11alpha-HAD. At the first fermentation step, phytosterol is converted to AD with Mycobacterium neoaurum NRRL 3805B, or relative strains, to yield about 70% (mol/mol). At the second step, AD is almost fully (98%) hydroxylated at the position 11alpha with Aspergillus ochraceus VKM F-830, or other suitable organisms, in the same bioreactor. At the average, 30% (w/w) of the high-purity crystalline 11alpha-HAD can be obtained.The method can be exploited for production of 11alpha-HAD for practical use.

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