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Dehydroabietinol

CAS# 3772-55-2

Dehydroabietinol

Catalog No. BCN5430----Order now to get a substantial discount!

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Quality Control of Dehydroabietinol

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Chemical structure

Dehydroabietinol

3D structure

Chemical Properties of Dehydroabietinol

Cas No. 3772-55-2 SDF Download SDF
PubChem ID 107171 Appearance Powder
Formula C20H30O M.Wt 286.5
Type of Compound Diterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (1,4a-dimethyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthren-1-yl)methanol
SMILES CC(C)C1=CC2=C(C=C1)C3(CCCC(C3CC2)(C)CO)C
Standard InChIKey WSKGRAGZAQRSED-UHFFFAOYSA-N
Standard InChI InChI=1S/C20H30O/c1-14(2)15-6-8-17-16(12-15)7-9-18-19(3,13-21)10-5-11-20(17,18)4/h6,8,12,14,18,21H,5,7,9-11,13H2,1-4H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Dehydroabietinol

The barks of Pinus yunnanensis.

Biological Activity of Dehydroabietinol

Description1. Dehydroabietinol inhibits growth of chloroquine-sensitive as well as chloroquine-resistant strains of Plasmodium falciparum cultivated in erythrocytes in vitro (IC 50 26-27 microM).
TargetsAntifection

Dehydroabietinol Dilution Calculator

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Dehydroabietinol Molarity Calculator

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Preparing Stock Solutions of Dehydroabietinol

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.4904 mL 17.452 mL 34.904 mL 69.808 mL 87.26 mL
5 mM 0.6981 mL 3.4904 mL 6.9808 mL 13.9616 mL 17.452 mL
10 mM 0.349 mL 1.7452 mL 3.4904 mL 6.9808 mL 8.726 mL
50 mM 0.0698 mL 0.349 mL 0.6981 mL 1.3962 mL 1.7452 mL
100 mM 0.0349 mL 0.1745 mL 0.349 mL 0.6981 mL 0.8726 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Dehydroabietinol

Possible artefacts in the in vitro determination of antimalarial activity of natural products that incorporate into lipid bilayer: apparent antiplasmodial activity of dehydroabietinol, a constituent of Hyptis suaveolens.[Pubmed:12094303]

Planta Med. 2002 Jun;68(6):547-9.

Dehydroabietinol isolated from Hyptis suaveolens (L.) Poit. was found to inhibit growth of chloroquine-sensitive as well as chloroquine-resistant strains of Plasmodium falciparum cultivated in erythrocytes in vitro (IC 50 26-27 microM). However, erythrocytes exposed to Dehydroabietinol were transformed in a dose-dependent manner towards spherostomatocytic forms with concomitant formation of endovesicles, as disclosed by transmission electron microscopy. The erythrocyte shape alterations caused by Dehydroabietinol correlated well with its apparent IC 50 value. Thus, Dehydroabietinol incorporates into the erythrocyte membrane, and since invasion and survival of Plasmodium parasites is known to depend on the function of the erythrocyte membrane, the observed antiplasmodial effect of Dehydroabietinol is presumably an indirect effect on the host cell. Because of these findings, microscopic investigations should be generally used to support claims of antimalarial effects of apolar natural products.

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