Deoxycalyciphylline BCAS# 619326-74-8 |
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- Deoxyisocalyciphylline B
Catalog No.:BCN4146
CAS No.:619326-75-9
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| Cas No. | 619326-74-8 | SDF | Download SDF |
| PubChem ID | 10871573 | Appearance | Powder |
| Formula | C22H31NO2 | M.Wt | 341.5 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| SMILES | CC1CN2C3C(CCC4C3=CCC4)C5(C6(C2C1CC6)CCC(=O)O5)C | ||
| Standard InChIKey | NGQSEZXJVMCXSC-AJXLCOHYSA-N | ||
| Standard InChI | InChI=1S/C22H31NO2/c1-13-12-23-19-16-5-3-4-14(16)6-7-17(19)21(2)22(11-9-18(24)25-21)10-8-15(13)20(22)23/h5,13-15,17,19-20H,3-4,6-12H2,1-2H3/t13-,14-,15-,17+,19+,20+,21-,22+/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The herbs of Daphniphyllum calycinum
| Description | 1. Deoxycalyciphylline B exhibits hepatic toxicity. 2. Deoxycalyciphylline B and Methyl homosecodaphniphyllate show different inhibitory effects on thephenoloxidase (PO) of Spodoptera exigua (Hbner) and the inhibitor concentrations leading to 50% (IC50) activity lost are estimated to be 2.439 mmol·L-1 for deoxycalyciphyllineB and 0.879mmol·L-1 for methyl homosecodaphniphyllate,respectively. |
Deoxycalyciphylline B Dilution Calculator
Deoxycalyciphylline B Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.9283 mL | 14.6413 mL | 29.2826 mL | 58.5652 mL | 73.2064 mL |
| 5 mM | 0.5857 mL | 2.9283 mL | 5.8565 mL | 11.713 mL | 14.6413 mL |
| 10 mM | 0.2928 mL | 1.4641 mL | 2.9283 mL | 5.8565 mL | 7.3206 mL |
| 50 mM | 0.0586 mL | 0.2928 mL | 0.5857 mL | 1.1713 mL | 1.4641 mL |
| 100 mM | 0.0293 mL | 0.1464 mL | 0.2928 mL | 0.5857 mL | 0.7321 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Deoxycalyciphylline B, a hepatotoxic alkaloid from Daphniphyllum calycinum.[Pubmed:22890169]
Molecules. 2012 Aug 13;17(8):9641-51.
Daphniphyllum calycinum (DC), a main component of Chinese patent drug Fengliao-Changweikang, is effectively used to cure bowel disease in the clinic. It was recorded that DC possessed slight toxicity, which was caused by the alkaloids existing in its extract. Unfortunately, to date the toxicity level and toxic constituents are still unclear. The present study is designed to illustrate the acute toxicity and induced organ damages of the total alkaloids as well as to determine the toxic constituents. Based on the above studies, not only was the acute toxicity determined but also hepatic toxicity was characterized by increased plasma biomarkers of ALT and AST and liver cell inflammatory infiltrate as well necrosis that was firstly observed. Significantly, Deoxycalyciphylline B exhibited exactly the same hepatic toxicity so it was identified as the main toxic constituent in DC. An obvious dose-effect relationship between the toxic compound and induced hepatic injuries was also observed. Moreover, the Chinese patent drug Fengliao-Changweikang contained low levels of the toxic compound, compared with the total alkaloids. Therefore, this Chinese patent drug could be regarded to be safe in this point of view.
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