DeoxylimoninCAS# 989-23-1 |
Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 989-23-1 | SDF | Download SDF |
| PubChem ID | 100026 | Appearance | Powder |
| Formula | C26H30O7 | M.Wt | 454.5 |
| Type of Compound | Triterpenoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 18-(furan-3-yl)-9,9,13,19-tetramethyl-4,8,17-trioxapentacyclo[11.8.0.02,7.02,10.014,19]henicos-14-ene-5,12,16-trione | ||
| SMILES | CC1(C2CC(=O)C3(C(C24COC(=O)CC4O1)CCC5(C3=CC(=O)OC5C6=COC=C6)C)C)C | ||
| Standard InChIKey | QUTATOGBENCRSS-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C26H30O7/c1-23(2)16-9-18(27)25(4)15(26(16)13-31-20(28)11-19(26)33-23)5-7-24(3)17(25)10-21(29)32-22(24)14-6-8-30-12-14/h6,8,10,12,15-16,19,22H,5,7,9,11,13H2,1-4H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Deoxylimonin Dilution Calculator
Deoxylimonin Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.2002 mL | 11.0011 mL | 22.0022 mL | 44.0044 mL | 55.0055 mL |
| 5 mM | 0.44 mL | 2.2002 mL | 4.4004 mL | 8.8009 mL | 11.0011 mL |
| 10 mM | 0.22 mL | 1.1001 mL | 2.2002 mL | 4.4004 mL | 5.5006 mL |
| 50 mM | 0.044 mL | 0.22 mL | 0.44 mL | 0.8801 mL | 1.1001 mL |
| 100 mM | 0.022 mL | 0.11 mL | 0.22 mL | 0.44 mL | 0.5501 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- Dencichine
Catalog No.:BCX0482
CAS No.:5302-45-4
- Schisandrathera D
Catalog No.:BCX0481
CAS No.:2694046-04-1
- Schisanhenol B
Catalog No.:BCX0480
CAS No.:102681-52-7
- Indole-3-acetic acid β-D-glucopyranosyl ester
Catalog No.:BCX0479
CAS No.:19817-95-9
- Gypenoside LXXV
Catalog No.:BCX0478
CAS No.:110261-98-8
- Sinapyl alcohol
Catalog No.:BCX0477
CAS No.:537-33-7
- Rankinidine
Catalog No.:BCX0476
CAS No.:106466-66-4
- Methyl indole-3-acetate
Catalog No.:BCX0475
CAS No.:1912-33-0
- Galanal B
Catalog No.:BCX0474
CAS No.:104113-52-2
- Labda-8(17),12E,14-trien-16,15-olide
Catalog No.:BCX0473
CAS No.:917078-10-5
- Mulberrofuran V
Catalog No.:BCX0472
CAS No.:174423-49-5
- 6'-O-p-Hydroxybenzoylgastrodin
Catalog No.:BCX0471
CAS No.:1551525-70-2
- 5-Methoxydadahol A
Catalog No.:BCX0484
CAS No.:2410566-84-4
- 4-(3-Hydroxydecyl)phenol
Catalog No.:BCX0485
CAS No.:1465124-36-0
- Oxyphyllone D
Catalog No.:BCX0486
CAS No.:1190094-25-7
- Rugulolide A
Catalog No.:BCX0487
CAS No.:3002032-70-1
- Rugulolide B
Catalog No.:BCX0488
CAS No.:3002032-71-2
- 2,4-Dihydroxybezaldehyde
Catalog No.:BCX0489
CAS No.:95-01-2
- Ethyl 2,4-dihydroxybenzoate
Catalog No.:BCX0490
CAS No.:4143-00-4
- 7-epi-α-Cyperone
Catalog No.:BCX0491
CAS No.:547-26-2
- 4-Hydroxy-4-methylcyclohex-2-en-1-one
Catalog No.:BCX0492
CAS No.:70150-56-0
- Sanggenon E
Catalog No.:BCX0493
CAS No.:81381-69-3
- Rugulolide D
Catalog No.:BCX0494
CAS No.:3002032-69-8
- Sanggenol C
Catalog No.:BCX0495
CAS No.:174423-32-6
A practical synthesis of amino limonin/deoxylimonin derivatives as effective mitigators against inflammation and nociception.[Pubmed:33479680]
RSC Med Chem. 2020 Jun 16;11(7):843-847.
A practical synthetic route, consisting of 5 steps, has been developed and applied successfully for converting limonin/Deoxylimonin into the corresponding amino derivatives I- 5a-I- 5e and II- 5a-II- 5e. Deoxylimonin analogs II- 5a and II- 5b bearing an open A ring structure underwent ring closure reaction by employing the Mitsunobu procedure to afford II- 6a and II- 6b. All of the 12 newly synthesized compounds were subjected to preliminary screening for evaluating their inflammation and nociception inhibition efficacy. The most promising compounds, I- 5b and II- 5d, were selected for further investigation by a carrageenan-induced mouse paw edema model, both of which displayed a dose-response dependent manner and demonstrated superior anti inflammation capacity to that of indomethacin in the first 2 hours.
Discovery of deoxylimonin delta-lactam derivative with favorable anti-inflammation and antinociception efficacy from chemical modified limonin/deoxylimonin analogs.[Pubmed:32371249]
Bioorg Chem. 2020 Jul;100:103886.
Chemical modifications on the A ring of limonin (1) and Deoxylimonin (2) afforded 28 structural characterized derivatives, which were firstly subjected to preliminary in vivo analgesic and anti-inflammatory screen by mice model. The most promising candidate, Deoxylimonin analog II-B-2 (70 mg/kg) with 3,4-dimethoxyphenylethyl moiety substitued delta-lactam in the A ring, exhibited better analgesic activity than aspirin (200 mg/kg) and stronger anti-inflammatory efficacy than naproxen (150 mg/kg). Further in vivo evaluation confirmed its advantage over limonin and showed dose-response dependent manner, and follow-up research suggested that the anti-inflammatory effect of compound II-B-2 may be attributed to the downregulation of cyclooxygenase 2 expression and the suppression of prostaglandin E(2) formation.
Further studies on the anticancer activity of citrus limonoids.[Pubmed:15264934]
J Agric Food Chem. 2004 Jul 28;52(15):4908-12.
Research in this laboratory has shown that some citrus limonoids can inhibit the development of 7,12-dimethylbenz[a]anthracene-induced oral tumors. The data from these studies have suggested that certain rings in the limonoid nucleus may be critical to antineoplastic activity. Using the hamster cheek pouch model, three new limonoids (ichangensin, Deoxylimonin, and obacunone) have now been tested for cancer chemopreventive activity. In the first experiment, it was found that the treatments with ichangensin had no effect on tumor number or burden. In the second experiment, obacunone reduced tumor number and burden by 25 and 40%, respectively, whereas Deoxylimonin reduced tumor number and burden by 30 and 50%, respectively. The results with Deoxylimonin were significant, p < 0.05. Overall, the data indicated that changes in the A ring of the limonoid nucleus can lead to a loss of anticancer activity, whereas changes in the D ring can be tolerated without any apparent loss of biological activity.
