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Diclofensine hydrochloride

CAS# 34041-84-4

Diclofensine hydrochloride

Catalog No. BCC5541----Order now to get a substantial discount!

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Chemical structure

Diclofensine hydrochloride

3D structure

Chemical Properties of Diclofensine hydrochloride

Cas No. 34041-84-4 SDF Download SDF
PubChem ID 157489 Appearance Powder
Formula C17H18Cl3NO M.Wt 358.69
Type of Compound N/A Storage Desiccate at -20°C
Synonyms Ro 8-4650 hydrochloride
Solubility H2O : ≥ 52 mg/mL (144.97 mM)
*"≥" means soluble, but saturation unknown.
Chemical Name 4-(3,4-dichlorophenyl)-7-methoxy-2-methyl-3,4-dihydro-1H-isoquinoline;hydrochloride
SMILES CN1CC(C2=C(C1)C=C(C=C2)OC)C3=CC(=C(C=C3)Cl)Cl.Cl
Standard InChIKey PEHOXCSPLOXNOK-UHFFFAOYSA-N
Standard InChI InChI=1S/C17H17Cl2NO.ClH/c1-20-9-12-7-13(21-2)4-5-14(12)15(10-20)11-3-6-16(18)17(19)8-11;/h3-8,15H,9-10H2,1-2H3;1H
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Diclofensine hydrochloride Dilution Calculator

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Diclofensine hydrochloride Molarity Calculator

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Preparing Stock Solutions of Diclofensine hydrochloride

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.7879 mL 13.9396 mL 27.8792 mL 55.7585 mL 69.6981 mL
5 mM 0.5576 mL 2.7879 mL 5.5758 mL 11.1517 mL 13.9396 mL
10 mM 0.2788 mL 1.394 mL 2.7879 mL 5.5758 mL 6.9698 mL
50 mM 0.0558 mL 0.2788 mL 0.5576 mL 1.1152 mL 1.394 mL
100 mM 0.0279 mL 0.1394 mL 0.2788 mL 0.5576 mL 0.697 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Background on Diclofensine hydrochloride

Diclofensine(Ro-8-4650) is a potent inhibitor of monoamine reuptake, blocking the uptake of dopamine, noradrenaline, and serotonin by rat brain synaptosomes with IC50 values of 0.74, 2.3, and 3.7 nM, respectively. IC50 value: Target: Dopamine reuptake inhibitor The action of diclofensine on peripheral neuronal adrenergic function was studied through tests of the blood pressure response to NE, tyramine, and phenylephrine (PE). The blood pressure response to NE was enhanced and that to tyramine was decreased by diclofensine, as a result of its inhibitive action on peripheral neuronal amine uptake [2]. Diclofensine, in concentrations of 0.01, 0.1 and 1 microM caused a marked decrease of 3H-DA uptake. In addition, it was unable to stimulate basal endogenous DA release which, on the contrary, was elicited by d-amphetamine in the same concentration (50 microM). On the other hand, diclofensine (50 microM) caused a 3 fold enhancement of K+-evoked DA release [3].

References:
[1]. Hyttel J, et al. Neurochemical profile of Lu 19-005, a potent inhibitor of uptake of dopamine, noradrenaline, and serotonin. J Neurochem. 1985 May;44(5):1615-22. [2]. Gasic S, et al. Effect of diclofensine, a novel antidepressant, on peripheral adrenergic function. Clin Pharmacol Ther. 1986 May;39(5):582-5. [3]. Di Renzo G, et al. Pure uptake blockers of dopamine can reduce prolactin secretion: studies with diclofensine. Life Sci. 1988;42(21):2161-9.

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Description

Diclofensine hydrochloride (Ro-8-4650 hydrochloride) is a potent inhibitor of monoamine reuptake, blocking the uptake of dopamine, noradrenaline, and serotonin by rat brain synaptosomes with IC50 values of 0.74, 2.3, and 3.7 nM, respectively.

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