Vinorine

CAS# 34020-07-0

Vinorine

Catalog No. BCN4649----Order now to get a substantial discount!

Product Name & Size Price Stock
Vinorine: 5mg $903 In Stock
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Quality Control of Vinorine

Number of papers citing our products

Chemical structure

Vinorine

3D structure

Chemical Properties of Vinorine

Cas No. 34020-07-0 SDF Download SDF
PubChem ID 5281974 Appearance Powder
Formula C21H22N2O2 M.Wt 334.42
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name [(1R,10S,12R,13E,16S,18R)-13-ethylidene-8,15-diazahexacyclo[14.2.1.01,9.02,7.010,15.012,17]nonadeca-2,4,6,8-tetraen-18-yl] acetate
SMILES CC=C1CN2C3CC1C4C2CC5(C4OC(=O)C)C3=NC6=CC=CC=C56
Standard InChIKey CLDVMRAEPFQOSD-WEOXKLFPSA-N
Standard InChI InChI=1S/C21H22N2O2/c1-3-12-10-23-16-8-13(12)18-17(23)9-21(20(18)25-11(2)24)14-6-4-5-7-15(14)22-19(16)21/h3-7,13,16-18,20H,8-10H2,1-2H3/b12-3-/t13-,16-,17-,18?,20+,21+/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Vinorine

The root of Rauvolfia serpentina

Biological Activity of Vinorine

Description1. Vinorine is a direct biosynthetic precursor along the complex pathway to the monoterpenoid indole alkaloid ajmaline, an antiarrhythmic drug from the Indian medicinal plant Rauvolfia serpentina.

Vinorine Dilution Calculator

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Vinorine Molarity Calculator

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Preparing Stock Solutions of Vinorine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.9903 mL 14.9513 mL 29.9025 mL 59.805 mL 74.7563 mL
5 mM 0.5981 mL 2.9903 mL 5.9805 mL 11.961 mL 14.9513 mL
10 mM 0.299 mL 1.4951 mL 2.9903 mL 5.9805 mL 7.4756 mL
50 mM 0.0598 mL 0.299 mL 0.5981 mL 1.1961 mL 1.4951 mL
100 mM 0.0299 mL 0.1495 mL 0.299 mL 0.5981 mL 0.7476 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Vinorine

Acetyltransfer in natural product biosynthesis--functional cloning and molecular analysis of vinorine synthase.[Pubmed:15110860]

Bioorg Med Chem. 2004 May 15;12(10):2787-95.

Vinorine synthase (EC 2.3.1.160) catalyses the acetyl-CoA- or CoA-dependent reversible formation of the alkaloids Vinorine (or 11-methoxy-Vinorine) and 16-epi-vellosimine (or gardneral). The forward reaction leads to Vinorine, which is a direct biosynthetic precursor along the complex pathway to the monoterpenoid indole alkaloid ajmaline, an antiarrhythmic drug from the Indian medicinal plant Rauvolfia serpentina. Based on partial peptide sequences a cDNA clone was isolated and functionally expressed in Escherichia coli. The Km values of the native enzyme for gardneral and acetyl-CoA were determined to be 7.5 and 57 microM. The amino acid sequence of Vinorine synthase has highest level of identity (28-31%) to that of Papaver salutaridinol acetyltransferase, Fragaria alcohol acyltransferase, and Catharanthus deacetylvindoline acetyltransferase involved in morphine, flavor, and vindoline biosynthesis, respectively. Vinorine synthase is a novel member of the BAHD superfamily of acyltransferases. Site-directed mutagenesis of 13 amino acid residues provided clear evidence that both, His160 and Asp164 of the consensus sequence HxxxD belong to the catalytic center. The mutations also showed that an amino acid triad is not characteristic of Vinorine synthase. The experiments demonstrated the importance of the conserved motif SxL/I/VD near the N-terminus and the consensus sequence DFGWG near the C-terminal.

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