Dopamine Receptor - Neuroscience

Cat.No. Product Name Information

BCN5983 Rotundine Rotundine (L-tetrahydropalmatine, L-THP) is a selective dopamine D1 receptor antagonist with IC50 of 166 nM.

BCC6991 CY 208-243 CY 208-243 is a selective dopamine D1 receptor agonist which exhibits antiparkinsonian activity.

BCC5250 Talipexole Talipexole (B-HT920) is a dopamine agonist that has been proposed as an antiparkinsonian agent.

BCN2181 Pramipexole dihydrochloride Pramipexole dihydrochloride is a partial/full D2S, D2L, D3, D4 receptor agonist with a Ki of 3.9, 2.2, 0.5 and 5.1 nM for D2S, D2L, D3, D4 receptor, respectively.

BCC4467 Pramipexole Pramipexole is a dopamine agonist of the non-ergoline class indicated for treating Parkinson's disease (PD) and restless legs syndrome (RLS).

BCC1528 Dexpramipexole dihydrochloride Dexpramipexole dihydrochloride ((R)-Pramipexole dihydrochloride) is a neuroprotective agent and weak non-ergoline dopamine agonist.

BCC1527 Dexpramipexole Dexpramipexole(KNS-760704), also known as R-(+)-Pramipexole, is a neuroprotective agent and weak non-ergoline dopamine agonist. IC50 Value:

BCC7116 Roxindole hydrochloride

BCC7121 SKF 83566 hydrobromide

BCC1454 Cariprazine hydrochloride Cariprazine hydrochloride is a novel antipsychotic drug candidate that exhibits high affinity for the D3 (Ki=0.085 nM) and D2 (Ki=0.49 nM) receptors, and moderate affinity for the 5-HT1A receptor (Ki=2.6 nM).

BCC1877 Quetiapine Quetiapine is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects.

BCN5339 Quetiapine fumarate Quetiapine hemifumarate is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine hemifumarate is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine hemifumarate has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects. Quetiapine fumarate

BCC4469 PD128907 HCl PD 128907 HCl is a potent and selective dopamine D3 receptor agonist, with EC50 of 0.64 nM, exhibits 53-fold selectivity over dopamine D2 receptor.

BCC3753 Chlorprothixene Chlorprothixene has strong binding affinities to dopamine and histamine receptors, such as D1, D2, D3, D5, H1, 5-HT2, 5-HT6 and 5-HT7, with Ki of 18 nM, 2.96 nM, 4.56 nM, 9 nM, 3.75 nM, 9.4 nM, 3 nM and 5.6 nM, respectively.

BCC6752 3'-Fluorobenzylspiperone maleate

BCC6353 PAOPA PAOPA

BCC1968 ST-836 ST-836 is a dopamine receptor ligand; Antiparkinsonian agent. ST-836

BCC7278 Carmoxirole hydrochloride Carmoxirole hydrochloride (EMD 45609 hydrochloride) is a selective, peripherally acting dopamine D2 receptor agonist and exhibits antihypertensive activities in vivo.

BCC6183 Mephedrone hydrochloride

BCC6790 (+)-UH 232 maleate

BCC7887 SB 277011A dihydrochloride SB-277011 dihydrochloride (SB-277011A dihydrochloride) is a potent, selective, orally bioavailable and brain penetrate dopamine D3 receptor antagonist, with pKis of 8.0, 6.0, <5.2 and 5.9 for D3, D2, 5-HT1B, and 5-HT1D receptors, respectively.

BCC7837 NPEC-caged-dopamine

BCC7818 GSK 789472 hydrochloride

BCC6849 SCH 23390 hydrochloride SCH-23390 hydrochloride (R-(+)-SCH-23390 hydrochloride) is a potent and selective dopamine D1-like receptor antagonist with Kis of 0.2 nM and 0.3 nM for the D1 and D5 receptor, respectively. SCH-23390 hydrochloride is a potent and high efficacy human 5-HT2C receptor agonist with a Ki of 9.3 nM. SCH-23390 hydrochloride also binds with high affinity to the 5-HT2 and 5-HT1C receptors. SCH-23390 hydrochloride inhibits G protein-coupled inwardly rectifying potassium (GIRK) channels with an IC50 of 268 nM. SCH 23390 hydrochloride

BCC5034 Aripiprazole Aripiprazole (OPC-14597) is a human 5-HT1A receptor partial agonist with a Ki of 4.2 nM.

BCC7104 A 68930 hydrochloride Potent, selective D1-like agonist

BCC6224 A 412997 dihydrochloride Selective D4 agonist

BCC6845 3-CPMT 3-CPMT

BCC1969 ST-836 hydrochloride

BCC3834 Paliperidone Paliperidone (9-hydroxyrisperidone) is a dopamine antagonist of the atypical antipsychotic class of medications.

BCC6898 Piribedil dihydrochloride

BCC7159 A 77636 hydrochloride Potent, selective D1-like agonist. Orally active

BCC4251 Haloperidol hydrochloride Haloperidol hydrochloride is a potent dopamine D2 receptor antagonist, widely used as an antipsychotic.

BCC6835 (RS)-(±)-Sulpiride Sulpiride is a D2 receptor a antagonist, an atypical antipsychotic drug of the benzamide class, used mainly in the treatment of psychosis associated with schizophrenia and major depressive disorder, and sometimes used in low dosage to treat anxiety and mild depression. (RS)-(±)-Sulpiride

BCC7424 OSU 6162 hydrochloride

BCC5681 Dihydrexidine hydrochloride (+)-Dihydrexidine hydrochloride ((+)-DAR-0100 hydrochloride) is a dopamine D1 receptor agonist with an EC50 of 72± 21 nM.

BCC6941 GR 103691 GR 103691 is a potent, selective dopamine D3 receptor antagonist with a Ki value of 0.4 nM. GR 103691 shows more than 100-fold selectivity for human dopamine human (h)D3 over hD4 and hD1 sites.

BCN2599 L-Stepholidine L-Stepholidine (Stepholidine), an alkaloid extract of the Chinese herb Stephania intermedia, is the first compound known to exhibit mixed dopamine D1 receptor agonist/

BCC7467 PNU 96415E

BCC7879 Sonepiprazole

BCC4887 Ambrisentan Ambrisentan is a selective ET type A receptor (ETAR) antagonist.

BCC7636 NGD 94-1

BCC4112 Sumanirole maleate Sumanirole maleate (U-95666E; PNU-95666E) is a highly selective D2 receptor full agonist with an ED50 of about 46 nM. Sumanirole was developed for the treatment of Parkinson's disease and restless leg syndrome.

BCC7435 NGB 2904

BCC7330 Ro 10-5824 dihydrochloride Ro 10-5824 dihydrochloride is a selective dopamine D4 receptor partial agonist, with Ki of 5.2 nM.

BCC4466 Pramipexole 2HCl Monohydrate Pramipexole 2HCl Monohydrateis a novel non-ergoline dopamine (DA) agonist, used to treat Parkinson's disease.

BCC6848 SKF 38393 hydrobromide

BCC6760 7-Hydroxy-PIPAT maleate

BCC7923 JHW 007 hydrochloride

BCC6846 3α-Bis-(4-fluorophenyl) methoxytropane hydrochloride

BCC6753 BTCP maleate

BCC4495 Sitaxentan sodium Sitaxsentan sodium (IPI 1040 sodium; TBC11251 sodium) is an orally active, highly selective antagonist of endothelin A receptors.

BCC7702 PD 168568 dihydrochloride

BCC5967 Pemoline

BCC8052 SB269652 SB269652 is the first drug-like allosteric modulator of the dopamine D2 receptor (D2R); a new chemical probe that can differentiate D2R monomers from dimers or oligomers depending on the observed pharmacology.

BCC1928 SB-277011 SB-277011 is a potent and delective dopamine D3 receptor antagonist (pKi values are 8.0, 6.0, 5.0 and <5.2 for D3, D2, 5-HT1D and 5-HT1B respectively); brain penetrant.

BCC6642 Bromocriptine mesylate Bromocriptine mesylate is a potent dopamine D2/D3 receptor agonist, which binds D2 dopamine receptor with pKi of 8.05±0.2.

BCC7029 U 99194 maleate

BCC4463 Levosulpiride Levosulpiride (RV-12309) is the (S)-enantiomer of sulpiride, which is a D2 receptor a antagonist, an atypical antipsychotic drug of the benzamide class.

BCC7851 Flupenthixol dihydrochloride Flupentixol dihydrochloride, a thioxanthene drug, is used in therapy of schizophrenia as well as in anxiolytic and depressive disorders.

BCC5671 2-CMDO 2-CMDO

BCC7664 PNU 177864 hydrochloride

BCC7148 LE 300 LE 300

BCC5818 Threo-methylphenidate hydrochloride

BCC7144 SKF 77434 hydrobromide

BCC7250 (R)-(-)-Apomorphine hydrochloride

BCC7226 Nomifensine Nomifensine maleate is a selective inhibitor of dopamine uptake, used in adult attention deficit disorder.

BCC5541 Diclofensine hydrochloride Diclofensine hydrochloride (Ro-8-4650 hydrochloride) is a potent inhibitor of monoamine reuptake, blocking the uptake of dopamine, noradrenaline, and serotonin by rat brain synaptosomes with IC50 values of 0.74, 2.3, and 3.7 nM, respectively.

BCC1743 Metoclopramide Metoclopramide is a dopamine D2 antagonist that is used as an antiemetic.

BCC5325 9-Hydroxycalabaxanthone hydrate Rotundine is an antagonist of dopamine D1, D2 and D3 receptors with IC50s of 166 nM, 1.4 μM and 3.3 μM, respectively. Rotundine is also an antagonist of 5-HT1A with an IC50 of 370 nM.

BCC5942 D-Amphetamine sulfate

BCC6679 AMI-193 Selective 5-HT2 antagonist AMI-193

BCC4909 Haloperidol Haloperidol is a potent dopamine D2 receptor antagonist, widely used as an antipsychotic.

BCC5943 Cocaine hydrochloride

BCC4461 Domperidone Domperidone is a dopamine blocker and an antidopaminergic reagent.

BCC5037 Clozapine Clozapine (HF 1854) is an antipsychotic used to treat schizophrenia. Clozapine is a potent antagonist of dopamine and a number of other receptors, with a Ki of 9.5 nM for M1 receptor. Clozapine is also a potent and selective agonist at the muscarinic M4 receptor (EC50=11 nM).

BCC7293 ABT 724 trihydrochloride ABT-724 trihydrochloride is a potent and highly selective dopamine D4 receptor agonist with an EC50 of 12.4 nM for human dopamine D4 receptor. ABT-724 trihydrochloride is a potent partial agonist at the rat D4 (EC50 of 14.3 nM) and the ferret D4 receptor (EC50 of 23.2 nM), and has no effect on dopamine D1, D2, D3, or D5 receptors. ABT-724 trihydrochloride could be useful for the treatment of erectile dysfunction and has favorable side-effect profile. ABT 724 trihydrochloride

BCN1098 Levodopa L-DOPA (Levodopa) is an orally active metabolic precursor of neurotransmitters dopamine. L-DOPA can cross the blood-brain barrier and is converted into dopamine in the brain. L-DOPA has anti-allodynic effects and the potential for Parkinson's disease.

BCC6769 4-Phenyl-1,2,3,4-tetrahydroisoquinoline hydrochloride

BCN2195 Dopamine hydrochloride Dopamine HCl is a catecholamine neurotransmitter present in a wide variety of animals,And a dopamine D1-5 receptors agonist.

BCC6526 SKF38393 HCl SKF 38393 hydrochloride is a selective agonist of the dopamine D1 receptor (D1DR) with an IC50 of 110 nM.

BCC6919 PD 168077 maleate PD-168077 maleate is a selective dopamine D4 receptor agonist, with a Ki of 9 nM.

BCC4592 LY404039 LY404039 is an inhibitor for mGluR1(Ki=149 nM) and mGluR2(Ki= 92 nM), which can also inhibit dopamine receptor.

BCC7403 6-Hydroxydopamine hydrobromide Oxidopamine hydrobromide (6-OHDA hydrobromide), an antagonist of the neurotransmitter dopamine, is a widely used neurotoxin that selectively destroys dopaminergic neurons.

BCC4464 Pergolide mesylate Pergolide mesylate is an antiparkinsonian agent which functions as a dopaminergic agonist.

BCC4465 Amantadine HCl Amantadine Hydrochloride is an antiviral and an antiparkinsonian drug.

BCC4462 Fenoldopam Fenoldopam(SKF 82526) is a drug and synthetic benzazepine derivative which acts as a selective D1 receptor partial agonist.

BCC7071 SKF 81297 hydrobromide

BCC7251 SKF 83959 hydrobromide

BCC6640 GBR 13069 dihydrochloride

BCC5130 Vanoxerine Vanoxerine (GBR-12909) is a competitive, potent, and highly selective dopamine reuptake inhibitor (Ki=1 nM). Vanoxerine (GBR-12909) binds to the target site on the dopamine transporter (DAT).

BCC6676 GBR 12783 dihydrochloride GBR 12783 dihydrochloride is a specific, potent and selective dopamine uptake inhibitor that inhibits the [3H]dopamine uptake by rat and mice striatal synaptosomes with IC50s of 1.8 nM and 1.2 nM, respectively. GBR 12783 dihydrochloride can improve memory performance and increase hippocampal acetylcholine release in rats.

BCC5129 Vanoxerine dihydrochloride Vanoxerine dihydrochloride (GBR-12909 dihydrochloride) is a competitive, potent, and highly selective dopamine reuptake inhibitor (Ki=1 nM). Vanoxerine dihydrochloride (GBR-12909 dihydrochloride) binds to the target site on the dopamine transporter (DAT).

BCC5380 GBR 12935 dihydrochloride GBR 12935 dihydrochloride is a potent, and selective dopamine reuptake inhibitor.

BCC7801 PG 01037 dihydrochloride

BCC4460 Chlorpromazine HCl Chlorpromazine Hydrochloride is an antagonist of the dopamine D2, 5HT2A, potassium channel and sodium channel. Chlorpromazine binds with D2 and 5HT2A with Kis of 363 nM and 8.3 nM, respectively.

BCC4459 Amisulpride Amisulpride is a dopamine D2/D3 receptor antagonist with Kis of 2.8 and 3.2 nM for human dopamine D2 and D3, respectively.

BCC6844 Remoxipride hydrochloride

BCC7252 SKF 83822 hydrobromide

BCC7165 Nemonapride

Products for Dopamine Receptor