GSK 789472 hydrochlorideD3 antagonist. Also D2 partial agonist CAS# 1257326-24-1 |
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Quality Control & MSDS
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| Cas No. | 1257326-24-1 | SDF | Download SDF |
| PubChem ID | 57347570 | Appearance | Powder |
| Formula | C15H22ClN3O | M.Wt | 295.81 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble to 100 mM in water and to 100 mM in DMSO | ||
| Chemical Name | 1-phenyl-3-(piperidin-2-ylmethyl)imidazolidin-2-one;hydrochloride | ||
| SMILES | C1CCNC(C1)CN2CCN(C2=O)C3=CC=CC=C3.Cl | ||
| Standard InChIKey | BYJUVPWUMBVSTK-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C15H21N3O.ClH/c19-15-17(12-13-6-4-5-9-16-13)10-11-18(15)14-7-2-1-3-8-14;/h1-3,7-8,13,16H,4-6,9-12H2;1H | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Selective dopamine D3 receptor antagonist and D2 partial agonist (pEC50 values are <5.5 and 8.3 respectively). Selective against the D4 receptor in both agonist and antagonist assays. Brain penetrant. |
GSK 789472 hydrochloride Dilution Calculator
GSK 789472 hydrochloride Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.3805 mL | 16.9027 mL | 33.8055 mL | 67.611 mL | 84.5137 mL |
| 5 mM | 0.6761 mL | 3.3805 mL | 6.7611 mL | 13.5222 mL | 16.9027 mL |
| 10 mM | 0.3381 mL | 1.6903 mL | 3.3805 mL | 6.7611 mL | 8.4514 mL |
| 50 mM | 0.0676 mL | 0.3381 mL | 0.6761 mL | 1.3522 mL | 1.6903 mL |
| 100 mM | 0.0338 mL | 0.169 mL | 0.3381 mL | 0.6761 mL | 0.8451 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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The identification of a selective dopamine D2 partial agonist, D3 antagonist displaying high levels of brain exposure.[Pubmed:20153647]
Bioorg Med Chem Lett. 2010 Mar 15;20(6):2013-6.
The identification of a highly selective D(2) partial agonist, D(3) antagonist tool molecule which demonstrates high levels of brain exposure and selectivity against an extensive range of dopamine, serotonin, adrenergic, histamine, and muscarinic receptors is described.
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