TC-E 5006γ-secretase modulator; reduces Aβ42 levels CAS# 1257395-14-4 |
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Quality Control & MSDS
3D structure
Package In Stock
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| Cas No. | 1257395-14-4 | SDF | Download SDF |
| PubChem ID | 68414868 | Appearance | Powder |
| Formula | C29H29F4NO2 | M.Wt | 499.54 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble to 100 mM in DMSO and to 100 mM in ethanol | ||
| Chemical Name | 2-[4-[(4-fluorophenyl)-(4-methylpiperidin-1-yl)methyl]-3-[4-(trifluoromethyl)phenyl]phenyl]propanoic acid | ||
| SMILES | CC1CCN(CC1)C(C2=CC=C(C=C2)F)C3=C(C=C(C=C3)C(C)C(=O)O)C4=CC=C(C=C4)C(F)(F)F | ||
| Standard InChIKey | ONYWALXTZFPKAS-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C29H29F4NO2/c1-18-13-15-34(16-14-18)27(21-5-10-24(30)11-6-21)25-12-7-22(19(2)28(35)36)17-26(25)20-3-8-23(9-4-20)29(31,32)33/h3-12,17-19,27H,13-16H2,1-2H3,(H,35,36) | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | γ-secretase modulator. Reduces Aβ42 levels in vitro (EC50 = 390 nM) and in vivo. Orally bioavailable. |
TC-E 5006 Dilution Calculator
TC-E 5006 Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.0018 mL | 10.0092 mL | 20.0184 mL | 40.0368 mL | 50.046 mL |
| 5 mM | 0.4004 mL | 2.0018 mL | 4.0037 mL | 8.0074 mL | 10.0092 mL |
| 10 mM | 0.2002 mL | 1.0009 mL | 2.0018 mL | 4.0037 mL | 5.0046 mL |
| 50 mM | 0.04 mL | 0.2002 mL | 0.4004 mL | 0.8007 mL | 1.0009 mL |
| 100 mM | 0.02 mL | 0.1001 mL | 0.2002 mL | 0.4004 mL | 0.5005 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Discovery of BIIB042, a Potent, Selective, and Orally Bioavailable gamma-Secretase Modulator.[Pubmed:24900267]
ACS Med Chem Lett. 2011 Aug 5;2(10):786-91.
We have investigated a novel series of acid-derived gamma-secretase modulators as a potential treatment of Alzheimer's disease. Optimization based on cellular potency and brain pharmacodynamics after oral dosing led to the discovery of 10a (BIIB042). Compound 10a is a potent gamma-secretase modulator, which lowered Abeta42, increased Abeta38, but had little to no effect on Abeta40 levels both in vitro and in vivo. In addition, compound 10a did not affect Notch signaling in our in vitro assessment. Compound 10a demonstrated excellent pharmacokinetic parameters in multiple species. Oral administration of 10a significantly reduced brain Abeta42 levels in CF-1 mice and Fischer rats, as well as plasma Abeta42 levels in cynomolgus monkeys. Compound 10a was selected as a candidate for preclinical safety evaluation.
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