Products for Gamma Secretase
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BCC1584
gamma-secretase modulator 2
gamma-secretase modulator 2 is a potent and selective γ-secretase modulator for treatment of Alzheimer's disease.
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BCC2104
BMS-708163 (Avagacestat)
Avagacestat (BMS-708163) is a potent inhibitor of γ-secretase, with IC50s of 0.27 nM and 0.30 nM for Aβ42 and Aβ40 inhibition; Avagacestat (BMS-708163) also inhibits NICD (Notch IntraCellular Domain) with IC50 of 0.84 nM and shows weak inhibition of CYP2C19, with IC50 of 20 μM.
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BCC1583
gamma-secretase modulator 1
γ-secretase inhibitior-1 is a gamma-secretase modulator, γ-secretase inhibitior-1 is useful for Alzheimer's disease.
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BCC2102
LY2811376
LY2811376 is the first orally available non-peptidic β-secretase (BACE1) inhibitor with IC50 of 239 nM-249 nM, that acts to decrease Aβ secretion with EC50 of 300 nM, and demonstrates to have 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition over other aspartic proteases including cathepsin D, pepsin, or renin.
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BCC7981
TC-E 5006
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BCC2105
LY3039478
Crenigacestat is an orally active Notch and γ-secretase inhibitor, with an IC50 of ∼1nM in most of the tumor cell lines tested.
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BCC1585
gamma-secretase modulator 3
gamma-secretase modulator 3 is a gamma-secretase modulator.
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BCC2341
Compound W
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BCC2100
YO-01027 (Dibenzazepine, DBZ)
YO-01027 (Dibenzazepine;DBZ) is a potent γ-secretase inhibitor with IC50 values of 2.92 and 2.64 nM for Notch and APPL cleavage, respectively.
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BCC2101
LY-411575
LY-411575 is a potent γ-secretase inhibitor with IC50 of 0.078 nM/0.082 nM (membrane/cell-based), and also inhibits Notch S3 cleavage with IC50 of 0.39 nM.
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BCC5443
LY-411575 isomer 1
LY-411575 isomer 1 is an isomer of LY411575, which is a potent γ-secretase inhibitor.
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BCC2103
LY-900009
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BCC2340
BMS 299897
BMS 299897 is a sulfonamide γ-secretase inhibitor with an IC50 of 7 nM for Aβ production inhibition in HEK293 cells stably overexpressing amyloid precursor protein (APP).
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BCC2344
L-685,458
L-685458 is a potent inhibitor of Amyloid β-Protein precursor γ-secretase activity with IC50 of 17 nM, shows greater than 50-100-fold selectivity over other aspartyl proteases tested.
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BCC2090
MK-0752
MK-0752 is a moderately potent γ-secretase inhibitor, which reduces Aβ40 production with IC50 of 5 nM.
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BCC2342
Flurizan
Tarenflurbil ((R)-Flurbiprofen) is the R-enantiomer of the racemate NSAID Flurbiprofen, Tarenflurbil ((R)-Flurbiprofen) inhibits the binding of [3H]9-cis-RA to RXRα LBD with IC50 of 75 μM.
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BCC2343
JLK 6
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BCC2345
MRK 560
MRK-560 is a potent, orally bioavailable and brain-penetrant γ-secretase inhibitor.
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BCC2346
Begacestat
Begacestat (GSI-953) is a selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase (IC50Aβ40=15 nM) for the treatment of Alzheimer's disease.
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BCC2089
RO4929097
RO4929097 (RG-4733) is a γ secretase inhibitor with IC50 of 4 nM, inhibiting cellular processing of Aβ40 and Notch with EC50 of 14 nM and 5 nM, respectively.
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BCC1848
PF-03084014
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BCC1540
E 2012
E 2012 is a potent gamma (γ) secretase modulator without affecting Notch processing. E 2012 inhibits 3β-hydroxysterol Δ24-reductase (DHCR24) at the final step in the cholesterol biosynthesis. E 2012 aims at Alzheimer's disease by reduction of amyloid β-42, and induces cataract following repeated doses in the rat.
