Gamma Secretase
Gamma secretase (γ-secretase), a member of the intramembrane cleaving protease (i-CLiP) family, is a promiscuous di-aspartyl protease that catalyzes the regulated intramembrane proteolysis (RIP), in which substrate proteins are cleaved within their membrane-spanning domain. A functional γ-secretase is a multi-protein complex consisting of the catalytic component, presenilin (PSEN), and three protein cofactors, including nicastrin (NCT), anterior-pharynx defective-1 (APH1) and PSEN enhancer-2 (PEN2). So far, 90 substrates of γ-secretase have been identified, which are type-I transmembrane proteins, except for glutamate receptor GluR3, polycystin-1 and glucosaminyltransferase (GnT-V), and appear to function as signaling proteins regulating a wide variety of cellular events, such as Notch signaling pathway.
Products for Gamma Secretase
- Cat.No. Product Name Information
- BCC1540 E 2012γ--Secretase modulator
- BCC1583 gamma-secretase modulator 1Useful for Alzheimer's disease.
- BCC1584 gamma-secretase modulator 2Attenuate Aβ production in Alzheimer's Disease
- BCC1585 gamma-secretase modulator 3Modulator of gamma-secretase
- BCC1848 PF-03084014γ-secretase inhibitor
- BCC2089 RO4929097γ secretase inhibitor
- BCC2090 MK-0752γ-secretase inhibitor
- BCC2100 YO-01027 (Dibenzazepine, DBZ)γ-secretase inhibitor
- BCC2101 LY-411575Gamma secretase inhibitor
- BCC2102 LY2811376Non-peptidic BACE1 inhibitor
- BCC2103 LY-900009Potent Notch inhibitor
- BCC2104 BMS-708163 (Avagacestat)γ-secretase inhibitor
- BCC2105 LY3039478Notch inhibitor, novel and potent
- BCC2340 BMS 299897γ--secretase inhibitor, potent and orally active
- BCC2341 Compound Wγ-secretase inhibitor
- BCC2342 FlurizanNSAID,inhibits γ-secretase activity
- BCC2343 JLK 6γ-secretase inhibitor
- BCC2344 L-685,458γ-secretase inhibitor
- BCC2345 MRK 560γ-secretase inhibitor
- BCC2346 Begacestatγ-secretase inhibitor
- BCC5443 LY-411575 isomer 1
- BCC7981 TC-E 5006γ-secretase modulator; reduces Aβ42 levels