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9-Hydroxycalabaxanthone hydrate

CAS# 483-14-7

9-Hydroxycalabaxanthone hydrate

2D Structure

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9-Hydroxycalabaxanthone hydrate

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Chemical Properties of 9-Hydroxycalabaxanthone hydrate

Cas No. 483-14-7 SDF Download SDF
PubChem ID 56840489 Appearance Yellow powder
Formula C24H26O7 M.Wt 426.5
Type of Compound Xanthones Storage Desiccate at -20°C
Synonyms 9-Hydroxycalabaxathoe hydrate
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 5,9-dihydroxy-7-(3-hydroxy-3-methylbutyl)-8-methoxy-2,2-dimethylpyrano[3,2-b]xanthen-6-one
SMILES CC1(C=CC2=C(O1)C=C3C(=C2O)C(=O)C4=C(C(=C(C=C4O3)O)OC)CCC(C)(C)O)C
Standard InChIKey BCHPGRIFQLDQCK-UHFFFAOYSA-N
Standard InChI InChI=1S/C24H26O7/c1-23(2,28)8-6-13-18-16(10-14(25)22(13)29-5)30-17-11-15-12(7-9-24(3,4)31-15)20(26)19(17)21(18)27/h7,9-11,25-26,28H,6,8H2,1-5H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 9-Hydroxycalabaxanthone hydrate

The fruits of Garcinia mangostana

Biological Activity of 9-Hydroxycalabaxanthone hydrate

DescriptionThe combination of 9-hydroxycalabaxanthone with α-mangostin showed the synergistic antimalarial interaction in both clones.
In vitro

The in vitro antimalarial interaction of 9-hydroxycalabaxanthone and α-mangostin with mefloquine/artesunate.[Reference: WebLink]

Acta Parasitologica, 2014, 60(1).

Multidrug resistance Plasmodium falciparum is the major health problem in Thailand. Discovery and development of new antimalarial drugs with novel modes of action is urgently required.
METHODS AND RESULTS:
The aim of the present study was to investigate the antimalarial interaction of 9-hydroxycalabaxanthone and α-mangostin with the standard antimalarial drugs mefloquine and artesunate in chloroquine sensitive (3D7) and chloroquine resistant (K1) P. falciparum clones in vitro. Median (range) IC50 (drug concentration which produces 50% parasite growth inhibition) values of the 9-hydroxycalabaxanthone, α-mangostin, artesunate and mefloquine for 3D7 vs K1 clones were 1.5 (0.9-2.1) vs 1.2 (1.1-1.6) μM, 17.9 (15.7.0-20.0) vs 9.7 (6.0-14.0) μM, 1.0 (0.4-3.0) vs 1.7 (1.0-2.5) nM, and 13.3 (11.1-13.3) vs 7.1 (6.7-12.2) nM, respectively. Analysis of isobologram and combination index (CI) of 9-hydroxycalabaxanthone with artesunate or mefloquine showed synergistic and indifference antimalarial interaction, respectively. α-mangostin-artesunate combination exhibited a slight antagonistic effect of antimalarial interaction, whereas α-mangostin and mefloquine combination showed indifference interaction in both clones.
CONCLUSIONS:
The combination of 9-hydroxycalabaxanthone with α-mangostin showed the synergistic antimalarial interaction in both clones.

9-Hydroxycalabaxanthone hydrate Dilution Calculator

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9-Hydroxycalabaxanthone hydrate Molarity Calculator

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Preparing Stock Solutions of 9-Hydroxycalabaxanthone hydrate

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.3447 mL 11.7233 mL 23.4467 mL 46.8933 mL 58.6166 mL
5 mM 0.4689 mL 2.3447 mL 4.6893 mL 9.3787 mL 11.7233 mL
10 mM 0.2345 mL 1.1723 mL 2.3447 mL 4.6893 mL 5.8617 mL
50 mM 0.0469 mL 0.2345 mL 0.4689 mL 0.9379 mL 1.1723 mL
100 mM 0.0234 mL 0.1172 mL 0.2345 mL 0.4689 mL 0.5862 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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