Dalbergin

CAS# 482-83-7

Dalbergin

Catalog No. BCN7452----Order now to get a substantial discount!

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Quality Control of Dalbergin

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Chemical structure

Dalbergin

3D structure

Chemical Properties of Dalbergin

Cas No. 482-83-7 SDF Download SDF
PubChem ID 442768 Appearance Powder
Formula C16H12O4 M.Wt 268.26
Type of Compound Coumarins Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 6-hydroxy-7-methoxy-4-phenylchromen-2-one
SMILES COC1=C(C=C2C(=CC(=O)OC2=C1)C3=CC=CC=C3)O
Standard InChIKey AZELSOYQOIUPBZ-UHFFFAOYSA-N
Standard InChI InChI=1S/C16H12O4/c1-19-15-9-14-12(7-13(15)17)11(8-16(18)20-14)10-5-3-2-4-6-10/h2-9,17H,1H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Dalbergin

The heartwood of Dalbergia sissoo.

Biological Activity of Dalbergin

Description1. Dalbergin exhibits similar bone conserving effect against bone-loss as estradiol treatment, it as a therapeutic candidate against postmenopausal osteoporosis. 2. Dalbergin prevents some effects of photoaging and maintain skin integrity by regulating the degradation of the extracellular matrix proteins.
TargetsNrf2 | NF-kB

Dalbergin Dilution Calculator

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Dalbergin Molarity Calculator

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Preparing Stock Solutions of Dalbergin

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.7277 mL 18.6386 mL 37.2773 mL 74.5545 mL 93.1932 mL
5 mM 0.7455 mL 3.7277 mL 7.4555 mL 14.9109 mL 18.6386 mL
10 mM 0.3728 mL 1.8639 mL 3.7277 mL 7.4555 mL 9.3193 mL
50 mM 0.0746 mL 0.3728 mL 0.7455 mL 1.4911 mL 1.8639 mL
100 mM 0.0373 mL 0.1864 mL 0.3728 mL 0.7455 mL 0.9319 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Dalbergin

Dalbergia odorifera Extract Ameliorates UVB-Induced Wrinkle Formation by Modulating Expression of Extracellular Matrix Proteins.[Pubmed:25620496]

Drug Dev Res. 2015 Feb;76(1):48-56.

Preclinical Research Emerging evidence suggests that Dalbergia odorifera T. Chen (Leguminosae), an indigenous medicinal herb, has therapeutic potential. This study examined the antiwrinkle effects of ethanol extracts of D. odorifera in UVB-irradiated human skin cells. Ethanol extracts of D. odorifera and thier constituents, Dalbergin and sativanone, induced expression of collagen type I and transforming growth factor (TGF)-beta1 in human dermal fibroblasts. In HR-1 hairless mice exposed to UVB, the ethanol extract reduced wrinkle formation and skin thickness. This inhibitory effect of ethanol extract was associated with the restoration of collagen type I, TGF-beta1, and elastin to levels approaching those in skin tissues not exposed to UVB, which was accompanied by the reduction of matrix metalloproteinase-2 and upregulation of tissue inhibitors of metalloproteinase (TIMP)-2 and TIMP-3 in skin tissue exposed to UVB. These results suggest that the ethanol extracts prevent some effects of photoaging and maintain skin integrity by regulating the degradation of the extracellular matrix proteins. (c) 2015 Wiley Periodicals, Inc.

Fast and long acting neoflavonoids dalbergin isolated from Dalbergia sissoo heartwood is osteoprotective in ovariectomized model of osteoporosis: Osteoprotective effect of Dalbergin.[Pubmed:27522257]

Biomed Pharmacother. 2016 Oct;83:942-957.

OBJECTIVE: This study aims to evaluate the skeletal effects of Dalbergin (DBN), isolated from Dalbergia sissoo heartwood, in ovariectomized (OVx) BALB/c mice, a postmenopausal osteoporosis model of bone loss. METHODS: Adult BALB/c mice were used and randomly assigned in to six groups with 6 animals (n=6) in each group: sham (surgery operated without ovariectomy) with vehicle, ovariectomy with vehicle, ovariectomy (OVx) with estradiol (E2 5.0mugkg(-)1day(-1)), or ovariectomy with Dalbergin at three different doses of DBN (1.0, 5.0 and10mgkg(-1)day(-1)). Daily oral administration of the vehicle, estradiol, or DBN was started 8 weeks post-surgery and continued for 8 weeks. At the end of experiment, mice were sacrificed and assessed for trabecular bone structure of tibia, lumbar vertebra (L5) and alterations in biochemical and uterine parameters, pharmacokinetic profile and gene expression were monitored for each group. RESULTS: Treatment with DBN prevented trabecular bone loss in cancellous bone in the tibial metaphysis and lumbar vertebra region of the ovariectomized mice. Micro-CT data showed that mice treated with DBN at 1.0mgkg(-1)day(-1) exhibited improved bone micro-architecture that was sustained with decreased expression of bone resorption markers like TRAP and RANK and caused an increase in osteogenic markers like RUNX2, BMP2 and OPG/RANKL ratio compared with OVx+vehicle treated mice. Moreover, DBN treatment induced no uterine estrogenicity and significantly lowered the osteocalcin amount in serum when compared with OVx+V group. DBN reached its maximum concentration (Cmax) 238.49+/-21.37ngml(-1) in serum as early as 1h of administration. Overall, DBN (1.0mgkg(-1)day(-1)) treatment exhibited similar bone conserving effect against bone-loss as estradiol treatment. CONCLUSION: Daily oral administration of DBN for 8 weeks showed significant anabolic effects on bone micro-architectural parameters along with down regulation of bone resorptive markers without compromising safety at uterine level. Therefore, our study provides basis for DBN as a therapeutic candidate against postmenopausal osteoporosis.

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