Cheilanthifoline

CAS# 483-44-3

Cheilanthifoline

Catalog No. BCN7827----Order now to get a substantial discount!

Product Name & Size Price Stock
Cheilanthifoline: 5mg $322 In Stock
Cheilanthifoline: 10mg Please Inquire In Stock
Cheilanthifoline: 20mg Please Inquire Please Inquire
Cheilanthifoline: 50mg Please Inquire Please Inquire
Cheilanthifoline: 100mg Please Inquire Please Inquire
Cheilanthifoline: 200mg Please Inquire Please Inquire
Cheilanthifoline: 500mg Please Inquire Please Inquire
Cheilanthifoline: 1000mg Please Inquire Please Inquire

Quality Control of Cheilanthifoline

Number of papers citing our products

Chemical structure

Cheilanthifoline

3D structure

Chemical Properties of Cheilanthifoline

Cas No. 483-44-3 SDF Download SDF
PubChem ID 440582 Appearance Powder
Formula C19H19NO4 M.Wt 325.36
Type of Compound Miscellaneous Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES COC1=C(C=C2C3CC4=C(CN3CCC2=C1)C5=C(C=C4)OCO5)O
Standard InChIKey FVXCQULKSPVRPK-HNNXBMFYSA-N
Standard InChI InChI=1S/C19H19NO4/c1-22-18-7-12-4-5-20-9-14-11(2-3-17-19(14)24-10-23-17)6-15(20)13(12)8-16(18)21/h2-3,7-8,15,21H,4-6,9-10H2,1H3/t15-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Cheilanthifoline

The rhizomes of Sinomenium acutum.

Biological Activity of Cheilanthifoline

Description1. Cheilanthifoline has anti-osteoclastogenic property, it gives significant inhibitions on receptor activator of nuclear factor-κB ligand-induced differentiation of mouse bone marrow-derived macrophages into multinucleated osteoclasts. 2. Cheilanthifoline shows promising in vitro antiplasmodial activities against Plasmodium falciparum.
TargetsNF-kB | Antifection

Cheilanthifoline Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

Cheilanthifoline Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of Cheilanthifoline

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.0735 mL 15.3676 mL 30.7352 mL 61.4704 mL 76.838 mL
5 mM 0.6147 mL 3.0735 mL 6.147 mL 12.2941 mL 15.3676 mL
10 mM 0.3074 mL 1.5368 mL 3.0735 mL 6.147 mL 7.6838 mL
50 mM 0.0615 mL 0.3074 mL 0.6147 mL 1.2294 mL 1.5368 mL
100 mM 0.0307 mL 0.1537 mL 0.3074 mL 0.6147 mL 0.7684 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University
Featured Products
New Products
 

References on Cheilanthifoline

Antiplasmodial agents from the Bhutanese medicinal plant Corydalis calliantha.[Pubmed:19496064]

Phytother Res. 2010 Apr;24(4):481-5.

The alkaloidal components of the Bhutanese medicinal plant Corydalis calliantha Long, which is used for the treatment of malaria, have been assessed. Four known alkaloids, protopine (1), scoulerine (2), Cheilanthifoline (3) and stylopine (4) are reported from this plant for the first time. The protopine alkaloid, protopine, and the tetrahydroprotoberine alkaloid, Cheilanthifoline, showed promising in vitro antiplasmodial activities against Plasmodium falciparum, both wild type (TM4) and multidrug resistant (K1) strains with IC(50) values in the range of 2.78-4.29 microM. Such activity had not been demonstrated previously for Cheilanthifoline. The results thus support, at a molecular level, the clinical use of this plant in the Bhutanese traditional medicine and identified Cheilanthifoline as a potential new antimalarial drug lead.

Anti-osteoclastogenic effects of isoquinoline alkaloids from the rhizome extract of Sinomenium acutum.[Pubmed:26992921]

Arch Pharm Res. 2016 May;39(5):713-20.

A phytochemical investigation for the rhizome extract from Sinomenium acutum (Menispermaceae) resulted in the isolation of several active principles responsible for the anti-osteoclastogenic property of the extract, together with related isoquinoline alkaloids (1-13) including two new compounds, 1 and 2. Among isolated compounds, salutaridine (7), dauricumine (10), Cheilanthifoline (12), and dauriporphine (13) were observed to give significant inhibitions on receptor activator of nuclear factor-kappaB ligand-induced differentiation of mouse bone marrow-derived macrophages into multinucleated osteoclasts, respectively. The chemical structures of two newly isolated compounds, 1 and 2 were established as 8-demethoxycephatonine (1) and 7(R)-7,8-dihydrosinomenine (2), by spectroscopic analyses including 2D NMR experiments.

Keywords:

Cheilanthifoline,483-44-3,Natural Products, buy Cheilanthifoline , Cheilanthifoline supplier , purchase Cheilanthifoline , Cheilanthifoline cost , Cheilanthifoline manufacturer , order Cheilanthifoline , high purity Cheilanthifoline

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: