IsorauhimbineCAS# 483-09-0 |
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Quality Control & MSDS
3D structure
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| Cas No. | 483-09-0 | SDF | Download SDF |
| PubChem ID | 6452110 | Appearance | Powder |
| Formula | C21H26N2O3 | M.Wt | 354.5 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | methyl (1R,15S,18S,19S,20S)-18-hydroxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate | ||
| SMILES | COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O | ||
| Standard InChIKey | BLGXFZZNTVWLAY-RIEHRDFOSA-N | ||
| Standard InChI | InChI=1S/C21H26N2O3/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24/h2-5,12,15,17-19,22,24H,6-11H2,1H3/t12-,15+,17-,18+,19+/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1.3-Epi-alpha-yohimbine(Isorauhimbine) has alpha adrenoceptor blocking activities, has cardiovascular effects. |
| Targets | Adrenergic Receptor |
Isorauhimbine Dilution Calculator
Isorauhimbine Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.8209 mL | 14.1044 mL | 28.2087 mL | 56.4175 mL | 70.5219 mL |
| 5 mM | 0.5642 mL | 2.8209 mL | 5.6417 mL | 11.2835 mL | 14.1044 mL |
| 10 mM | 0.2821 mL | 1.4104 mL | 2.8209 mL | 5.6417 mL | 7.0522 mL |
| 50 mM | 0.0564 mL | 0.2821 mL | 0.5642 mL | 1.1283 mL | 1.4104 mL |
| 100 mM | 0.0282 mL | 0.141 mL | 0.2821 mL | 0.5642 mL | 0.7052 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Yohimbine diastereoisomers: cardiovascular effects after central and peripheral application in the rat.[Pubmed:7219571]
Naunyn Schmiedebergs Arch Pharmacol. 1981 Jan;315(3):227-31.
The cardiovascular effects of four yohimbine diastereoisomers, yohimbine, rauwolscine, corynanthine, and 3-epi-alpha-yohimbine, were compared in urethane-anaesthetized and conscious, normotensive Sprague-Dawley rats. Intravenous cumulative infusions (10--500 microgram) of the drugs to anaesthetized rats decreased blood pressure and blunted the pressor response to intravenous adrenaline injections. Corynanthine was the most potent isomer in this regard, followed by yohimbine, rauwolscine, and 3-epi-alpha-yohimbine. Depressor responses following intravenous bolus doses (40 microgram) showed a similar ranking. Intraventricular injections of yohimbine to anaesthetized rats decreased blood pressure dose-dependently, as did injections of corynanthine and rauwolscine. Responses indicated the ranking to be yohimbine greater or equal to rauwolscine greater than corynanthine for this effect at the 40 microgram dose. Heart rate was also decreased by these isomers, but not in a dose-dependent fashion. In conscious rats, the intraventricular injection of these isomers (20 microgram) increased blood pressure and heart rate. No differences were noted in terms of blood pressure responses; but, in causing tachycardia, the ranking was rauwolscine greater than yohimbine greater than corynanthine. These data suggest that after intraventricular application in anaesthetized rats, the effects of these alpha-adrenoceptor blockers are related to their individual affinity for the alpha 2 adrenoceptor.
