CephaelineCAS# 483-17-0 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
Cas No. | 483-17-0 | SDF | Download SDF |
PubChem ID | 442195 | Appearance | Powder |
Formula | C28H38N2O4 | M.Wt | 466.6 |
Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
Chemical Name | (1R)-1-[[(2S,3R,11bS)-3-ethyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizin-2-yl]methyl]-7-methoxy-1,2,3,4-tetrahydroisoquinolin-6-ol | ||
SMILES | CCC1CN2CCC3=CC(=C(C=C3C2CC1CC4C5=CC(=C(C=C5CCN4)O)OC)OC)OC | ||
Standard InChIKey | DTGZHCFJNDAHEN-OZEXIGSWSA-N | ||
Standard InChI | InChI=1S/C28H38N2O4/c1-5-17-16-30-9-7-19-13-27(33-3)28(34-4)15-22(19)24(30)11-20(17)10-23-21-14-26(32-2)25(31)12-18(21)6-8-29-23/h12-15,17,20,23-24,29,31H,5-11,16H2,1-4H3/t17-,20-,23+,24-/m0/s1 | ||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. |
Description | Cephaeline was highly active against protected primary CLL cells (relative IC50's 35 nM ) and acted by repressing HIF-1α and disturbing intracellular redox homeostasis. |
Targets | HIF-1 |
In vitro | Oxidative stress as candidate therapeutic target to overcome microenvironmental protection of CLL.[Pubmed: 31300746]Leukemia. 2019 Jul 12.Chronic lymphocytic leukemia (CLL) cells depend on microenvironmental non-malignant cells for survival.
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Structure Identification | J Nat Prod. 2000 May;63(5):723-5.Two Alangium alkaloids from Alangium lamarckii.[Pubmed: 10843602 ]
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Cephaeline Dilution Calculator
Cephaeline Molarity Calculator
1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
1 mM | 2.1432 mL | 10.7158 mL | 21.4316 mL | 42.8633 mL | 53.5791 mL |
5 mM | 0.4286 mL | 2.1432 mL | 4.2863 mL | 8.5727 mL | 10.7158 mL |
10 mM | 0.2143 mL | 1.0716 mL | 2.1432 mL | 4.2863 mL | 5.3579 mL |
50 mM | 0.0429 mL | 0.2143 mL | 0.4286 mL | 0.8573 mL | 1.0716 mL |
100 mM | 0.0214 mL | 0.1072 mL | 0.2143 mL | 0.4286 mL | 0.5358 mL |
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. |
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Emetine inhibits Zika and Ebola virus infections through two molecular mechanisms: inhibiting viral replication and decreasing viral entry.[Pubmed:29872540]
Cell Discov. 2018 Jun 5;4:31.
The re-emergence of Zika virus (ZIKV) and Ebola virus (EBOV) poses serious and continued threats to the global public health. Effective therapeutics for these maladies is an unmet need. Here, we show that emetine, an anti-protozoal agent, potently inhibits ZIKV and EBOV infection with a low nanomolar half maximal inhibitory concentration (IC50) in vitro and potent activity in vivo. Two mechanisms of action for emetine are identified: the inhibition of ZIKV NS5 polymerase activity and disruption of lysosomal function. Emetine also inhibits EBOV entry. Cephaeline, a desmethyl analog of emetine, which may be better tolerated in patients than emetine, exhibits a similar efficacy against both ZIKV and EBOV infections. Hence, emetine and Cephaeline offer pharmaceutical therapies against both ZIKV and EBOV infection.