Parvifuran

CAS# 69470-93-5

Parvifuran

Catalog No. BCN7780----Order now to get a substantial discount!

Product Name & Size Price Stock
Parvifuran: 5mg $989 In Stock
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Quality Control of Parvifuran

Number of papers citing our products

Chemical structure

Parvifuran

3D structure

Chemical Properties of Parvifuran

Cas No. 69470-93-5 SDF Download SDF
PubChem ID 5314863 Appearance Powder
Formula C16H14O3 M.Wt 254.28
Type of Compound Phenols Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 6-methoxy-3-methyl-2-phenyl-1-benzofuran-5-ol
SMILES CC1=C(OC2=CC(=C(C=C12)O)OC)C3=CC=CC=C3
Standard InChIKey RICORHDCMSYMOL-UHFFFAOYSA-N
Standard InChI InChI=1S/C16H14O3/c1-10-12-8-13(17)15(18-2)9-14(12)19-16(10)11-6-4-3-5-7-11/h3-9,17H,1-2H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Parvifuran

The heartwood of Dalbergia parviflora.

Biological Activity of Parvifuran

DescriptionParvifuran is a natural product from Dalbergia parviflora.

Protocol of Parvifuran

Structure Identification
Phytochemistry, 1981, 20(2):291-293.

Arylbenzofurans from Dalbergia parviflora.[Reference: WebLink]


METHODS AND RESULTS:
The isolation of two polysubstituted arylbenzofurans from the heartwood of Dalbergia parviflora is described. Their structures were elucidated mainly by spectroscopic techniques (UV, IR, 1H and 13C NMR).
CONCLUSIONS:
They were named Parvifuran (5-hydroxy-6-methoxy-3-methyl-2-phenylbenzofuran) and isoParvifuran (5-hydroxy-6-methoxy-2-methyl-3-phenylbenzofuran) and are the first compounds of this class isolated from a Dalbergia species.

Parvifuran Dilution Calculator

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Parvifuran Molarity Calculator

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Preparing Stock Solutions of Parvifuran

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.9327 mL 19.6634 mL 39.3267 mL 78.6535 mL 98.3168 mL
5 mM 0.7865 mL 3.9327 mL 7.8653 mL 15.7307 mL 19.6634 mL
10 mM 0.3933 mL 1.9663 mL 3.9327 mL 7.8653 mL 9.8317 mL
50 mM 0.0787 mL 0.3933 mL 0.7865 mL 1.5731 mL 1.9663 mL
100 mM 0.0393 mL 0.1966 mL 0.3933 mL 0.7865 mL 0.9832 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Parvifuran

4-parvifuran inhibits metastatic and invasive actions through the JAK2/STAT3 pathway in osteosarcoma cells.[Pubmed:28386742]

Arch Pharm Res. 2017 May;40(5):601-609.

This study was performed to examine the anticancer and anti-metastatic effects of 4-Parvifuran (PVN), a novel flavonoid isolated from the heartwood of Dalbergia odorifera, and to study its underlying signaling pathway in human osteosarcoma cells. In the present study, PVN was found to inhibit cell proliferation in a concentration- and time-dependent manner in the human osteosarcoma cell lines studied (MG-63 and U-2 OS) and induce apoptosis, as evidenced by Annexin V(+) and TUNEL(+) cells. Cleaved poly (ADP-ribose) polymerase (PARP) and caspase-3 were up-regulated while anti-apoptotic proteins including Bcl-2, Bcl-xL, and survivin were down-regulated after treatment with PVN. Matrigel cell migration assay, invasion assay, and soft agar assay were used to show that PVN effectively suppressed cell migration and invasion and colony formation in osteosarcoma cells. Protein and mRNA levels of MMP-2 and MMP-9 were reduced by PVN in a concentration-dependent manner. Furthermore, PVN inhibited Janus kinase 2 (JAK2)/signal transducers and activators of transcription 3 (STAT3), mitogen-activated protein kinases (MAPKs) including JNK, ERK, p38 kinase, and cAMP response element-binding protein (CREB). Therefore, this is the first study to demonstrate that PVN might be a novel anticancer and anti-metastatic agent for the treatment of osteosarcoma through the inhibition of JAK2/STAT3, MAPKs, and CREB signaling pathways.

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