ParvifuranCAS# 69470-93-5 |
Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 69470-93-5 | SDF | Download SDF |
| PubChem ID | 5314863 | Appearance | Powder |
| Formula | C16H14O3 | M.Wt | 254.28 |
| Type of Compound | Phenols | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 6-methoxy-3-methyl-2-phenyl-1-benzofuran-5-ol | ||
| SMILES | CC1=C(OC2=CC(=C(C=C12)O)OC)C3=CC=CC=C3 | ||
| Standard InChIKey | RICORHDCMSYMOL-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C16H14O3/c1-10-12-8-13(17)15(18-2)9-14(12)19-16(10)11-6-4-3-5-7-11/h3-9,17H,1-2H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Parvifuran is a natural product from Dalbergia parviflora. |
| Structure Identification | Phytochemistry, 1981, 20(2):291-293.Arylbenzofurans from Dalbergia parviflora.[Reference: WebLink]
|
Parvifuran Dilution Calculator
Parvifuran Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.9327 mL | 19.6634 mL | 39.3267 mL | 78.6535 mL | 98.3168 mL |
| 5 mM | 0.7865 mL | 3.9327 mL | 7.8653 mL | 15.7307 mL | 19.6634 mL |
| 10 mM | 0.3933 mL | 1.9663 mL | 3.9327 mL | 7.8653 mL | 9.8317 mL |
| 50 mM | 0.0787 mL | 0.3933 mL | 0.7865 mL | 1.5731 mL | 1.9663 mL |
| 100 mM | 0.0393 mL | 0.1966 mL | 0.3933 mL | 0.7865 mL | 0.9832 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- 17-PA
Catalog No.:BCC7452
CAS No.:694438-95-4
- SB505124
Catalog No.:BCC5087
CAS No.:694433-59-5
- Amonafide
Catalog No.:BCC1249
CAS No.:69408-81-7
- Lappaol H
Catalog No.:BCN8415
CAS No.:69394-18-9
- Sulbactam sodium
Catalog No.:BCC4852
CAS No.:69388-84-7
- Schisanhenol
Catalog No.:BCN2508
CAS No.:69363-14-0
- Pendulone
Catalog No.:BCN8248
CAS No.:69359-09-7
- Boc-D-Thr(Bzl)-OH
Catalog No.:BCC3454
CAS No.:69355-99-3
- Galanthamine hydrochloride
Catalog No.:BCC8277
CAS No.:5072-47-9
- Obtucarbamate A
Catalog No.:BCN3936
CAS No.:6935-99-5
- 2-Benzylaminopyridine
Catalog No.:BCC8565
CAS No.:6935-27-9
- CPPHA
Catalog No.:BCC1501
CAS No.:693288-97-0
- 2-Methyl-4-isobutyrylphloroglucinol
Catalog No.:BCN7176
CAS No.:69480-03-1
- Boc-D-His(Tos)-OH
Catalog No.:BCC3405
CAS No.:69541-68-0
- Thymopentin
Catalog No.:BCN8347
CAS No.:69558-55-0
- Octadecyl caffeate
Catalog No.:BCN6609
CAS No.:69573-60-0
- Tupichilignan A
Catalog No.:BCN4257
CAS No.:69586-96-5
- 4-Hydroxybenzylamine
Catalog No.:BCN1805
CAS No.:696-60-6
- CRT0044876
Catalog No.:BCC5109
CAS No.:6960-45-8
- Chamaejasmine
Catalog No.:BCN3132
CAS No.:69618-96-8
- H-D-Asp(OMe)-OMe.HCl
Catalog No.:BCC2897
CAS No.:69630-50-8
- H-D-Met-OMe.HCl
Catalog No.:BCC2998
CAS No.:69630-60-0
- Pd-C-II
Catalog No.:BCN4599
CAS No.:
- NSC 66811
Catalog No.:BCC2255
CAS No.:6964-62-1
4-parvifuran inhibits metastatic and invasive actions through the JAK2/STAT3 pathway in osteosarcoma cells.[Pubmed:28386742]
Arch Pharm Res. 2017 May;40(5):601-609.
This study was performed to examine the anticancer and anti-metastatic effects of 4-Parvifuran (PVN), a novel flavonoid isolated from the heartwood of Dalbergia odorifera, and to study its underlying signaling pathway in human osteosarcoma cells. In the present study, PVN was found to inhibit cell proliferation in a concentration- and time-dependent manner in the human osteosarcoma cell lines studied (MG-63 and U-2 OS) and induce apoptosis, as evidenced by Annexin V(+) and TUNEL(+) cells. Cleaved poly (ADP-ribose) polymerase (PARP) and caspase-3 were up-regulated while anti-apoptotic proteins including Bcl-2, Bcl-xL, and survivin were down-regulated after treatment with PVN. Matrigel cell migration assay, invasion assay, and soft agar assay were used to show that PVN effectively suppressed cell migration and invasion and colony formation in osteosarcoma cells. Protein and mRNA levels of MMP-2 and MMP-9 were reduced by PVN in a concentration-dependent manner. Furthermore, PVN inhibited Janus kinase 2 (JAK2)/signal transducers and activators of transcription 3 (STAT3), mitogen-activated protein kinases (MAPKs) including JNK, ERK, p38 kinase, and cAMP response element-binding protein (CREB). Therefore, this is the first study to demonstrate that PVN might be a novel anticancer and anti-metastatic agent for the treatment of osteosarcoma through the inhibition of JAK2/STAT3, MAPKs, and CREB signaling pathways.
