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Obtucarbamate A

CAS# 6935-99-5

Obtucarbamate A

Catalog No. BCN3936----Order now to get a substantial discount!

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Obtucarbamate A: 5mg $615 In Stock
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Quality Control of Obtucarbamate A

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Chemical structure

Obtucarbamate A

3D structure

Chemical Properties of Obtucarbamate A

Cas No. 6935-99-5 SDF Download SDF
PubChem ID 235307 Appearance Powder
Formula C11H14N2O4 M.Wt 238.2
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name methyl N-[3-(methoxycarbonylamino)-4-methylphenyl]carbamate
SMILES CC1=C(C=C(C=C1)NC(=O)OC)NC(=O)OC
Standard InChIKey CNPWIVIIZHULCN-UHFFFAOYSA-N
Standard InChI InChI=1S/C11H14N2O4/c1-7-4-5-8(12-10(14)16-2)6-9(7)13-11(15)17-3/h4-6H,1-3H3,(H,12,14)(H,13,15)
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Obtucarbamate A

The herbs of Dracaena sanderiana

Biological Activity of Obtucarbamate A

Description1. Obtucarbamate A has antitussive activity. 2. Obtucarbamate A exhibits significant inhibitory effect against neuroinflammation with the IC50 value of 10.57 uM .
TargetsNO

Obtucarbamate A Dilution Calculator

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Obtucarbamate A Molarity Calculator

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Preparing Stock Solutions of Obtucarbamate A

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.1982 mL 20.9908 mL 41.9815 mL 83.9631 mL 104.9538 mL
5 mM 0.8396 mL 4.1982 mL 8.3963 mL 16.7926 mL 20.9908 mL
10 mM 0.4198 mL 2.0991 mL 4.1982 mL 8.3963 mL 10.4954 mL
50 mM 0.084 mL 0.4198 mL 0.8396 mL 1.6793 mL 2.0991 mL
100 mM 0.042 mL 0.2099 mL 0.4198 mL 0.8396 mL 1.0495 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Obtucarbamate A

[Antitussive constituents of Disporum cantoniense].[Pubmed:24791497]

Zhongguo Zhong Yao Za Zhi. 2013 Dec;38(23):4099-103.

The antitussive activity assay for the root extraction of Disporum cantoniense was carried out with coughing mice induced by ammonia liquor. The results showed that the ethanol and water extractions of D. cantoniense possess strong antitussive activity, and the high dose of the former was better than positive control, and then the constituents of the ethanol extraction were separated and purified by various modern chromatographic techniques. Their structures were identified by physico-chemical properties and spectroscopic data. As a result, eight compounds were isolated and identified as stigmast-4-en-3-one(1), (22E, 24R)-ergosta-5, 7, 22-trien-3beta-ol(2), Obtucarbamate A(3), obtucarbamate B(4), neotigogenin(5), azo-2, 2'-bis[Z-(2,3-dihydroxy-4-methyl-5-methoxy) phenyl ethylene] (6),dimethyl {[carbonylbis (azanediyl)] bis( 2-methyl-5, 1-phenylene) j dicarbamate (7) , and quercetin-3-O-pB-D-glucopyranoside(8). All compounds were isolated from this plant for the first time, and the result of bioactivity-directed isolation showed that compounds 3, 4, and 6 had obvious effect on antitussive activity, and compound 6 had the same level as positive control.

Biotransformation of isofraxetin-6-O-beta-d-glucopyranoside by Angelica sinensis (Oliv.) Diels callus.[Pubmed:27919656]

Bioorg Med Chem Lett. 2017 Jan 15;27(2):248-253.

Isofraxetin-6-O-beta-d-glucopyranoside, identified from traditional medicinal herbal Xanthoceras sorbifolia Bunge, has been demonstrated to be a natural neuroinflammatory inhibitor. In order to obtain more derivatives with potential anti-neuroinflammatory effects, biotransformation was carried out. According to the characteristics of coumarin skeleton, suspension cultures of Angelica sinensis (Oliv.) Diels callus (A. sinensis callus) were employed because of the presence of diverse phenylpropanoids biosynthetic enzymes. As a result, 15 products were yielded from the suspension cultures, including a new coumarin: 8'-dehydroxymethyl cleomiscosin A (1), together with 14 known compounds. Their structures were elucidated by extensive spectroscopic analysis. Furthermore, the biotransformed pathways were discussed. Among them, compound 13 was transformed from isofraxetin-6-O-beta-d-glucopyranoside, while compounds 1-6, 10-12, 14-15 were derived from the culture medium stimulated by the substrate. The biotransformation processes include hydroxylation, oxidation and esterification. Furthermore, their inhibitory effects on lipopolysaccharide (LPS)-activated nitric oxide (NO) production were evaluated in BV2 microglial cells. It is worth noting that, 1, 1'-methanediylbis(4-methoxybenzene) (3), obtucarbamates A (5), 2-nonyl-4-hydroxyquinoline N-oxide (10) and 1H-indole-3-carbaldehyde (11) exhibited significant inhibitory effect against neuroinflammation with IC50 values at 1.22, 10.57, 1.02 and 0.76muM respectively, much stronger than that of the positive control minocycline (IC50 35.82muM).

Description

Obtucarbamate A isolated from Disporum cantoniense has antitussive activity.

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