3-beta-O-(cis-p-Coumaroyl)maslinic acid

Antimicrobial Triterpenoids from Licania heteromorpha.[Reference: WebLink]

Planta Medica, 2000, 66(8):768-769.

METHODS AND RESULTS:
Six triterpenoids having a lupane and oleane skeleton were isolated from the leaves and young branches of Licania heteromorpha Bentham var. heteromorpha and were identified as: betulinic acid 1, alphitolic acid 2, 3 beta-O-trans-p-coumaroyl alphitolic acid 3, 3 beta-O-cis-p-coumaroyl alphitolic acid 4, 3 beta-O-trans-p-coumaroyl maslinic acid 5, 3-beta-O-(cis-p-Coumaroyl)maslinic acid 6. The antimicrobial activity of these compounds was evaluated in vitro on clinically isolated microorganisms employing a microdilution method.
CONCLUSIONS:
Compounds 2, 3, 5, and 6 showed antimicrobial activity on Gram-positive bacteria and yeasts, whereas none of the six triterpenoids were active against Gram-negative organisms.

Chinese Pharmaceutical Journal,2010,45(11):825-828.

Isolation and identification of 3-O-p-coumaroyloxyl pentacyclic triterpenoids from Lysimachia clethroides Duby.[Reference: WebLink]

To isolate and identify the 3-O-p-coumaroyloxyl pentacyclic triterpenoids from acetoacetate extract of Lysimachia clethroides Duby, which showed significant cancer chemopreventive activities.
METHODS AND RESULTS:
The 3-O-p-coumaroyloxyl pentacyclic triterpenoids were isolated by using silica gel column chromatography, Sephadex LH - 20 chromatography MPLC, and Semi-HPLC. Their structures were elucidated with spectroscopic analysis (NMR, MS and IR). Six 3-O-p-coumaroyloxyl pentacyclic triterpenoids were isolated and identified as 3-beta-O-(cis-p-Coumaroyl)maslinic acid(I), 3-O-trans-p-coumaroyl maslinic acid (II), 3-O-cis-p-coumaroyl-2α-hydroxyursolic acid (III), 3-O-trans-p-coumaroyl-2α-hydroxyursolic acid (IV), 3-O-cis-p-coumaroyl tormentic acid (V) and 3-O-trans-p-coumaroyl tormentic acid (VI).
CONCLUSIONS:
All these compounds were obtained from the Lysimachia Genus for the first time.