4-HydroxybenzylamineCAS# 696-60-6 |
Quality Control & MSDS
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Chemical structure
![4-Hydroxybenzylamine](/media/images/struct/BCN1805.png)
3D structure
Cas No. | 696-60-6 | SDF | Download SDF |
PubChem ID | 97472 | Appearance | Cryst. |
Formula | C7H9NO | M.Wt | 123.15 |
Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
Chemical Name | 4-(aminomethyl)phenol | ||
SMILES | C1=CC(=CC=C1CN)O | ||
Standard InChIKey | RQJDUEKERVZLLU-UHFFFAOYSA-N | ||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. |
Description | 1. 4-Hydroxybenzaldehyde derivatives are inhibitors for GABA transaminase (GABA-T) and succinic semialdehyde dehydrogenase (SSADH), 4-Hydroxybenzylamine also shows the competitive inhibition on GABA-T with respect to GABA. |
Targets | GABA Receptor |
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4-Hydroxybenzylamine Dilution Calculator
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4-Hydroxybenzylamine Molarity Calculator
1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
1 mM | 8.1202 mL | 40.6009 mL | 81.2018 mL | 162.4036 mL | 203.0045 mL |
5 mM | 1.624 mL | 8.1202 mL | 16.2404 mL | 32.4807 mL | 40.6009 mL |
10 mM | 0.812 mL | 4.0601 mL | 8.1202 mL | 16.2404 mL | 20.3004 mL |
50 mM | 0.1624 mL | 0.812 mL | 1.624 mL | 3.2481 mL | 4.0601 mL |
100 mM | 0.0812 mL | 0.406 mL | 0.812 mL | 1.624 mL | 2.03 mL |
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. |
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Inhibition of GABA shunt enzymes' activity by 4-hydroxybenzaldehyde derivatives.[Pubmed:16290145]
Bioorg Med Chem Lett. 2006 Feb;16(3):592-5.
4-Hydroxybenzaldehyde (HBA) derivatives were examined as inhibitors for GABA transaminase (GABA-T) and succinic semialdehyde dehydrogenase (SSADH). Investigation of structure-activity relation revealed that a carbonyl group or an amino group as well as a hydroxy group at the para position of the benzene ring are important for both enzymes' inhibition. HBA was shown to give competitive inhibition of GABA-T with respect to alpha-ketoglutarate and competitive inhibition of SSADH. 4-Hydroxybenzylamine (HBM) also showed the competitive inhibition on GABA-T with respect to GABA. In conclusion, the inhibitory effects of HBA and HBM on both enzymes could result from the similarity between both molecules and the two enzymes' substrates in structure, as well as the conjugative effect of the benzene ring. This suggested that the presence of the benzene ring may be accepted by the active site of both enzymes, HBA and HBM may be considered as lead compounds to design novel GABA-T inhibitors.