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5'-Methoxynobiletin

CAS# 6965-36-2

5'-Methoxynobiletin

Catalog No. BCN8031----Order now to get a substantial discount!

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5'-Methoxynobiletin: 5mg Please Inquire In Stock
5'-Methoxynobiletin: 10mg Please Inquire In Stock
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Quality Control of 5'-Methoxynobiletin

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Chemical structure

5'-Methoxynobiletin

3D structure

Chemical Properties of 5'-Methoxynobiletin

Cas No. 6965-36-2 SDF Download SDF
PubChem ID 72815 Appearance Yellow powder
Formula C22H24O9 M.Wt 432.42
Type of Compound Flavonoids Storage Desiccate at -20°C
Synonyms 5,6,7,8,3',4',5'-heptamethoxyflavone
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 5,6,7,8-tetramethoxy-2-(3,4,5-trimethoxyphenyl)chromen-4-one
SMILES COC1=CC(=CC(=C1OC)OC)C2=CC(=O)C3=C(O2)C(=C(C(=C3OC)OC)OC)OC
Standard InChIKey UAELIRBOLQZEAT-UHFFFAOYSA-N
Standard InChI InChI=1S/C22H24O9/c1-24-14-8-11(9-15(25-2)17(14)26-3)13-10-12(23)16-18(27-4)20(28-5)22(30-7)21(29-6)19(16)31-13/h8-10H,1-7H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 5'-Methoxynobiletin

The herbs of Eupatorium coelestinum

Biological Activity of 5'-Methoxynobiletin

Description1. 5'-Methoxynobiletin may exhibit antinociceptive and anti-inflammatory activities in both formalin phases.
TargetsPGE | IL Receptor | TNF-α

5'-Methoxynobiletin Dilution Calculator

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5'-Methoxynobiletin Molarity Calculator

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Preparing Stock Solutions of 5'-Methoxynobiletin

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.3126 mL 11.5628 mL 23.1257 mL 46.2513 mL 57.8142 mL
5 mM 0.4625 mL 2.3126 mL 4.6251 mL 9.2503 mL 11.5628 mL
10 mM 0.2313 mL 1.1563 mL 2.3126 mL 4.6251 mL 5.7814 mL
50 mM 0.0463 mL 0.2313 mL 0.4625 mL 0.925 mL 1.1563 mL
100 mM 0.0231 mL 0.1156 mL 0.2313 mL 0.4625 mL 0.5781 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 5'-Methoxynobiletin

Simultaneous identification and quantification of polymethoxyflavones, coumarin and phenolic acids in Ageratum conyzoides by UPLC-ESI-QToF-MS and UPLC-PDA.[Pubmed:29843205]

J Pharm Biomed Anal. 2017 Oct 25;145:621-628.

Ageratum conyzoides L. is a plant widely used in traditional medicine of tropical and subtropical regions for its anti-inflammatory and antinociceptive properties. Nevertheless, the chemical composition of its medicinal preparation has not been yet accurately established. In this study, chromatographic methods were developed for the simultaneous identification and quantification of the main compounds in A. conyzoides aqueous extract, using UPLC-PDA-ESI-QToF-MS. The qualitative analyses defined by MS/MS analysis allowed the identification of 27 compounds in the aqueous extract, including the toxic pyrrolizidine alkaloids, phenolic acids, coumarin and polymethoxyflavones. Among the metabolites, twelve were detected for the first time in the species. The quantitative method was validated according to the official guidelines, demonstrating to be specific, linear, precise, accurate and sensitive for the quantification of chlorogenic acid, coumaric acid, coumarin (1,2-benzopyranone), 5,6,7,3',4',5'-hexamethoxyflavone, nobiletin, 5'-methoxynobiletin and eupalestin.

Antinociceptive and anti-inflammatory activities of standardized extract of polymethoxyflavones from Ageratum conyzoides.[Pubmed:27633406]

J Ethnopharmacol. 2016 Dec 24;194:369-377.

ETHNOPHARMACOLOGICAL RELEVANCE: Ageratum conyzoides L. is a plant widely used in traditional medicine in tropical and subtropical regions of the world due to its anti-inflammatory, antinociceptive and antibacterial properties. AIM OF THE STUDY: To characterize the standardized extract of polymethoxyflavones (SEPAc) from the plant and evaluate its antinociceptive and anti-inflammatory effects. MATERIALS AND METHODS: The SEPAc purified from the ethanol extract of the plant leaves was characterized by high resolution mass spectrometry and the methoxyflavones were quantified by a validated UPLC-PDA method. The antinociceptive and anti-inflammatory activities of the SEPAc were evaluated after oral administration on the acute nocifensive behavior of mice induced by formalin, prostaglandin E2 (PGE2) and proinflammatory cytokines (interleukin-1beta (IL-1beta)) and tumor necrosis factor-alpha (TNF-alpha) in mice. RESULTS: Qualitative analyses revealed the presence of seven methoxyflavones in the SEPAc, also a simple UPLC-PDA method was developed and validated for the quantification of 5,6,7,3',4',5'-hexametoxyflavone; nobiletin; 5'-methoxynobiletin and eupalestin, major compounds in the extract. The SEPAc exhibited antinociceptive and anti-inflammatory activities in both formalin phases, with significant inhibition of the paw edema formation and significant reduction of the nocifensive response induced by an intraplantar injection of PGE2 and intrathecal injection of interleukin-1beta. CONCLUSIONS: The SEPAc exhibited significant antinociceptive and anti-inflammatory effects. These results provided scientific suggestion of its potential as a source of new medicines to treat inflammatory diseases, such rheumatoid arthritis.

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