Morusignin LCAS# 149733-95-9 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 149733-95-9 | SDF | Download SDF |
| PubChem ID | 44258298.0 | Appearance | Powder |
| Formula | C25H26O7 | M.Wt | 438.48 |
| Type of Compound | Flavonoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 8-(2,4-dihydroxyphenyl)-5-hydroxy-7-(3-hydroxy-3-methylbutyl)-2,2-dimethylpyrano[3,2-g]chromen-6-one | ||
| SMILES | CC1(C=CC2=C(O1)C=C3C(=C2O)C(=O)C(=C(O3)C4=C(C=C(C=C4)O)O)CCC(C)(C)O)C | ||
| Standard InChIKey | XUHTYQLVSNYQKM-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C25H26O7/c1-24(2,30)9-7-16-22(29)20-19(31-23(16)14-6-5-13(26)11-17(14)27)12-18-15(21(20)28)8-10-25(3,4)32-18/h5-6,8,10-12,26-28,30H,7,9H2,1-4H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Morusignin L Dilution Calculator
Morusignin L Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.2806 mL | 11.403 mL | 22.8061 mL | 45.6121 mL | 57.0151 mL |
| 5 mM | 0.4561 mL | 2.2806 mL | 4.5612 mL | 9.1224 mL | 11.403 mL |
| 10 mM | 0.2281 mL | 1.1403 mL | 2.2806 mL | 4.5612 mL | 5.7015 mL |
| 50 mM | 0.0456 mL | 0.2281 mL | 0.4561 mL | 0.9122 mL | 1.1403 mL |
| 100 mM | 0.0228 mL | 0.114 mL | 0.2281 mL | 0.4561 mL | 0.5702 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Two novel compounds from the root bark of Morus alba L.[Pubmed:28521570]
Nat Prod Res. 2018 Jan;32(1):36-42.
Chemical investigation of the root bark of Morus alba led to the isolation of a new flavone, dioxycudraflavone A (1) and a new 2-arylbenzofuran, 5-hydroxyethyl moracin M (2), together with seven known compounds namely sanggenon V (3), morusin (4), Morusignin L (5), licoflavone C (6), moracin C (7), alfafuran (8) and mulberrofuran G (9). The structure elucidation of these compounds was based on analyses of spectroscopic data including 1D, 2D NMR and HR-ESI-MS. All compounds were evaluated for the alpha-glucosidase inhibitory and cytotoxic activities. Compounds 2-4, 8 and 9 exhibited strong alpha-glucosidase inhibitory activities with IC(50) less than 10 muM, while only 4 and 9 showed moderate cytotoxic effects against lung cancer cells.
Rapid, microwave-accelerated synthesis and anti-osteoporosis activities evaluation of Morusin scaffolds and Morusignin L scaffolds.[Pubmed:28427808]
Bioorg Med Chem Lett. 2017 Jun 1;27(11):2389-2396.
Described herein is a facile and efficient methodology toward the synthesis of Morusin scaffolds and Morusignin L scaffolds 4-9 and 12via a novel three-step approach (Michael addition or prenylation, cyclization and cyclization) and use a rapid, microwave-accelerated cyclization as the key step. Furthermore, their biological activities have been preliminarily demonstrated by in vitro evaluation for anti-osteoporosis activity. These Morusin, Morusignin L and newly synthesized compounds 5b, 6a, 8e, 8f greatly exhibited the highest potency, especially at the 10(-5)mol/L (P<0.01), and had good in vitro anti-osteoporosis activities using the commercially available standard drug Ipriflavone as a positive control. The mechanisms associated with anti-osteoporosis effects of these compounds may be through the inhibition of TRAP enzyme activity and bone resorption in osteoclasts, and promotion effect of osteoblast proliferation in vitro. The results indicated that Morusin scaffolds and Morusignin L scaffolds may be useful leads for further anti-osteoporosis activity screenings.
[Study on the chemical constituents of mori cortex].[Pubmed:24417147]
Zhong Yao Cai. 2013 Jul;36(7):1101-3.
OBJECTIVE: To study the chemical constituents of Mori Cortex. METHODS: The compounds from the dichloromethane-methanol extracts were isolated by the silica gel column chromatography, and their structures were identified by the spectral analysis and chemical evidence. RESULTS: Eight compounds were obtained and their structures were identified as 3-acetyl-beta-amyranol (1), neotocopherol (2), alpha-amyrin (3), clionasterol (4), betulinic acid (5), moracin O (6), morusin (7) and Morusignin L (8). CONCLUSION: Componds 2 and 4 are obtained from this plant for the first time.
