3,5,7-TrimethoxyflavoneCAS# 26964-29-4 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 26964-29-4 | SDF | Download SDF |
| PubChem ID | 117900.0 | Appearance | Powder |
| Formula | C18H16O5 | M.Wt | 312.32 |
| Type of Compound | Flavonoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 3,5,7-trimethoxy-2-phenylchromen-4-one | ||
| SMILES | COC1=CC2=C(C(=C1)OC)C(=O)C(=C(O2)C3=CC=CC=C3)OC | ||
| Standard InChIKey | CBTHKWVPSIGKMI-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C18H16O5/c1-20-12-9-13(21-2)15-14(10-12)23-17(18(22-3)16(15)19)11-7-5-4-6-8-11/h4-10H,1-3H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
3,5,7-Trimethoxyflavone Dilution Calculator
3,5,7-Trimethoxyflavone Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.2018 mL | 16.0092 mL | 32.0184 mL | 64.0369 mL | 80.0461 mL |
| 5 mM | 0.6404 mL | 3.2018 mL | 6.4037 mL | 12.8074 mL | 16.0092 mL |
| 10 mM | 0.3202 mL | 1.6009 mL | 3.2018 mL | 6.4037 mL | 8.0046 mL |
| 50 mM | 0.064 mL | 0.3202 mL | 0.6404 mL | 1.2807 mL | 1.6009 mL |
| 100 mM | 0.032 mL | 0.1601 mL | 0.3202 mL | 0.6404 mL | 0.8005 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- Micromarin F
Catalog No.:BCX1279
CAS No.:73292-93-0
- Palvanil
Catalog No.:BCX1278
CAS No.:69693-13-6
- N-Acetylcytisine
Catalog No.:BCX1277
CAS No.:6018-52-6
- Hispidol
Catalog No.:BCX1276
CAS No.:5786-54-9
- 2',4,4',6'-Tetramethoxychalcone
Catalog No.:BCX1275
CAS No.:94103-36-3
- 2'-O-Methylphloretin
Catalog No.:BCX1274
CAS No.:111316-17-7
- Phenoxodiol
Catalog No.:BCX1273
CAS No.:81267-65-4
- 6-Hydroxyluteolin
Catalog No.:BCX1272
CAS No.:18003-33-3
- Sinomenine N-oxide
Catalog No.:BCX1271
CAS No.:1000026-77-6
- Protoanemonin
Catalog No.:BCX1270
CAS No.:108-28-1
- Demethyldaphnoretin-7-O-glucoside
Catalog No.:BCX1269
CAS No.:438578-91-7
- Scheffoleoside A
Catalog No.:BCX1268
CAS No.:160669-23-8
- Ethyl rosmarinate
Catalog No.:BCX1281
CAS No.:174591-47-0
- 1-(2,6-Dimethoxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one
Catalog No.:BCX1282
CAS No.:85679-87-4
- 5-Hydroxy-3,7-dimethoxyflavone
Catalog No.:BCX1283
CAS No.:70786-48-0
- Morusignin L
Catalog No.:BCX1284
CAS No.:149733-95-9
- Napelline
Catalog No.:BCX1285
CAS No.:5008-52-6
- Isobellidifolin
Catalog No.:BCX1286
CAS No.:552-00-1
- Dihydrocatalpol
Catalog No.:BCX1287
CAS No.:6736-86-3
- Ajugose
Catalog No.:BCX1288
CAS No.:512-72-1
- Limocitrin 3-O-β-D-glucopyranoside
Catalog No.:BCX1289
CAS No.:38836-51-0
- Wistin
Catalog No.:BCX1290
CAS No.:19046-26-5
- Physcion-8-O-β-gentiobioside
Catalog No.:BCX1291
CAS No.:84268-38-2
- Chaparrinone
Catalog No.:BCX1292
CAS No.:22611-34-3
Improvement of Damage in Human Dermal Fibroblasts by 3,5,7-Trimethoxyflavone from Black Ginger (Kaempferia parviflora).[Pubmed:35204307]
Antioxidants (Basel). 2022 Feb 19;11(2):425.
Reactive oxygen species (ROS) are generated during intrinsic (chronological aging) and extrinsic (photoaging) skin aging. Therefore, antioxidants that inhibit ROS production may be involved in delaying skin aging. In this study, we investigated the potential effects of compounds isolated from black ginger, Kaempferia parviflora, a traditional medicinal plant, on normal human dermal fibroblasts in the context of inflammation and oxidative stress. The isolated compounds were structurally characterized as 5-hydroxy-7-methoxyflavone (1), 3,7-dimethoxy-5-hydroxyflavone (2), 5-hydroxy-3,7,3,4-tetramethoxyflavone (3), 7,4-dimethylapigenin (4), 3,7,4-trimethylkaempferol (5), and 3,5,7-Trimethoxyflavone (6), using nuclear magnetic resonance spectroscopy (NMR) and liquid chromatography-mass spectrometry (LC/MS) analyses. These flavonoids were first evaluated for their ability to suppress extracellular matrix degradation in normal human dermal fibroblasts. Of these, 3,5,7-Trimethoxyflavone (6) significantly inhibited the tumor necrosis factor (TNF)-alpha-induced high expression and secretion of matrix metalloproteinase (MMP)-1 by cells. We further found that 3,5,7-Trimethoxyflavone suppressed the excessive increase in ROS, mitogen-activated protein kinases (MAPKs), Akt, and cyclooxygenase-2 (COX-2)and increased heme oxygenase (HO)-1 expression. The expression of pro-inflammatory cytokines, including interleukin (IL)-1beta, IL-6, and IL-8, was also suppressed by 3,5,7-Trimethoxyflavone (6). Taken together, our results indicate that 3,5,7-Trimethoxyflavone (6) isolated from K. parviflora is a potential candidate for ameliorating skin damage.
