(RS)-(±)-SulpirideStandard selective D2-like antagonist CAS# 15676-16-1 |
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Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 15676-16-1 | SDF | Download SDF |
| PubChem ID | 688272 | Appearance | Powder |
| Formula | C15H23N3O4S | M.Wt | 341.42 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Synonyms | (-)-Sulpiride; (S)-(-)-Sulpiride; Levopraid; Levosulpirida; S-(-)-Sulpiride; Levosulpiridum | ||
| Solubility | DMSO : 100 mg/mL (292.89 mM; Need ultrasonic) | ||
| Chemical Name | N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-2-methoxy-5-sulfamoylbenzamide | ||
| SMILES | CCN1CCCC1CNC(=O)C2=C(C=CC(=C2)S(=O)(=O)N)OC | ||
| Standard InChIKey | BGRJTUBHPOOWDU-NSHDSACASA-N | ||
| Standard InChI | InChI=1S/C15H23N3O4S/c1-3-18-8-4-5-11(18)10-17-15(19)13-9-12(23(16,20)21)6-7-14(13)22-2/h6-7,9,11H,3-5,8,10H2,1-2H3,(H,17,19)(H2,16,20,21)/t11-/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Standard D2-like dopamine receptor antagonist. (S)-(-)-Sulpiride also available. |
(RS)-(±)-Sulpiride Dilution Calculator
(RS)-(±)-Sulpiride Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.9289 mL | 14.6447 mL | 29.2894 mL | 58.5789 mL | 73.2236 mL |
| 5 mM | 0.5858 mL | 2.9289 mL | 5.8579 mL | 11.7158 mL | 14.6447 mL |
| 10 mM | 0.2929 mL | 1.4645 mL | 2.9289 mL | 5.8579 mL | 7.3224 mL |
| 50 mM | 0.0586 mL | 0.2929 mL | 0.5858 mL | 1.1716 mL | 1.4645 mL |
| 100 mM | 0.0293 mL | 0.1464 mL | 0.2929 mL | 0.5858 mL | 0.7322 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Dopamine receptor pharmacology.[Pubmed:7940991]
Trends Pharmacol Sci. 1994 Jul;15(7):264-70.
Dopamine receptors are the primary targets in the treatment of schizophrenia, Parkinson's disease, and Huntington's chorea, and are discussed in this review by Philip Seeman and Hubert Van Tol. Improved therapy may be obtained by drugs that selectively target a particular subtype of dopamine receptor. Most antipsychotic drugs block D2 receptors in direct correlation to clinical potency, except clozapine, which prefers D4 receptors. D1 and D2 receptors can enhance each other's actions, possibly through subunits of the G proteins. In schizophrenia, the D2 and D3 receptor density is elevated by 10%, while the D4 receptor density is elevated by 600%. Therefore, D4 receptors may be a target for future antipsychotic drugs. While antipsychotics originally helped to discover dopamine receptors, the five cloned dopamine receptors are now facilitating the discovery of selective antipsychotic and antiparkinson drugs.
Dopamine D4 receptors bind inactive (+)-aporphines, suggesting neuroleptic role. Sulpiride not stereoselective.[Pubmed:8097160]
Eur J Pharmacol. 1993 Mar 16;233(1):173-4.
In order to identify new atypical antipsychotic drugs which are more selective for the human dopamine D4 receptor than for the human dopamine D2 (long) receptor, we tested enantiomer pairs of dopamine agonists and dopamine antagonists on the expressed proteins of these cloned receptors. The (+)-aporphines ((+)-N-propyl-norapomorphine, 11-OH-N-propyl-norapomorphine and (+)-apomorphine) bound to the dopamine D4 receptor with selectivities up to 20 times greater than to the dopamine D2 receptor, suggesting that these pharmacologically inactive enantiomers may succeed as atypical neuroleptics.
