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cis-Khellactone

CAS# 15645-11-1

cis-Khellactone

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Chemical structure

cis-Khellactone

3D structure

Chemical Properties of cis-Khellactone

Cas No. 15645-11-1 SDF Download SDF
PubChem ID 11097348 Appearance Cryst.
Formula C14H14O5 M.Wt 262.3
Type of Compound Coumarins Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (9S,10S)-9,10-dihydroxy-8,8-dimethyl-9,10-dihydropyrano[2,3-f]chromen-2-one
SMILES CC1(C(C(C2=C(O1)C=CC3=C2OC(=O)C=C3)O)O)C
Standard InChIKey HKXQUNNSKMWIKJ-AAEUAGOBSA-N
Standard InChI InChI=1S/C14H14O5/c1-14(2)13(17)11(16)10-8(19-14)5-3-7-4-6-9(15)18-12(7)10/h3-6,11,13,16-17H,1-2H3/t11-,13-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of cis-Khellactone

The roots of Angelica sinensis

Biological Activity of cis-Khellactone

Descriptioncis-Khellactone is a natural product from Angelica sinensis.
In vitro

Two new coumarins from the chloroform extract of Angelica urumiensis from Iran.[Pubmed: 20410639]

Chem Pharm Bull (Tokyo). 2010 Apr;58(4):546-8.

The aerial parts of several Angelica species of the Apiaceae as natural medicine, are rich sources of various coumarins with biological, to a lesser extent, toxicological activities.
METHODS AND RESULTS:
From the chloroform extract of the aerial parts of Angelica urumiensis MOZAFF. two new coumarins (1, 2), together with six known coumarins and two known flavonoids were isolated. On the basis of comprehensive spectroscopic analyses, including electron ionization-mass spectra (EI-MS), (1)H-NMR, (13)C-NMR, 1D nuclear Overhauser effect (NOE), distortionless enchancement by polarization transfer (DEPT), H, H correlation spectroscopy (COSY), heteronuclear multiple quantum coherence (HMQC), heteronuclear multiple bond correlation (HMBC), rotating frame Overhauser enhancement spectroscopy (ROESY) spectra and comparison with spectral data of known compounds, the structure of new compounds were established as pyranocoumarin dimmer (1) and (+)-8,9-dihydro-8-(2-hydroxypropan-2-yl)-2-oxo-2H-furo[2,3-h]chromen-9-yl-3-methylbut-2-enoate (2). The eight known compounds (3-10) were isosamidin, laserpitin, pteryxin, isolaserpitin, cis-Khellactone, angelicin, genkwanin and salvigenin, respectively. These known structures are isolated from the aerial parts of A. urumiensis for the first time.
CONCLUSIONS:
Antioxidant activities of the two new coumarins were evaluated by using 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay and exhibited a moderate antioxidant activity.

cis-Khellactone Dilution Calculator

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cis-Khellactone Molarity Calculator

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Preparing Stock Solutions of cis-Khellactone

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.8124 mL 19.0621 mL 38.1243 mL 76.2486 mL 95.3107 mL
5 mM 0.7625 mL 3.8124 mL 7.6249 mL 15.2497 mL 19.0621 mL
10 mM 0.3812 mL 1.9062 mL 3.8124 mL 7.6249 mL 9.5311 mL
50 mM 0.0762 mL 0.3812 mL 0.7625 mL 1.525 mL 1.9062 mL
100 mM 0.0381 mL 0.1906 mL 0.3812 mL 0.7625 mL 0.9531 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on cis-Khellactone

Two new coumarins from the chloroform extract of Angelica urumiensis from Iran.[Pubmed:20410639]

Chem Pharm Bull (Tokyo). 2010 Apr;58(4):546-8.

The aerial parts of several Angelica species of the Apiaceae as natural medicine, are rich sources of various coumarins with biological, to a lesser extent, toxicological activities. From the chloroform extract of the aerial parts of Angelica urumiensis MOZAFF. two new coumarins (1, 2), together with six known coumarins and two known flavonoids were isolated. On the basis of comprehensive spectroscopic analyses, including electron ionization-mass spectra (EI-MS), (1)H-NMR, (13)C-NMR, 1D nuclear Overhauser effect (NOE), distortionless enchancement by polarization transfer (DEPT), H, H correlation spectroscopy (COSY), heteronuclear multiple quantum coherence (HMQC), heteronuclear multiple bond correlation (HMBC), rotating frame Overhauser enhancement spectroscopy (ROESY) spectra and comparison with spectral data of known compounds, the structure of new compounds were established as pyranocoumarin dimmer (1) and (+)-8,9-dihydro-8-(2-hydroxypropan-2-yl)-2-oxo-2H-furo[2,3-h]chromen-9-yl-3-methy lbut-2-enoate (2). The eight known compounds (3-10) were isosamidin, laserpitin, pteryxin, isolaserpitin, cis-Khellactone, angelicin, genkwanin and salvigenin, respectively. These known structures are isolated from the aerial parts of A. urumiensis for the first time. Antioxidant activities of the two new coumarins were evaluated by using 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay and exhibited a moderate antioxidant activity.

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