KhellactoneCAS# 24144-61-4 |
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Quality Control & MSDS
3D structure
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Number of papers citing our products
| Cas No. | 24144-61-4 | SDF | Download SDF |
| PubChem ID | 455821 | Appearance | Powder |
| Formula | C14H14O5 | M.Wt | 262.3 |
| Type of Compound | Coumarins | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (9R,10R)-9,10-dihydroxy-8,8-dimethyl-9,10-dihydropyrano[2,3-f]chromen-2-one | ||
| SMILES | CC1(C(C(C2=C(O1)C=CC3=C2OC(=O)C=C3)O)O)C | ||
| Standard InChIKey | HKXQUNNSKMWIKJ-DGCLKSJQSA-N | ||
| Standard InChI | InChI=1S/C14H14O5/c1-14(2)13(17)11(16)10-8(19-14)5-3-7-4-6-9(15)18-12(7)10/h3-6,11,13,16-17H,1-2H3/t11-,13-/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Khellactone shows antitumor activity,it can suppress the growth of NCI-H460 tumor cells. 2. (+)-4'-cis-Khellactone and (+)-3'-cis-khellactone have antiplasmodial activities, they show notable inhibitory activity against -sensitive strains of with IC(50) values from 1.5 and 2.4 microM. |
| Targets | Antifection |
Khellactone Dilution Calculator
Khellactone Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.8124 mL | 19.0621 mL | 38.1243 mL | 76.2486 mL | 95.3107 mL |
| 5 mM | 0.7625 mL | 3.8124 mL | 7.6249 mL | 15.2497 mL | 19.0621 mL |
| 10 mM | 0.3812 mL | 1.9062 mL | 3.8124 mL | 7.6249 mL | 9.5311 mL |
| 50 mM | 0.0762 mL | 0.3812 mL | 0.7625 mL | 1.525 mL | 1.9062 mL |
| 100 mM | 0.0381 mL | 0.1906 mL | 0.3812 mL | 0.7625 mL | 0.9531 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Isolation of coumarins and ferulate from the roots of Angelica purpuraefolia and the antitumor activity of khellactone.[Pubmed:17236175]
Phytother Res. 2007 May;21(5):406-9.
A new coumarin, hydroxylomatin (1), was isolated from the CHCl(3)-soluble fraction of the roots of Angelica purpuraefolia, along with one ferulate (2) and three other known coumarins (3-5) including Khellactone (3). The structure of hydroxylomatin (1) was determined to be 3'beta,5'-dihydroxy-3',4'-dihydroseselin (1) by spectroscopic means including 2D-NMR. The modified Mosher's method was used to determine the chiral center at C-1 of compound 2. Khellactone (3) is a major compound of the roots of A. purpuraefolia. This study also examined the antitumor activity of Khellactone (3) using a LLC mouse lung carcinoma in the BDF-1 mice and a NCI-H460 human lung carcinoma in a human tumor xenograft model in nude mice. This compound (3) inhibited LLC tumor growth with a T/C (mean value of treated group/mean value of control group) value of 12.9% at a dose of 5 mg/kg and 33.2% at a dose of 10 mg/kg, respectively, in a dose-dependent manner. In addition, it suppressed the growth of NCI-H460 tumor cells, accounting for 81.4% at a dose of 10 mg/kg in nude mice.
Antiplasmodial and cytotoxic activity of khellactone derivatives from Angelica purpuraefolia Chung.[Pubmed:19960419]
Phytother Res. 2010 Mar;24(3):469-71.
The methanolic extract of the rhizomes parts of Agelica purpuraefolia was investigated for its activity against chloroquine-sensitive strains of Plasmodium falciparum using the parasite lactate dehydrogenase assay method. Two natural Khellactone, (+)-4'-Decanoyl-cis-Khellactone (1) and (+)-3'-Decanoyl-cis-Khellactone (2) were isolated from the rhizomes parts of A. purpuraefolia. Two compounds were evaluated for in vitro antiplasmodial activities as well as their cytotoxic potential on SK-OV-3 cancer cell line cells. Compounds 1, 2 showed notable growth inhibitory activity against chloroquine-sensitive strains of Plasmodium falciparum with IC(50) values from 1.5 and 2.4 microM. This compound showed no significant cytotoxicity (IC(50) > 100 microM) evaluated using SK-OV-3 cancer cell line cells. This is the first report on the antiplasmodial activity of the compounds from A. purpuraefolia.
