Mephedrone hydrochlorideInhibits synaptosomal dopamine and 5-HT uptake CAS# 1189726-22-4 |
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Quality Control & MSDS
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| Cas No. | 1189726-22-4 | SDF | Download SDF |
| PubChem ID | 46782120 | Appearance | Powder |
| Formula | C11H16ClNO | M.Wt | 213.7 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble to 100 mM in water and to 100 mM in DMSO | ||
| Chemical Name | 2-(methylamino)-1-(4-methylphenyl)propan-1-one;hydrochloride | ||
| SMILES | CC1=CC=C(C=C1)C(=O)C(C)NC.Cl | ||
| Standard InChIKey | DLQZFTUKJGRPLZ-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C11H15NO.ClH/c1-8-4-6-10(7-5-8)11(13)9(2)12-3;/h4-7,9,12H,1-3H3;1H | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Inhibits striatal dopamine uptake and hippocampal 5-HT uptake in synaptosomes (IC50 values are 467 and 558 nM respectively). Administration causes a decrease in dopamine and 5-HT transporter function. Synthetic CNS stimulant; brain penetrant. |
Mephedrone hydrochloride Dilution Calculator
Mephedrone hydrochloride Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 4.6795 mL | 23.3973 mL | 46.7946 mL | 93.5891 mL | 116.9864 mL |
| 5 mM | 0.9359 mL | 4.6795 mL | 9.3589 mL | 18.7178 mL | 23.3973 mL |
| 10 mM | 0.4679 mL | 2.3397 mL | 4.6795 mL | 9.3589 mL | 11.6986 mL |
| 50 mM | 0.0936 mL | 0.4679 mL | 0.9359 mL | 1.8718 mL | 2.3397 mL |
| 100 mM | 0.0468 mL | 0.234 mL | 0.4679 mL | 0.9359 mL | 1.1699 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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'Smoking' mephedrone: the identification of the pyrolysis products of 4-methylmethcathinone hydrochloride.[Pubmed:22641432]
Drug Test Anal. 2013 May;5(5):291-305.
The ring-substituted cathinone - mephedrone - has gained popularity among recreational drug users over the past several years. It is generally consumed orally or by snorting but reports indicate that it is also ingested by vaporization/inhalation. This study examines the pyrolysis products produced by heating mephedrone under using simulated 'meth pipe' conditions. Thirteen pyrolysis products were identified, the major ones being iso-mephedrone, 4-methylpropiophenone, 4-methylphenylacetone, two pyrazine derivatives formed by dimerization of mephedrone, N-methylated mephedrone (N,N,4-trimethylcatinone), two hydroxylated oxidation products and a diketone. Other minor products formed were identified as 4-methylacetophenone, two alpha-chloro ketones and N-methylated iso-mephedrone.
4-Methylmethcathinone (mephedrone): neuropharmacological effects of a designer stimulant of abuse.[Pubmed:21810934]
J Pharmacol Exp Ther. 2011 Nov;339(2):530-6.
The designer stimulant 4-methylmethcathinone (mephedrone) is among the most popular of the derivatives of the naturally occurring psychostimulant cathinone. Mephedrone has been readily available for legal purchase both online and in some stores and has been promoted by aggressive Web-based marketing. Its abuse in many countries, including the United States, is a serious public health concern. Owing largely to its recent emergence, there are no formal pharmacodynamic or pharmacokinetic studies of mephedrone. Accordingly, the purpose of this study was to evaluate effects of this agent in a rat model. Results revealed that, similar to methylenedioxymethamphetamine, methamphetamine, and methcathinone, repeated mephedrone injections (4x 10 or 25 mg/kg s.c. per injection, 2-h intervals, administered in a pattern used frequently to mimic psychostimulant "binge" treatment) cause a rapid decrease in striatal dopamine (DA) and hippocampal serotonin (5-hydroxytryptamine; 5HT) transporter function. Mephedrone also inhibited both synaptosomal DA and 5HT uptake. Like methylenedioxymethamphetamine, but unlike methamphetamine or methcathinone, repeated mephedrone administrations also caused persistent serotonergic, but not dopaminergic, deficits. However, mephedrone caused DA release from a striatal suspension approaching that of methamphetamine and was self-administered by rodents. A method was developed to assess mephedrone concentrations in rat brain and plasma, and mephedrone levels were determined 1 h after a binge treatment. These data demonstrate that mephedrone has a unique pharmacological profile with both abuse liability and neurotoxic potential.
