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Lettowienolide

CAS# 1189105-39-2

Lettowienolide

Catalog No. BCN8038----Order now to get a substantial discount!

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Lettowienolide: 5mg Please Inquire In Stock
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Quality Control of Lettowienolide

Number of papers citing our products

Chemical structure

Lettowienolide

3D structure

Chemical Properties of Lettowienolide

Cas No. 1189105-39-2 SDF Download SDF
PubChem ID 102025309 Appearance Powder
Formula C18H22O3 M.Wt 286.37
Type of Compound Phenols Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 7-[(2E)-3,7-dimethylocta-2,6-dienyl]-5-hydroxy-3H-1-benzofuran-2-one
SMILES CC(=CCCC(=CCC1=C2C(=CC(=C1)O)CC(=O)O2)C)C
Standard InChIKey BQSTWVNVLQVIEE-NTUHNPAUSA-N
Standard InChI InChI=1S/C18H22O3/c1-12(2)5-4-6-13(3)7-8-14-9-16(19)10-15-11-17(20)21-18(14)15/h5,7,9-10,19H,4,6,8,11H2,1-3H3/b13-7+
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Lettowienolide

The herbs of Lettowianthus stellatus

Biological Activity of Lettowienolide

Description1. Lettowienolide exhibits mild in vitro activity against the Plasmodium falciparum malaria parasite ( IC(50) approximately 20 microg/mL).
TargetsAntifection

Lettowienolide Dilution Calculator

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Lettowienolide Molarity Calculator

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Preparing Stock Solutions of Lettowienolide

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.492 mL 17.4599 mL 34.9199 mL 69.8397 mL 87.2996 mL
5 mM 0.6984 mL 3.492 mL 6.984 mL 13.9679 mL 17.4599 mL
10 mM 0.3492 mL 1.746 mL 3.492 mL 6.984 mL 8.73 mL
50 mM 0.0698 mL 0.3492 mL 0.6984 mL 1.3968 mL 1.746 mL
100 mM 0.0349 mL 0.1746 mL 0.3492 mL 0.6984 mL 0.873 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Lettowienolide

Geranylbenzoquinonoids from Lettowianthus stellatus fruits.[Pubmed:20432152]

Nat Prod Res. 2010 May;24(8):710-7.

The geranylbenzoquinonoids 7-(3,7-dimethylocta-2,6-dienyl)-5-hydroxy-3H-benzofuran-2-one (Lettowienolide), dimethyl 2,3-bis-[5-(3,7-dimethylocta-2,6-dienyl)-3,6-dioxocyclohexa-1,4-dienyl]-succinate (lettowiquinone), 2-(3,7-dimethylocta-2,6-dienyl)-6-[7-(3,7-dimethylocta-2,6-dienyl)-5-hydroxybenzo furan-2-yl]-[1,4]benzoquinone (lettowifuraquinone), methyl [3-(3,7-dimethylocta-2,6-dienyl)-6-methyl-5-(3-methylbut-2-enyl)-1,4-dioxo-1,5, 8,8a-tetrahydro-4H-nathphalen-4a-yl)]-acetate (lettowinone) and methyl [6-hydroxy-2-methyl-2-(4-methylpent-3-enyl)-2H-chromen-8-yl]-acetate (lettowipyraquinol) were isolated from fruits of Lettowianthus stellatus Diels, together with juvenile hormone III and 7-octadecen-9-ynoic acid. Lettowienolide and lettowiquinone exhibited mild in vitro activity against the Plasmodium falciparum malaria parasite (each IC(50) approximately 20 microg mL(-1)). Structural determination was achieved based on extensive analysis of spectroscopic data.

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