Cocaine hydrochlorideInhibitor of monoamine transporters CAS# 53-21-4 |
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Quality Control & MSDS
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| Cas No. | 53-21-4 | SDF | Download SDF |
| PubChem ID | 656832 | Appearance | Powder |
| Formula | C17H22ClNO4 | M.Wt | 339.81 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble to 100 mM in water | ||
| Chemical Name | 3β-Hydroxy-1αH,5αH-tropane-2β-carboxyli | ||
| SMILES | [Cl-].COC(=O)[C@H]1[C@H](C[C@H]2CC[C@H]1N2C)OC(=O)c3ccccc3.[H+] | ||
| Standard InChIKey | PIQVDUKEQYOJNR-RWXTUVLLSA-N | ||
| Standard InChI | InChI=1S/C17H21NO4.ClH/c1-18-12-8-9-13(18)15(17(20)21-2)14(10-12)22-16(19)11-6-4-3-5-7-11;/h3-7,12-15H,8-10H2,1-2H3;1H/t12-,13-,14+,15-;/m1./s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Competitive inhibitor of monoamine neurotransmitter transporters. Inhibits dopamine (DAT), serotonin (SERT) and noradrenalin (NET) transporters with Ki values are 267, 392 and 872 nM respectively. Psychostimulant. |
Cocaine hydrochloride Dilution Calculator
Cocaine hydrochloride Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.9428 mL | 14.7141 mL | 29.4282 mL | 58.8564 mL | 73.5705 mL |
| 5 mM | 0.5886 mL | 2.9428 mL | 5.8856 mL | 11.7713 mL | 14.7141 mL |
| 10 mM | 0.2943 mL | 1.4714 mL | 2.9428 mL | 5.8856 mL | 7.3571 mL |
| 50 mM | 0.0589 mL | 0.2943 mL | 0.5886 mL | 1.1771 mL | 1.4714 mL |
| 100 mM | 0.0294 mL | 0.1471 mL | 0.2943 mL | 0.5886 mL | 0.7357 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Long-term Stability of Cocaine Hydrochloride Aqueous Solution 50 mg/mL (5%) at Room Temperature and at 5 degrees C +/- 3 degrees C in Glass Bottles.[Pubmed:26714368]
Int J Pharm Compd. 2015 May-Jun;19(3):268-70.
The objective of this study was to investigate the stability of Cocaine hydrochloride 50 mg/mL (5%) aqueous solution stored in glass bottles at 5 degrees C +/- 3 degrees C or at room temperature. Ten bottles of Cocaine hydrochloride 50 mg/mL were prepared under aseptic conditions. Five were stored at 5 degrees C +/- 3 degrees C and five at room temperature. pH measurements, optic density measurements at different wave-lengths, and optic microscopic observations were performed periodically during the storage. A forced-degradation test with hydrochloric acid 12M and NaOH 5M with and without heating at 100 degrees C was also performed. The concentrations were measured by high-pressure liquid chromatography with photodiode-array detection. Stability of the solutions was defined as the period for which the one-sided 95% confidence interval of the common regression line remains superior to 90% of the initial concentration as recommended by the U.S. Food and Drug Administration. The forced-degradation tests did not influence the chromatographic peaks of the studied component. No significant change of optic density was seen and no crystals were observed with the optic microscope during the study. The solutions stored at 5 degrees C +/- 3 degrees C or at room temperature maintained 90% of their concentration after 24 days. During this period, the pH of the solution decreased from 5.39 to 4.34 at 5 degrees C +/- 3 degrees C and from 5.37 to 3.44 at room temperature. In order to alleviate adverse reactions to the eye with too low pH, we propose a period of validity of 15 days at 5 degrees C +/- 3 degrees C and 48 hours at room temperature. During this period, the degradation of the preparation was lower than 10%, and the values of pH were higher than 4.0.
Headspace-gas chromatographic-mass spectrometric analysis of South American commercial solvents and their use in the illicit conversion of cocaine base to cocaine hydrochloride.[Pubmed:25047142]
J Forensic Sci. 2015 Jan;60(1):45-53.
This study presents data that establish the makeup of solvents utilized in illicit Cocaine hydrochloride production, as determined via the identification of the occluded solvents in the crystal matrix of the final product. The occluded solvent ratios can differ dramatically from the ratios of the original processing solvents. Additionally, the presented data suggest the diversion of commercial solvents to illicit Cocaine hydrochloride laboratories. Thirty-five commercial solvents were obtained from five chemical manufacturing companies in South America. Each solvent was qualitatively and quantitatively analyzed using static headspace-gas chromatography-mass spectrometry (HS-GC-MS). After obtaining the chemical profile for each commercial solvent, solvents and/or solvent mixtures were prepared to be comparable in composition to several of the commercial products. Over 90 individual batches of Cocaine hydrochloride were prepared from cocaine base using these solvents or solvent mixtures, which match those most commonly employed in clandestine laboratories. Additionally, a number of unique manufacturing by-products produced from processing solvents were identified, and their significance is discussed.
Functional photoacoustic imaging to observe regional brain activation induced by cocaine hydrochloride.[Pubmed:21950909]
J Biomed Opt. 2011 Sep;16(9):090506.
Photoacoustic microscopy (PAM) was used to detect small animal brain activation in response to drug abuse. Cocaine hydrochloride in saline solution was injected into the blood stream of Sprague Dawley rats through tail veins. The rat brain functional change in response to the injection of drug was then monitored by the PAM technique. Images in the coronal view of the rat brain at the locations of 1.2 and 3.4 mm posterior to bregma were obtained. The resulted photoacoustic (PA) images showed the regional changes in the blood volume. Additionally, the regional changes in blood oxygenation were also presented. The results demonstrated that PA imaging is capable of monitoring regional hemodynamic changes induced by drug abuse.
Correlation of cocaine hydrochloride samples seized in Brazil based on determination of residual solvents: an innovative chemometric method for determination of linkage thresholds.[Pubmed:23330818]
Anal Chem. 2013 Feb 19;85(4):2457-64.
Cocaine sample correlation provides important information in the identification of traffic networks. However, available methods for estimating if samples are linked or not require the use of previous police investigation and forensic expert knowledge regarding the number of classes and provide thresholds that are both static and data set specific. In this paper, a novel unsupervised linkage threshold method (ULT) based on chemometric analysis is described and applied to the analysis of headspace gas chromatography mass spectrometry (HS-GC/MS) data of more than 250 real Cocaine hydrochloride samples seized by Brazilian Federal Police. The method is capable of establishing linkage thresholds that do not require any prior information about the number of classes or distribution of the samples and can be dynamically updated as the data set changes. It is envisaged that the ULT method may also be applied to other forensic expertise areas where limited population knowledge is available and data sets are continually modified with the inflow of new information.
Differential effects of stimulants on monoaminergic transporters: pharmacological consequences and implications for neurotoxicity.[Pubmed:11011026]
Eur J Pharmacol. 2000 Oct 6;406(1):1-13.
Many psychostimulants alter plasmalemmal monoaminergic transporter function. Some, such as cocaine, prevent the reuptake of newly released dopamine, serotonin or norepinephrine into their associated neurons. Others, such as the amphetamines, facilitate release of these transmitters into the extraneuronal space by causing a reversal of function of these carrier proteins. An understanding of how psychostimulants regulate the function of not only plasmalemmal, but also vesicular monoamine transporter function is important to appreciate the pharmacological and sometimes neurotoxic consequences of administering these drugs, as well as the physiological regulation of these carrier proteins. Hence, this review will describe recent ex vivo studies investigating the rapid and differential affects of several stimulants on both plasmalemmal and vesicular monoamine transporter function.
