CDI (1,1′-Carbonyldiimidazole)Coupling agent for synthesis of dipolar polyamides CAS# 530-62-1 |
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Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
Cas No. | 530-62-1 | SDF | Download SDF |
PubChem ID | 68263 | Appearance | Powder |
Formula | C7H6N4O | M.Wt | 162.15 |
Type of Compound | N/A | Storage | Desiccate at -20°C |
Solubility | Soluble in water or 1% acetic acid | ||
Chemical Name | di(imidazol-1-yl)methanone | ||
SMILES | C1=CN(C=N1)C(=O)N2C=CN=C2 | ||
Standard InChIKey | PFKFTWBEEFSNDU-UHFFFAOYSA-N | ||
Standard InChI | InChI=1S/C7H6N4O/c12-7(10-3-1-8-5-10)11-4-2-9-6-11/h1-6H | ||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. |
CDI (1,1′-Carbonyldiimidazole) Dilution Calculator
CDI (1,1′-Carbonyldiimidazole) Molarity Calculator
1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
1 mM | 6.1671 mL | 30.8356 mL | 61.6713 mL | 123.3426 mL | 154.1782 mL |
5 mM | 1.2334 mL | 6.1671 mL | 12.3343 mL | 24.6685 mL | 30.8356 mL |
10 mM | 0.6167 mL | 3.0836 mL | 6.1671 mL | 12.3343 mL | 15.4178 mL |
50 mM | 0.1233 mL | 0.6167 mL | 1.2334 mL | 2.4669 mL | 3.0836 mL |
100 mM | 0.0617 mL | 0.3084 mL | 0.6167 mL | 1.2334 mL | 1.5418 mL |
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. |
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IC50: Not available.
The common method of peptide synthesis is not feasible for industry use due to its poor yields. CDI, a new peptide forming reagent, is applied recently as a more direct agent for the formation of acyl-imidazoles. [1]
In vitro: CDI can be prepared straightforwardly by the reaction of phosgene with four equivalents of imidazole under anhydrous conditions. It served as a convenient reagent for peptide synthesis since its side products, carbon dioxide and imidazole, were safe. Moreover, the carbon dioxide evolution was suggested to provide driving force for the peptide synthesis. A typical peptide-formation reaction was started by dissolving 0.010 mole acylamino acid in 10 ml tetrahydrofuran (THF), and after this, the evolution of carbon dioxide could be immediately observed. An hour later, the required amino acid or peptide ester was added with an amount of 0.010 molar. The reaction would be last for 15 min, but longer standing is probably beneficial. The formed peptide was then purified by wiping off the solvent under vacuum followed by washing the residue with acid, saturated bicarbonate and finally water.[1]
In vivo: So far, no in vivo data has been reported.
Clinical trial: So far, no clinical trial has been conducted.
Reference:
[1] Paul R, Anderson GW. N,N'-Carbonyldiimidazole, a new peptide forming reagent. J. Am. Chem. Soc. 1960 Sep; 82: 4597-600.
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1,1'-Carbonyldiimidazole (CDI) Mediated Coupling and Cyclization To Generate [1,2,4]Triazolo[4,3-a]pyridines.[Pubmed:26808327]
Org Lett. 2016 Feb 5;18(3):560-3.
An operationally efficient CDI mediated tandem coupling and cyclization reaction to generate [1,2,4]triazolo[4,3-a]pyridines has been reported. The reaction conditions and scope were investigated, and the methodology was demonstrated in batch mode as well as in a continuous process.