CDI (1,1′-Carbonyldiimidazole)

Coupling agent for synthesis of dipolar polyamides CAS# 530-62-1

CDI (1,1′-Carbonyldiimidazole)

Catalog No. BCC2809----Order now to get a substantial discount!

Product Name & Size Price Stock
CDI (1,1′-Carbonyldiimidazole): 5mg $6 In Stock
CDI (1,1′-Carbonyldiimidazole): 10mg Please Inquire In Stock
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Chemical structure

CDI (1,1′-Carbonyldiimidazole)

3D structure

Chemical Properties of CDI (1,1′-Carbonyldiimidazole)

Cas No. 530-62-1 SDF Download SDF
PubChem ID 68263 Appearance Powder
Formula C7H6N4O M.Wt 162.15
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble in water or 1% acetic acid
Chemical Name di(imidazol-1-yl)methanone
SMILES C1=CN(C=N1)C(=O)N2C=CN=C2
Standard InChIKey PFKFTWBEEFSNDU-UHFFFAOYSA-N
Standard InChI InChI=1S/C7H6N4O/c12-7(10-3-1-8-5-10)11-4-2-9-6-11/h1-6H
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

CDI (1,1′-Carbonyldiimidazole) Dilution Calculator

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CDI (1,1′-Carbonyldiimidazole) Molarity Calculator

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Preparing Stock Solutions of CDI (1,1′-Carbonyldiimidazole)

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 6.1671 mL 30.8356 mL 61.6713 mL 123.3426 mL 154.1782 mL
5 mM 1.2334 mL 6.1671 mL 12.3343 mL 24.6685 mL 30.8356 mL
10 mM 0.6167 mL 3.0836 mL 6.1671 mL 12.3343 mL 15.4178 mL
50 mM 0.1233 mL 0.6167 mL 1.2334 mL 2.4669 mL 3.0836 mL
100 mM 0.0617 mL 0.3084 mL 0.6167 mL 1.2334 mL 1.5418 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Background on CDI (1,1′-Carbonyldiimidazole)

IC50: Not available.

The common method of peptide synthesis is not feasible for industry use due to its poor yields. CDI, a new peptide forming reagent, is applied recently as a more direct agent for the formation of acyl-imidazoles. [1]

In vitro: CDI can be prepared straightforwardly by the reaction of phosgene with four equivalents of imidazole under anhydrous conditions. It served as a convenient reagent for peptide synthesis since its side products, carbon dioxide and imidazole, were safe. Moreover, the carbon dioxide evolution was suggested to provide driving force for the peptide synthesis. A typical peptide-formation reaction was started by dissolving 0.010 mole acylamino acid in 10 ml tetrahydrofuran (THF), and after this, the evolution of carbon dioxide could be immediately observed. An hour later, the required amino acid or peptide ester was added with an amount of 0.010 molar. The reaction would be last for 15 min, but longer standing is probably beneficial. The formed peptide was then purified by wiping off the solvent under vacuum followed by washing the residue with acid, saturated bicarbonate and finally water.[1]

In vivo: So far, no in vivo data has been reported.

Clinical trial: So far, no clinical trial has been conducted.

Reference:
[1] Paul R, Anderson GW.  N,N'-Carbonyldiimidazole, a new peptide forming reagent. J. Am. Chem. Soc. 1960 Sep; 82: 4597-600.

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References on CDI (1,1′-Carbonyldiimidazole)

1,1'-Carbonyldiimidazole (CDI) Mediated Coupling and Cyclization To Generate [1,2,4]Triazolo[4,3-a]pyridines.[Pubmed:26808327]

Org Lett. 2016 Feb 5;18(3):560-3.

An operationally efficient CDI mediated tandem coupling and cyclization reaction to generate [1,2,4]triazolo[4,3-a]pyridines has been reported. The reaction conditions and scope were investigated, and the methodology was demonstrated in batch mode as well as in a continuous process.

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