Morellic acid

CAS# 5304-71-2

Morellic acid

Catalog No. BCN3073----Order now to get a substantial discount!

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Morellic acid: 5mg $322 In Stock
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Quality Control of Morellic acid

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Chemical structure

Morellic acid

3D structure

Chemical Properties of Morellic acid

Cas No. 5304-71-2 SDF Download SDF
PubChem ID 54580250 Appearance Powder
Formula C33H36O8 M.Wt 560.7
Type of Compound Miscellaneous Storage Desiccate at -20°C
Synonyms (-)-Morellic Acid
Solubility Soluble in chloroform and DMSO
Chemical Name (Z)-4-[(1S,2S,17S,19R)-12-hydroxy-8,8,21,21-tetramethyl-5-(3-methylbut-2-enyl)-14,18-dioxo-3,7,20-trioxahexacyclo[15.4.1.02,15.02,19.04,13.06,11]docosa-4,6(11),9,12,15-pentaen-19-yl]-2-methylbut-2-enoic acid
SMILES CC(=CCC1=C2C(=C(C3=C1OC(C=C3)(C)C)O)C(=O)C4=CC5CC6C4(O2)C(C5=O)(OC6(C)C)CC=C(C)C(=O)O)C
Standard InChIKey COVMVPHACFXMAX-OYNOKLRGSA-N
Standard InChI InChI=1S/C33H36O8/c1-16(2)8-9-20-26-19(11-12-30(4,5)39-26)24(34)23-25(35)21-14-18-15-22-31(6,7)41-32(28(18)36,13-10-17(3)29(37)38)33(21,22)40-27(20)23/h8,10-12,14,18,22,34H,9,13,15H2,1-7H3,(H,37,38)/b17-10-/t18-,22+,32+,33-/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Morellic acid

The herbs of Garcinia Morella

Biological Activity of Morellic acid

Description1. Morellic acid has cytotoxic activity. 2. Morellic acid has anti-HIV-1 activity. 3. Morellic acid has antibacterial activity.
TargetsHIV | Antifection

Morellic acid Dilution Calculator

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Morellic acid Molarity Calculator

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Preparing Stock Solutions of Morellic acid

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.7835 mL 8.9174 mL 17.8348 mL 35.6697 mL 44.5871 mL
5 mM 0.3567 mL 1.7835 mL 3.567 mL 7.1339 mL 8.9174 mL
10 mM 0.1783 mL 0.8917 mL 1.7835 mL 3.567 mL 4.4587 mL
50 mM 0.0357 mL 0.1783 mL 0.3567 mL 0.7134 mL 0.8917 mL
100 mM 0.0178 mL 0.0892 mL 0.1783 mL 0.3567 mL 0.4459 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Morellic acid

Validation of an HPLC-MS-MS assay for determination of morellic acid in rat plasma: application to pharmacokinetic studies.[Pubmed:26071609]

J Chromatogr Sci. 2015 Nov-Dec;53(10):1695-700.

A selective and rapid high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS-MS) was developed for the quantification of Morellic acid in rat plasma. HPLC was performed using a Capcell MG C18 (50 x 4.6 mm, i.d., 5 microm) column, and isocratic elution with water-acetonitrile (20:80, v/v) at a flow rate of 0.5 mL/min. Sample preparation of analyte and internal standard (gambogic acid) involved liquid-liquid extraction using ethyl acetate-isopropanol (1:1, v/v) from 50 microL plasma. The precursor --> production transitions for analyte and IS were m/z 559.4 --> 471.3, and m/z 627.3 --> 583.3, respectively, and were monitored on a triple-quadrupole mass spectrometer, operating in negative ion scan mode. The method was validated across the dynamic concentration range of 20-7,500 ng/mL for Morellic acid, with a fast run time of 6.0 min. The analytical method measured concentrations of Morellic acid with accuracy (% bias) of Morellic acid was stable during the battery of stability studies. Finally, the applicability of this assay has been successfully demonstrated in vivo pharmacokinetic studies in Sprague-Dawley rats. This method will therefore be useful for further preclinical and clinical pharmacokinetic studies of Morellic acid.

Description

Morellic acid is isolated from Garcinia Morella with an antiangiogenic activity.

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