Gambogellic acidCAS# 173867-04-4 |
Quality Control & MSDS
3D structure
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| Cas No. | 173867-04-4 | SDF | Download SDF |
| PubChem ID | 134715174 | Appearance | Powder |
| Formula | C38H44O8 | M.Wt | 628.76 |
| Type of Compound | Miscellaneous | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| SMILES | CC(=CCC1=C2C(=C(C3=C1OC45C6CC(C=C4C3=O)C(=O)C5(OC6(C)C)CC=C(C)C(=O)O)O)C7CC(O2)(CCC7C(=C)C)C)C | ||
| Standard InChIKey | NVYMXCXFPJLTOZ-JGULFVLLSA-N | ||
| Standard InChI | InChI=1S/C38H44O8/c1-18(2)9-10-23-31-27(24-17-36(8,44-31)13-12-22(24)19(3)4)30(40)28-29(39)25-15-21-16-26-35(6,7)46-37(33(21)41,14-11-20(5)34(42)43)38(25,26)45-32(23)28/h9,11,15,21-22,24,26,40H,3,10,12-14,16-17H2,1-2,4-8H3,(H,42,43)/b20-11+/t21-,22?,24?,26?,36-,37?,38-/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The herbs of Garcinia hanburyi Hook. f.
| Description | 1. Gambogellic acid has cytotoxic activity, it exhibits inhibitory effect against SMMC-7221cell and A549 cell. |
Gambogellic acid Dilution Calculator
Gambogellic acid Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.5904 mL | 7.9522 mL | 15.9043 mL | 31.8086 mL | 39.7608 mL |
| 5 mM | 0.3181 mL | 1.5904 mL | 3.1809 mL | 6.3617 mL | 7.9522 mL |
| 10 mM | 0.159 mL | 0.7952 mL | 1.5904 mL | 3.1809 mL | 3.9761 mL |
| 50 mM | 0.0318 mL | 0.159 mL | 0.3181 mL | 0.6362 mL | 0.7952 mL |
| 100 mM | 0.0159 mL | 0.0795 mL | 0.159 mL | 0.3181 mL | 0.3976 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Cytotoxic xanthones from Garcinia hanburyi.[Pubmed:8835458]
Phytochemistry. 1996 Feb;41(3):815-20.
Eleven novel cytotoxic xanthones, gambogin, morellin dimethyl acetal, isomoreollin B, moreollic acid, gambogenic acid, gambogenin, isogambogenin, desoxygambogenin, gambogenin dimethyl acetal, Gambogellic acid and hanburin were isolated together with four known xanthones, gambogic acid, isomorellin, morellic acid and desoxymorellin, from the dry latex of Garcinia hanburyi. The structures were elucidated by a detailed spectroscopic analysis.
Two new xanthone epimers from the processed gamboge.[Pubmed:27809607]
Nat Prod Res. 2017 Apr;31(7):817-821.
Two new xanthones, gambogollic acid (1), epigambogollic acid (2), together with three rare compounds, Gambogellic acid (3), epiGambogellic acid (4) and gambogic acid (5), were isolated from the processed gamboge. The new structures were determined by 1D and 2D NMR spectroscopic analysis. And the cytotoxicity of these five compounds was evaluated against human hepatoma carcinoma and human lung adenocarcinoma cell. Two new compounds showed excellent antitumor activity. All five compounds exhibited inhibitory effect against SMMC-7221cell and A549 cell.
Gambogellic acid is an xanthone isolated from the processed gamboge, with antitumor activity.
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