Mitotane (Lsodren)Antineoplastic agents against adrenocortical carcinoma CAS# 53-19-0 |
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| Cas No. | 53-19-0 | SDF | Download SDF |
| PubChem ID | 4211 | Appearance | Powder |
| Formula | C14H10Cl4 | M.Wt | 320.04 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Synonyms | 2,4′-DDD; o,p'-DDD | ||
| Solubility | DMSO : ≥ 100 mg/mL (312.46 mM) H2O : < 0.1 mg/mL (insoluble) *"≥" means soluble, but saturation unknown. | ||
| Chemical Name | 1-chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethyl]benzene | ||
| SMILES | C1=CC=C(C(=C1)C(C2=CC=C(C=C2)Cl)C(Cl)Cl)Cl | ||
| Standard InChIKey | JWBOIMRXGHLCPP-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C14H10Cl4/c15-10-7-5-9(6-8-10)13(14(17)18)11-3-1-2-4-12(11)16/h1-8,13-14H | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Mitotane(2,4′-DDD), an isomer of DDD and derivative of DDT, is an antineoplastic medication used in the treatment of adrenocortical carcinoma.
IC50 value:
Target:
Mitotane alters steroid peripheral metabolism, directly suppresses the adrenal cortex and alters cortisone metabolism leading to hypocortisolism. Side effects as reported by Schteinberg et al. include anorexia and nausea (88%), diarrhea (38%), vomiting (23%), decreased memory and ability to concentrate (50%), rash (23%), gynecomastia (50%), arthralgia (19%), and leukopenia (7%). References: | |||||
Mitotane (Lsodren) Dilution Calculator
Mitotane (Lsodren) Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.1246 mL | 15.623 mL | 31.2461 mL | 62.4922 mL | 78.1152 mL |
| 5 mM | 0.6249 mL | 3.1246 mL | 6.2492 mL | 12.4984 mL | 15.623 mL |
| 10 mM | 0.3125 mL | 1.5623 mL | 3.1246 mL | 6.2492 mL | 7.8115 mL |
| 50 mM | 0.0625 mL | 0.3125 mL | 0.6249 mL | 1.2498 mL | 1.5623 mL |
| 100 mM | 0.0312 mL | 0.1562 mL | 0.3125 mL | 0.6249 mL | 0.7812 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Mitotane, or o,p'-DDD, is a derivative of DDT with antiproliferative properties. A study of the antiproliferative effects of Mitotane demonstrated particular efficacy against adrenocortical carcinoma.
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Mitotane(2,4′-DDD), an isomer of DDD and derivative of DDT, is an antineoplastic medication used in the treatment of adrenocortical carcinoma.
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