Epieuphoscopin BCAS# 126372-45-0 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
| Cas No. | 126372-45-0 | SDF | Download SDF |
| PubChem ID | N/A | Appearance | Powder |
| Formula | C33H42O9 | M.Wt | 582.68 |
| Type of Compound | Diterpenoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Epieuphoscopin B Dilution Calculator
Epieuphoscopin B Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.7162 mL | 8.581 mL | 17.1621 mL | 34.3242 mL | 42.9052 mL |
| 5 mM | 0.3432 mL | 1.7162 mL | 3.4324 mL | 6.8648 mL | 8.581 mL |
| 10 mM | 0.1716 mL | 0.8581 mL | 1.7162 mL | 3.4324 mL | 4.2905 mL |
| 50 mM | 0.0343 mL | 0.1716 mL | 0.3432 mL | 0.6865 mL | 0.8581 mL |
| 100 mM | 0.0172 mL | 0.0858 mL | 0.1716 mL | 0.3432 mL | 0.4291 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Macrocyclic Diterpenoids from the Latex of Euphorbia helioscopia.[Pubmed:26882659]
Nat Prod Commun. 2015 Dec;10(12):2037-9.
One new jatrophane diterpenoid, 7alpha,9beta,15beta-triacetoxy-3beta-benzoyloxy-14beta-hydroxyjatropha-5E,11E-diene (3), together with four known macrocyclic diterpenoids, euphoheliosnoid A (1), Epieuphoscopin B (2), euphohelioscopin A (4) and euphoscopin C (5), were isolated from the stem latex of Euphorbia helioscopia. Their structures were established by spectroscopic analyses. In the anti-inflammatory assay, euphohelioscopin A (4) exhibited moderate inhibitory activity on the release of cytokine TNF-alpha (IC50 = 23.7 +/- 1.7 muM), IL-6 (IC50 = 46.1 +/- 1.1 muM) and chemokine MCP-1 (IC50 = 33.7 +/- 3.8 muM) in lipopolysaccharide (LPS) induced RAW 264.7 macrophages without notable cytotoxicity (IC50 > 80 muM).
Cytotoxic macrocyclic diterpenoids from Euphorbia helioscopia.[Pubmed:19099222]
Arch Pharm Res. 2008 Dec;31(12):1547-51.
A new cytotoxic macrocyclic diterpenoid, euphornin L (1), together with seven known analogues were isolated from the plant Euphorbia helioscopia L. The structure of 1 was elucidated by spectral data and X-ray crystallographic analysis. Euphornin L (1) and euphoscopin F (2) exhibited significant cytotoxicity against HL-60 cell lines with IC(50) values of 2.7 and 9.0 microM, respectively. The 13C-NMR data of euphoscopin F (2), Epieuphoscopin B (3), euphoscopin B (5), and euphoscopin C (6) were also reported for the first time.
Discovery of a new series of jatrophane and lathyrane diterpenes as potent and specific P-glycoprotein modulators.[Pubmed:18452010]
Org Biomol Chem. 2008 May 21;6(10):1756-62.
A new series of diterpenes, the jatrophanes euphoscopin M (1), euphoscopin N (2) and euphornin L (3), and the lathyrane euphohelioscopin C (7) were isolated from plants of Euphorbia helioscopia L., together with four other known analogues, euphoscopin C (4), euphornin (5), Epieuphoscopin B (6) and euphohelioscopin A (8). The new compound stereostructures were elucidated by NMR analysis and computational data. The resulting isolated diterpenes were found to be potent inhibitors of P-glycoprotein (ABCB1), while showing an absence of significant activity against BCRP (ABCG2), despite the high substrate overlapping of these transporters, thus including them in the third-generation class of specific multidrug transporter modulators.
