Flemichin DCAS# 57096-07-8 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 57096-07-8 | SDF | Download SDF |
| PubChem ID | 124344 | Appearance | Powder |
| Formula | C25H26O6 | M.Wt | 422.5 |
| Type of Compound | Flavonoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (8S)-8-(2,4-dihydroxyphenyl)-5-hydroxy-2,2-dimethyl-10-(3-methylbut-2-enyl)-7,8-dihydropyrano[3,2-g]chromen-6-one | ||
| SMILES | CC(=CCC1=C2C(=C(C3=C1OC(CC3=O)C4=C(C=C(C=C4)O)O)O)C=CC(O2)(C)C)C | ||
| Standard InChIKey | DFVFCZXJTRKRPI-FQEVSTJZSA-N | ||
| Standard InChI | InChI=1S/C25H26O6/c1-13(2)5-7-17-23-16(9-10-25(3,4)31-23)22(29)21-19(28)12-20(30-24(17)21)15-8-6-14(26)11-18(15)27/h5-6,8-11,20,26-27,29H,7,12H2,1-4H3/t20-/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Flemichin D Dilution Calculator
Flemichin D Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.3669 mL | 11.8343 mL | 23.6686 mL | 47.3373 mL | 59.1716 mL |
| 5 mM | 0.4734 mL | 2.3669 mL | 4.7337 mL | 9.4675 mL | 11.8343 mL |
| 10 mM | 0.2367 mL | 1.1834 mL | 2.3669 mL | 4.7337 mL | 5.9172 mL |
| 50 mM | 0.0473 mL | 0.2367 mL | 0.4734 mL | 0.9467 mL | 1.1834 mL |
| 100 mM | 0.0237 mL | 0.1183 mL | 0.2367 mL | 0.4734 mL | 0.5917 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Inhibition of tyrosinase activity by polyphenol compounds from Flemingia philippinensis roots.[Pubmed:24412339]
Bioorg Med Chem. 2014 Feb 1;22(3):1115-20.
Flemingia philippinensis is used as a foodstuff or medicinal plant in the tropical regions of China. The methanol (95%) extract of the roots of this plant showed potent tyrosinase inhibition (80% inhibition at 30mug/ml). Activity-guided isolation yielded six polyphenols that inhibited both the monophenolase (IC50=1.01-18.4muM) and diphenolase (IC50=5.22-84.1muM) actions of tyrosinase. Compounds 1-6 emerged to be three new polyphenols and three known flavanones, Flemichin D, lupinifolin and khonklonginol H. The new compounds (1-3) were identified as dihydrochalcones which we named fleminchalcones (A-C), respectively. The most potent inhibitor, dihydrochalcone (3) showed significant inhibitions against both the monophenolase (IC50=1.28muM) and diphenolase (IC50=5.22muM) activities of tyrosinase. Flavanone (4) possessing a resorcinol group also inhibited monophenolase (IC50=1.79muM) and diphenolase (IC50=7.48muM) significantly. In kinetic studies, all isolated compounds behaved as competitive inhibitors. Fleminchalcone A was found to have simple reversible slow-binding inhibition against monophenolase.
Cytotoxic and antimycobacterial prenylated flavonoids from the roots of Eriosema chinense.[Pubmed:19555123]
J Nat Prod. 2009 Jun;72(6):1092-6.
Eight new prenylated flavonoids, khonklonginols A-H (1-8), together with six known compounds including five flavonoids, lupinifolinol (9), dehydrolupinifolinol (10), Flemichin D (11), eriosemaone A (12), and lupinifolin (13), and one lignan, yangambin (14), have been isolated from hexane and dichloromethane extracts of the roots of Eriosema chinense. The structures of 1-8 were elucidated by spectroscopic methods. The compounds were evaluated for cytotoxic activity against the small-cell lung (NCI-H187) and oral epidermal carcinoma (KB) human cell lines as well as for antimycobacterial activity against Mycobacterium tuberculosis H37Ra.
[Studies on the chemical constituents of Flemingia philippinensis].[Pubmed:1887793]
Yao Xue Xue Bao. 1991;26(1):42-8.
Two new prenylated flavonoids, flemiphilippinin C (I) and flemiphilippinin D (II) have been isolated from the root of Flemingia philippinensis (Merr. et Rolfe) Li along with four known compounds. The structure of I and II were elucidated as 7-(.4'-hydroxy-3'-methoxyphenyl)-5-hydroxy-2, 2-dimethyl-10-prenyl-2H,6H-benzo-[1,2-b:5,4-b']dipyran-6-one and 5,7,2',4'-tetrahydroxy-6,8-diprenylisoflavanone, respectively, on the basis of chemical and spectroscopic data. The four known compounds were identified as 5,7,3',4'-tetrahydroxy-6,8-diprenylsilflavone (III), Flemichin D (IV), beta-sitosterol (VI) and lupeol (VII), and a mixture of n C22-C30 aliphatic acid (V). Compounds III and IV showed significant cytotoxic activities against P388 cell cultures.
