Fuziline

CAS# 80665-72-1

Fuziline

Catalog No. BCN2822----Order now to get a substantial discount!

Product Name & Size Price Stock
Fuziline: 5mg $35 In Stock
Fuziline: 10mg Please Inquire In Stock
Fuziline: 20mg Please Inquire Please Inquire
Fuziline: 50mg Please Inquire Please Inquire
Fuziline: 100mg Please Inquire Please Inquire
Fuziline: 200mg Please Inquire Please Inquire
Fuziline: 500mg Please Inquire Please Inquire
Fuziline: 1000mg Please Inquire Please Inquire

Quality Control of Fuziline

Number of papers citing our products

Chemical structure

Fuziline

3D structure

Chemical Properties of Fuziline

Cas No. 80665-72-1 SDF Download SDF
PubChem ID 14163819 Appearance White powder
Formula C24H39NO7 M.Wt 453.58
Type of Compound Alkaloids Storage Desiccate at -20°C
Synonyms 15α-Hydroxyneoline; Senbusine C
Solubility Soluble in methan
Chemical Name 11-ethyl-6,18-dimethoxy-13-(methoxymethyl)-11-azahexacyclo[7.7.2.12,5.01,10.03,8.013,17]nonadecane-4,7,8,16-tetrol
SMILES CCN1CC2(CCC(C34C2C(C(C31)C5(C6C4CC(C6O)C(C5O)OC)O)OC)O)COC
Standard InChIKey FPECZWKKKKZPPP-UHFFFAOYSA-N
Standard InChI InChI=1S/C24H39NO7/c1-5-25-9-22(10-30-2)7-6-13(26)23-12-8-11-16(27)14(12)24(29,21(28)17(11)31-3)15(20(23)25)18(32-4)19(22)23/h11-21,26-29H,5-10H2,1-4H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Fuziline

1 Delphinium sp.

Biological Activity of Fuziline

DescriptionFuziline shows significant insecticidal activity against Nilaparvata legen and Aphis medicagini. Fuziline shows activity against pentobarbital sodiuminduced cardiomyocytes damage by obviously recovering beating rhythm and increasing the cell viability.
TargetsAntifection
In vitro

Alkaloids isolated from the lateral root of Aconitum carmichaelii.[Pubmed: 22907155 ]

Molecules, 2012, 17(8):9939-46.

Two new alkaloids, aconicarmine (1) and aconicaramide (5), were isolated from the EtOH extract of the lateral roots of Aconitum carmichaelii, together with five known compounds: Fuziline (2), neoline (3), N-ethylhokbusine B (4), 5-hydroxymethylpyrrole-2-carbaldehyde (6), and oleracein E (7).
METHODS AND RESULTS:
Their structures were elucidated by physical and NMR analysis. Pyrrole alkaloids were isolated from A. carmichaelii for the first time. In the in vitro assays, compounds 2 and 3 showed activity against pentobarbital sodiuminduced cardiomyocytes damage by obviously recovering beating rhythm and increasing the cell viability, while compounds 5 and 7 showed moderate antibacterial activity.

In vivo

The pharmacological research progress of Fuziline and Neoline[Reference: WebLink]

《Pharmacy and Clinics of Chinese Materia Medica》 2014-03

By analyzing and summarizing pharmacological research literature about Fuziline and Neoline,the pharmacological research of both drugs are found to be mainly concentrated on the cardiovascular system,analgesia,anesthesia,antitumor,insecticidal,and so on.At the same time,Fuziline and Neoline are lack of a comprehensive and systematic pharmacological research.

Development and validation of a UHPLC-qTOF-MS method for quantification of fuziline in rat plasma and its application in a pharmacokinetic study.[Pubmed: 24782408]

Biomed Chromatogr. 2014 Dec;28(12):1707-13.


METHODS AND RESULTS:
A specific and sensitive UHPLC-qTOF-MS method was developed and validated for quantification of Fuziline in rat plasma after oral administration of three dosages. The analyte was separated on an Acquity UPLC BEH C18 column with a total running time of 3 min using a mobile phase of 0.1% formic acid aqueous solution and methanol (80:20, v/v) at a flow-rate of 0.25 mL/min. The calibration curves for Fuziline showed good linearity in the concentrations ranging from 1 to 200 ng/mL with correlation coefficients >0.997. The precision, accuracy, recovery and stability were deemed acceptable. The method was applied to a pharmacokinetics study of Fuziline in rats. The mean half-life was 5.93, 6.13 and 5.12 h for 1, 2 and 4 mg/kg oral administration of Fuziline, respectively. The peak concentration and area under the concentration-time curve increased linearly with the doses.
CONCLUSIONS:
The sum of these results indicated that, in the range of the doses examined, the pharmacokinetics of Fuziline in rat was based on first-order kinetics.

Fuziline Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

Fuziline Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of Fuziline

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.2047 mL 11.0234 mL 22.0468 mL 44.0937 mL 55.1171 mL
5 mM 0.4409 mL 2.2047 mL 4.4094 mL 8.8187 mL 11.0234 mL
10 mM 0.2205 mL 1.1023 mL 2.2047 mL 4.4094 mL 5.5117 mL
50 mM 0.0441 mL 0.2205 mL 0.4409 mL 0.8819 mL 1.1023 mL
100 mM 0.022 mL 0.1102 mL 0.2205 mL 0.4409 mL 0.5512 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University
Featured Products
New Products
 

References on Fuziline

Development and validation of a UHPLC-qTOF-MS method for quantification of fuziline in rat plasma and its application in a pharmacokinetic study.[Pubmed:24782408]

Biomed Chromatogr. 2014 Dec;28(12):1707-13.

A specific and sensitive UHPLC-qTOF-MS method was developed and validated for quantification of Fuziline in rat plasma after oral administration of three dosages. The analyte was separated on an Acquity UPLC BEH C18 column with a total running time of 3 min using a mobile phase of 0.1% formic acid aqueous solution and methanol (80:20, v/v) at a flow-rate of 0.25 mL/min. The calibration curves for Fuziline showed good linearity in the concentrations ranging from 1 to 200 ng/mL with correlation coefficients >0.997. The precision, accuracy, recovery and stability were deemed acceptable. The method was applied to a pharmacokinetics study of Fuziline in rats. The mean half-life was 5.93, 6.13 and 5.12 h for 1, 2 and 4 mg/kg oral administration of Fuziline, respectively. The peak concentration and area under the concentration-time curve increased linearly with the doses. The sum of these results indicated that, in the range of the doses examined, the pharmacokinetics of Fuziline in rat was based on first-order kinetics.

Alkaloids isolated from the lateral root of Aconitum carmichaelii.[Pubmed:22907155]

Molecules. 2012 Aug 20;17(8):9939-46.

Two new alkaloids, aconicarmine (1) and aconicaramide (5), were isolated from the EtOH extract of the lateral roots of Aconitum carmichaelii, together with five known compounds: Fuziline (2), neoline (3), N-ethylhokbusine B (4), 5-hydroxymethylpyrrole-2-carbaldehyde (6), and oleracein E (7). Their structures were elucidated by physical and NMR analysis. Pyrrole alkaloids were isolated from A. carmichaelii for the first time. In the in vitro assays, compounds 2 and 3 showed activity against pentobarbital sodiuminduced cardiomyocytes damage by obviously recovering beating rhythm and increasing the cell viability, while compounds 5 and 7 showed moderate antibacterial activity.

Description

Fuziline is a alkaloid isolated from the lateral roots of Aconitum carmichaelii.

Keywords:

Fuziline,80665-72-1,15α-Hydroxyneoline; Senbusine C,Natural Products, buy Fuziline , Fuziline supplier , purchase Fuziline , Fuziline cost , Fuziline manufacturer , order Fuziline , high purity Fuziline

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: